1 . ________________ the fact that she was wearing a seat belt, she was thrown sharply forward. (用适当的词填空)

2 . ________ the public argument over genome editing, its possibilities have created much excitement through the entire medical community and beyond. (用适当的词填空)

3 . _________the heavy rain, they still went out for a walk. (用适当的词填空)

4 . ________ the figures of 200 injured in the earthquake at large, only 5 students suffered slight injuries. （用适当的词填空）