1 . The first wave of a new class of anti-aging drugs have begun human testing. These drugs won't let you live longer but aim to treat specific illnesses by slowing a fundamental process of aging.
The drugs are called senolytics—they work by removing certain cells that accumulate as we age. Known as “senescent” cells, they can create low-level inflammation (炎症) that prevents normal systems of living cells repair and creates a poisonous environment for neighboring cells.
In June, San Francisco - based Unity Biotechnology reported initial results in patients with mild to severe osteoarthritis (关节炎) of the knee. Results from a larger clinical trial are expected in the second half of this year. The company is also developing similar drugs to treat age-related diseases of the eyes and lungs, among other conditions.
Senolytics are now in human tests, along with a number of other promising approaches targeting the biological processes that lie at the root of aging and various diseases.
A company called Alkahest injects patients with components found in young people's blood and says it hopes to stop conscious and functional decline in patients suffering from mild to moderate Alzheimer's disease. The company also has drugs for Parkinson's and dementia in human testing.
And in December, researchers at Drexel University College of Medicine even tried to see if a cream including the immune-suppressing drug could slow aging in human skin.
The tests reflect researchers' expanding efforts to learn if the many diseases associated with getting older- such as heart diseases, arthritis, cancer, and dementia- can be dealt with to delay their outbreak.
1. Why do the researchers develop the drugs?| A．To rid inflammation. | B．To lengthen people's life. |
| C．To treat age-related diseases. | D．To remove cancer cells. |
| A．Repairing. | B．Cycling. | C．Aging. | D．Dividing. |
| A．By listing data. | B．By providing details. |
| C．By making comparisons. | D．By analyzing causes. |
| A．A diary. | B．A guidebook. | C．A novel. | D．A magazine. |
2 . During the COVID-19 pandemic, Julia began her second year as a first grade teacher in an online classroom. One September afternoon, she received a call from and Cynthia, who was having technical difficulties with her granddaughter's tools for online learning.
Julia immediately knew something was wrong with Cynthia. The two women had spoken many times before, but Julia had never heard she sounded like this. Her words were so jumbled that Julia could barely understand her. Julia called her headmaster, Charlie, who convinced her that he would call and check on Cynthia himself.
Just like Julia, Charlie could barely understand Cynthia. He suspected she might be having a stroke (中风) — he recognized the signs from when his own father had suffered one. Charlie immediately became concerned that Cynthia's two grandchildren, ages six and eight, were probably home alone with her and scared. Charlie asked his office manager to send an ambulance to the grandmother's home.
The quick response from Julia and Charlie saved Cynthia's life. She arrived at the hospital in time to get treatment before long-term damage occurred. Thanks to an extended stay in the hospital, she has regained most of the movement throughout her body except for one hand and a region of her mouth.
“I'm proud of the people I work with, that they responded so quickly and that it did make a difference to Cynthia,” says Julia. “I am so pleased to be part of such a caring community.” But the school's crisis response is only one piece of the community's extraordinary efforts to help Cynthia and her granddaughters. Another family with young children took in the two girls.
Virtual learning has been a challenge across the country, but it's fair to say that it has helped the community grow closer. Many teachers there gave their personal phone numbers to students and families in case they needed extra help. In this case, the exchange was literally life-altering.
1. Cynthia called Julia in order to .| A．complain about the poor contents of online learning |
| B．consult about her granddaughter's academic performance |
| C．seek some help for lack of certain technical knowledge |
| D．volunteer her services as a teacher in an online classroom |
| A．brief |
| B．unclear |
| C．gentle |
| D．impolite |
| A．By recalling his own previous sufferings from the disease. |
| B．By using his professional knowledge to form the judgment. |
| C．By combining Julia's call with the granddaughters' description. |
| D．By identifying the symptoms that a stroke patient may have. |
| A．It has caused much inconvenience to parents. |
| B．It will bring about unavoidable leak of privacy. |
| C．It has provided more benefits than challenges. |
| D．It needs technical guidance to be highly effective. |
3 . The use of AI (artificial intelligence) is becoming more common in many branches of industry and online shopping. Traditional lines of work, such as goods transport and driving, are developing in a similar direction although mainly out of public view. Scientists at the University of Göttingen have now investigated how efficient (高效的) the use of AI can be in the commercial management of trucks.
