4 . At 1:43 a.m. October 5, 2022, Stanford chemist Carolyn R. Bertozzi was awakened by a phone call from a Nobel committee representative who told her, “You have 50 minutes to collect yourself and wait until your life changes.” Instructed not to share the announcement outside of her tightest inner circle, the first person Bertozzi called was her father, a retired physics professor from MIT. “He’s 91 and, of course, he was just overjoyed,” said Bertozzi.

Carolyn Bertozzi, born October 10, 1966, Boston, was awarded the Nobel Prize in chemistry for her development of bioorthogonal reactions, which allow scientists to explore cells and track biological processes without disturbing the normal chemistry of the cell. She shares the $10 million Swedish kronor (about $1 million USD) prize equally with Morten Meldal, professor at University of Copenhagen and K. Barry Sharpless, professor at Scripps Research “for the development of click chemistry and bioorthogonal chemistry.”

Carolyn received a bachelor’s degree in chemistry from Harvard University in 1988 and a doctorate in the same subject from the University of California, Berkeley in 1993. She was a postdoctoral fellow at the University of California, San Francisco, from 1993 to 1995. She became an assistant professor at Berkeley in 1996 and a full professor of chemistry and molecular and cell biology in 2002. She also held an appointment as a professor of molecular and cellular pharmacology from 2000 to 2002 at the University of California, San Francisco. In 2015 she became a professor of chemistry at Stanford University.

“I could not be more delighted that Carolyn Bertozzi has won the Nobel Prize in chemistry,” said Stanford President Marc Tessier-Lavigne. “In pioneering the field of bioorthogonal chemistry, Carolyn invented a new way of studying biomolecular processes, one that has helped scientists around the world gain a deeper understanding of chemical reactions in living systems. Her work has had remarkable real-world impact, providing new diagnostic and therapeutic approaches to treat disease. Carolyn is so deserving of this honor, and all of us at Stanford are too proud to call her one of our own.”

Carolyn’s bioorthogonal reactions have been used to study how cells build proteins and other molecules, to develop new cancer medicines, and to produce new materials for energy storage, among many other applications.

5 . Albert Einstein was born in Ulm, Germany on 14 March, 1879.     1     Einstein was so smart that at age 16 he wrote his first paper. However, Einstein did badly at school.     2     He ended up at college in Switzerland. His grades meant it was difficult to get a job after college, but a friend found him work finally.

Albert had a great year in 1905, publishing (发表) four scientific papers!     3     One of the things he researched was that energy and mass (质量) are different forms of the same thing. This was explained by his famous equation E=mc². In 1909 Albert was finally made a professor at the University of Zurich. He continued improving his work, and in 1915 he published his theory of general relativity (广义相对论) .

In 1919, one of Albert’s theories was proved, making him the most famous scientist alive!     4    His work changed the way we think about time and space, and also helped with developments like the television.

    5     And in 1933, Albert decided to stay in the USA forever. He became an American in 1940. Sadly, Einstein’s work with atoms (原子) led to the invention of the atomic bomb. Albert spent the rest of his life taking part in activities for world peace. He died in 1955.

7 . An extremely rare manuscript(手稿) signed by English naturalist Charles Darwin is expected to fetch up to $790,00at a Sotheby’s auction next month. The document contains a passage from the famous 1859 work On the Origin of Species, in which Darwin put forth his theory of evolution.

The document was once thought to be a deserted page from an earlier manuscript of the work. But experts now understand it was written in 1865 and sent to the editor of the Autographic Mirror who had requested a signed writing sample from Darwin.

“While some of Darwin's notes and manuscript pages have survived over the last hundred or more years, he was known to keep revising his publications, often throwing away pages from working drafts as waste paper, making them extremely rare,” Sotheby's said in a statement.

On the Origin of Species was voted the most influential academic book of all time in a public poll held during Academic Book Week in 2015.The book offers Darwin's revolutionary idea that species evolve over generations in the process of natural selection.

Darwin backed up his theory with evidence collected during his 1831—1836 voyage on the H.M S. Beagle, during which he observed and collected specimens (标本) from a number of species. On the Galapagos Islands off the coast of Ecuador, Darwin noted that the finches(鸣雀)on the island were similar to finches on the mainland; however, the availability of different foods in each area had led to differences in beak shapes.

The manuscript will be placed on display at Sotheby's in New York between Nov.30 and Dec 8, and online bids will be accepted between Now.25 and Dec.8.The auction house estimates that the document will fetch between $600,000 and $790,000.

The auction, which is titled Age of Wonder, will also include a first edition of On the Origin of Species and a copy of scientific paper by Darwin and another naturalist.

Sharon Brown    1    (win) a Women in Innovation award in 2021 for her work in developing a blood test that can help to identify cancer quicker and more accurately. The award was given by an organisation    2    (call) Innovate UK for International Women’s Day celebrations. Sharon is one of 38 women from the UK to have received the award. The award aims to support brilliant women to    3    (full) achieve their visions and change the world in future.