“Digital applications—as well as machine leaning, a kind of AI—are increasingly applied to operations and courses in the transport area,” explains Professor Matthias Klumpp from the Faculty of Economics. “The question in the commercial area, however, is whether or not this contributes to achieving goals.”
To answer this question, the researchers compared the work efficiency of truck drivers with their main use of AI applications. Looking at trade delivery by truck, they studied three groups: the first drove completely following human decision-making models; the second used a combination of human and machine; and the third depended completely on fully automated decisions.
The researchers found that an intelligent combination of human work and decision-making abilities with AI applications promises the highest transport and driving efficiency. “On average, the second group achieved the most efficient transport trips, with the fewest interventions (干预) and off-course from the best path.” one researcher said, “Clearly, neither a completely human decision-making structure nor a fully automated driving system can promise to meet current goods transport requirements.” The scientists therefore summarized that despite the progress of AI in the field of transportation by truck, human experience and decision-making abilities will still be necessary in the longer term. However, the challenge is that a wide range of training and qualification (资格) needs will come along by working with Al applications, especially for simple goods transport activities.
1. What does Matthias Klumpp focus on?| A．The efficiency of AI. |
| B．The advantages of AI. |
| C．The problems caused by AI. |
| D．The wide applications of AI. |
| A．By providing examples. |
| B．By making comparisons. |
| C．By using different trucks. |
| D．By listing three experiments. |
| A．Al is better at making decisions. |
| B．A balance is needed between human and AI. |
| C．Human will soon be replaced by AI in driving. |
| D．Al applications meet the current requirements. |
| A．The future of transport. |
| B．Artificial intelligence as a co-driver. |
| C．Artificial intelligence-a better choice in driving. |
| D．The strengths of artificial intelligence in transport. |
4 . At 88, I remain a competitive runner. The finish line of my life is drawing close, and I hope to reach it having given the best of myself along the way. I’ve been training my body to meet the demands of this final stretch. But, I wonder, should I have asked more of my mind?
If I didn’t exercise, I would release the hungry beasts that seek their elderly prey on couches, but not in the gym. The more I sweated, the more likely it was my doctor would continue to say, “Keep doing what you’re doing, and I’ll see you next year.” My mind, on the other hand, seems less willing to give in to discipline. I have tried Internet “brain games”, solving algebraic problems flashing past and changing the route of virtual trains to avoid crashes. But these never approach my determination to remain physically fit as I move deeper into old age.
Though I have many friends in their 70s, 80s and 90s, I’ve been far too slow to realize that how we respond to aging is a choice made in the mind, not in the gym. Some of my healthiest friends carry themselves as victims abused by time. Other friends, many, whose aching knees and hips are the least of their physical problems, find comfort in their ability to accept old age as just another stage of life to deal with. I would use the world “heroic” to describe the way they cope with aging.
One such friend recently called from a hospital to tell me a sudden brain disease had made him legally blind. He interrupted me as I began telling him how terribly sorry I was: “Bob, it could have been worse. I could have become dead instead of blind.”
In spite of all the time I spend lifting weights and exercising, I realized I lack the strength to have said those words. It suddenly struck me that I’ve paid a price for being a “gym rat”. If there is one characteristic common to friends who are aging with a graceful acceptance of life’s attacks, it is contentment. Aging had to be more than what I saw in a mirror.
But rather than undertaking a fundamental change in the way I face aging. I felt the place to begin would be to start small. A recent lunch provided a perfect example.
I’ve always found it extremely difficult to concentrate when I’m in a noisy setting. At this lunch with a friend in an outdoor restaurant, a landscaper began blowing leaves from underneath the bushes surrounding our table. Typically, after such a noisy interruption, I would have snapped, “let’s wait until he’s finished!. ”, then fallen silent. When the roar(吼叫)eventually faded, my roar would have drained(消耗)the conversation of any warmth. It troubled me that even a passing distraction(分心)could so easily take me from enjoying lunch with a good friend to a place that gave me no pleasure at all. I wanted this meal to be different.
My years in gyms had taught me to shake off pains and other distractions, never permitting them to stop my workout or run. I decided to treat the noise this way. I continued talking with my friend, challenging myself to hear the noise, but to hold it at a distance. The discipline was so familiar to me in the gym—this time applied to my mind— proved equally effective in the restaurant. It was as though I had taken my brain to a mental fitness center.
Learning to ignore a leaf blower’s roar hardly equips me to find contentment during my passage into ever-deeper old age. But I left the lunch feeling I had at least taken a small first step in changing behavior that stood in the way of that contentment.
Could I employ that same discipline to accept with dignity the unavoidable decline awaiting me like the finish line? Hoping that contentment will guide me as I make my way along the path yet to be travelled.
1. The author’s question in Paragraph 1 implies that ________.| A．he feels unsatisfied with the result of the brain games. |
| B．he has never believed the necessity of mind training. |
| C．He has realized he should mentally prepare for aging. |
| D．he feels regret for not sharpening his thinking skills |
| A．He takes physical illnesses as they come. |
| B．He fears that his illness will become worse. |
| C．He needs to find a way through those hardships. |
| D．He sees life as a series of disappointments. |
| A．he had made small changes to adapt to aging. |
| B．the restaurant was not an ideal place for eating |
| C．distractions were not uncommon in everything life. |
| D．his roar had spoiled the friendly conversation. |
| A．Benefits of Regular Exercise |
| B．Old Age Hate and Blessing |
| C．Never Too Old to Learn |
| D．The Secret to Aging Well |
5 . After beating bone cancer, Hayley Arceneaux thinks rocketing into orbit on SpaceX’s first private flight should be no problem at all. St. Jude Children’s Research Hospital announced the 29-year-old doctor’s assistant will rocket into space later this year.
Arceneaux, a former patient at St. Jude, will become the youngest American in space, beating NASA record-holder Sally Ride by over two years. She will travel with businessman Jared Isaacman, who is using the spaceflight he bought to raise money for charity. Two other yet-to-be-chosen space flyers will join them. Arceneaux will be the first person to launch with a prosthesis an artificial device that replaces a missing or injured part of the body. When she was 10, Arceneaux had an operation at St. Jude to replace her knee and a piece of metal was put in her left leg. She still limps and has occasional leg pain.
“My battle with cancer really prepared me for space travel,” she recently told The Associated Press. “It made me tough, and then also I think it really taught me to expect the unexpected and go along for the ride.” Arceneaux wants to show her young patients and other cancer survivors that “the sky is not even the limit anymore.” “It’s going to mean so much to these kids to see a survivor in space.” she said.
Isaacman announced his space flight on February 1, promising to raise $200 million for St. Jude. As the flight’s self-appointed commander, he offered one of the four seats aboard SpaceX’s Dragon spacecraft to St. Jude. The hospital chose Arceneaux from among its many workers who had once been patients. The idea was that one of them could represent the new generation, noted Rick Shadyac, president of St. Jude’s financing organization.
Arceneaux was at home in Memphis, Tennessee, when she got a surprising call in January. She was asked if she would represent St. Jude in space. As a lifelong space fan who loves adventures, Arceneaux has traveled widely and loves roller coasters. Isaacman, who flies fighter airplanes for fun, considers her a perfect fit. The launch is planned for this fall at NASA’s Kennedy Space Center, with the spacecraft orbiting Earth for two to four days.
1. Which statement is true about Hayley Arceneaux?| A．She works where she used to be a patient. |
| B．She is an adventure hater. |
| C．She is the youngest American in space. |
| D．She is the first woman space flyer. |
a. She received a surprising call. b. She was diagnosed with a serious disease.
c. She was chosen to rocket into space. d. She was operated on at St.Jude.
| A．a c d b | B．b c d a | C．b d a c | D．c a b d |
| A．To carry out medical research. |
| B．To explore space. |
| C．To expect the unexpected. |
| D．To collect money. |
| A．Generous and strong. |
| B．Caring and optimistic. |
| C．Brave and honest. |
| D．Patient and representative. |
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7 . It’s common knowledge that the woman in Leonardo da Vinci’s most famous painting seems to look back at viewers, following them with her eyes no matter where they are in the room. But this common knowledge turns out wrong.
A new study finds that the woman in the painting is actually looking out at an angle of 15.4° off to the viewer’s right — well outside the range that people normally believe when they think someone is looking right at them. In other words, said the study author, Horstmann, “She’s not looking at you.”
This is ironic (讽刺), because the entire phenomenon of a person’s gaze (凝视) in a photograph or painting seeming to follow the viewer is called the “Mona Lisa effect”, which is absolutely real. If a person is illustrated or photographed looking straight ahead, even people viewing the portrait from an angle will feel they are being looked at. As long as the angle of the person’s gaze is no more than about 5 degrees off to either side, the Mona Lisa effect occurs.
Horstmann and his co-author were studying this effect for its application in the creation of artificial-intelligence avatars (虚拟头像) when Horstmann took a long look at the “Mona Lisa” and realized she wasn’t looking at him.
To make sure it wasn’t just him, the researchers gathered 24 people to view images of the “Mona Lisa” on a computer screen. They set a ruler between the viewer and the screen and asked the participants to note which number on the ruler intersected (相交) Mona Lisa’s gaze. To calculate the angle of Mona Lisa’s gaze as she looked at the viewer, they moved the ruler farther from or closer to the screen during the study. Consistently, the researchers found, participants judged that the woman in the “Mona Lisa” portrait was not looking straight at them, but slightly off to their right.
So why do people repeat the belief that her eyes seem to follow the viewer? Horstmann isn’t sure. It’s possible, he said, that people have the desire to be looked at, so they think the woman is looking straight at them. Or maybe the people who first coined the term “Mona Lisa effect” just thought it was a cool name.
1. It is generally believed that the woman in the painting “Mona Lisa” ________.| A．attracts the viewers to look back |
| B．seems mysterious because of her eyes |
| C．fixes her eyes on the back of the viewers |
| D．looks at observers wherever they stand |
| A．The Mona Lisa effect does not really exist. |
| B．The mystery of the woman’s smile in the painting. |
| C．The angle of the gaze in Mona Lisa effect. |
| D．Mona Lisa effect does not occur with Mona Lisa. |
| A．confirm Horstmann’s belief |
| B．create artificial-intelligence avatars |
| C．calculate the angle of Mona Lisa’s gaze |
| D．show how the Mona Lisa effect can be applied |
| A．Horstmann thinks it cool to coin the term “Mona Lisa effect”. |
| B．The Mona Lisa effect contributes to the creation of artificial intelligence. |
| C．Feeling being gazed at by Mona Lisa may be caused by the desire for attention. |
| D．The position of the ruler in the experiment will influence the viewers’ judgement. |
8 . China was a latecomer to space exploration, and in the movies, it has been a latecomer to science fiction. That has probably changed.
The country’s first blockbuster (大片) set in space, The Wandering Earth, opened in February amid high expectations that it would represent the beginning of a new era in Chinese filmmaking. Shown in 3D, The Wandering Earth takes place in a distant future in which the sun is about to expand into a red giant and devour (吞食) the Earth. The approaching danger forces the world’s engineers to work out a plan to move the planet to a new solar system. Things go very badly when Earth has to pass Jupiter, setting off a desperate fight to save humanity from being totally destroyed.
The Wandering Earth is adapted from a short novel by Liu Cixin, the writer who has led a renaissance in science fiction in China. His works are great epics (史诗) and deeply researched. Translating them into movies would challenge any filmmaker, as the director of The Wandering Earth, Guo Fan, admitted.
Guo noted that Chinese Studios had been cautious about investing the resources required to make convincing science-fiction. The budget for The Wandering Earth reportedly reached nearly $50 million— modest by Hollywood standards but still significant in China. “I really hope this movie will not lose money at least,” said Guo before the movie’s release. The popularity of Liu’s novels could help. So could the fact that China has reached a milestone in space: the landing of a probe (航天探测器) on the far side of the moon in January. Although decades behind Russia and the United States, China has now put astronauts in orbit and has ambitious plans to join---or even lead---a new age of space exploration.
Unlike some typical Hollywood movies, The Wandering Earth does not feature a world-saving hero. The fight to save Earth is fought instead by a group. A vision of international cooperation to cope with the threats facing the Earth is a theme that runs deeply through Liu’s fiction.
1. What message does the success of the movie The Wandering Earth convey?| A．It lives up to the audience’s high expectations. |
| B．It marks a new height of the Chinese filmmaking industry. |
| C．It displays China’s ambition to lead space exploration. |
| D．It sets new and higher standards for Chinese movies. |
| A．giant investment of Chinese studios | B．the high reputation of the film director |
| C．China’s advances in space exploration | D．the deep research and world-saving theme |
| A．A New Era for Space Exploration Begins |
| B．A Film Based on Liu Cixin’s Novel Enjoys Great Popularity |
| C．China’s First Space-Themed Film Features Cooperation |
| D．China’s Film Industry Eventually Joins the Space Race |
9 . Nothing succeeds like success, as every parent of a straight-A student knows, but trying to stress academic excellence by telling your child, “You’re so smart!” may be counterproductive. Why? According to a 2017 study, children who think their intelligence is fixed are less likely to pay attention to and bounce back（重新振作）from mistakes than children who think intelligence can grow and change.
In the study, researchers looked at 123 children. The team assessed the children to determine whether they had a “growth mindset”(believing that you can work harder to get smarter), or a “fixed mindset” (believing that your intelligence is unable to change). They then asked the children to complete a fast-paced computer accuracy task while their brain activity was recorded. During the recording, researchers noted that brain activity stopped within a half-second after making a mistake, as children became aware of their mistake and paid closer attention to what went wrong. The larger the brain response was, the more the child focused on the mistake. Based on the data, they concluded that children with a “growth mindset” were much more likely to have a larger brain response after making a mistake. While children with a “fixed mindset” were able to “bounce back”, only if they gave their full attention to the mistake.
For parents, the lessons are clear. Don’t pay your children compliments that suggest that intelligence is fixed. If your child hands you an A+ score, don’t say, “You’re so smart!” Instead, say, “Wow, that studying really paid off!” or “You clearly mastered this material-way to go!” Note the effort, not the intelligence.
Besides, many parent shy away from addressing a child’s mistakes, telling them “It’s OK. ”You’ll get it next time. ” without offering them the chances to figure out what goes wrong. Instead, it’s better to reassure your children that mistakes happen, and work to figure out where and how they make the mistake.
1. Which of the following best explains “counterproductive” underlined in paragraph 1?| A．Opposite | B．Competitive |
| C．Successful | D．Unknown |
| A．They made fewer mistakes. | B．They tried to avoid mistakes |
| C．They had smaller brain response | D．They focused more on the mistake. |
| A．You are so careless |
| B．Paying compliments to children |
| C．You’ll get it the next time |
| D．Let’s find out how you made it. |
| A．Overstressing the intelligence. |
| B．Pay compliment to children. |
| C．Addressing children’s mistakes. |
| D．Offering chances to find mistakes. |
10 . Soft robots, which can move around the ocean without harming sea life, are ideal for underwater exploration. However, they are not so welcome in robot market because they are extremely slow and have a hard time operating through the water. But that may change soon thanks to a self-driven soft robot created by researchers at the University of California, San Diego.
The recently-developed robot, which resembles a paper lantern, was primarily built using soft materials. Its flexible ribs are attached to a circular plate at both ends. An adjustable nozzle (喷嘴) fitted on one side helps draw in and jet (射出) water each time the robot shrinks. The resulting jets of water enable it to swim forward, similar to a squid (乌贼). A plate holds a waterproof component that can house a camera to record data, which is of great value to further development of the robot. It also has its own power source, allowing it to float autonomously for long periods of time.
“Essentially, we recreated all the key features that squids use for high-speed swimming. This is the first robot that can achieve these jets of water by changing its body shape, which improves swimming efficiency,” said Professor Michael T. Though the squid robot has not been tested in open waters, it successfully swam around coral and fish in a large tank in the UC San Diego Birch Aquarium. What’s more, the robot clocked an impressive speed of 18 to 32 centimeters per second, or about half a mile per hour. Though nowhere close to real squids, it is faster than most other soft robots.
“After we were able to improve the design of the robot so that it would swim in a tank in the lab, it was especially exciting to see that the robot was able to successfully swim in a large tank among coral and fish, showing its possibility for real-world applications,” said Caleb Christianson, who led the study as part of his Ph. D paper.
1. Why were the previous soft robots seldom used?| A．Their application places are limited. |
| B．They do great damage to sea life. |
| C．They are very difficult to control. |
| D．Their advertising effect is hot good. |
| A．Their body material. | B．Their general speed. |
| C．Their power source. | D．Their swimming pattern. |
| A．It is the first robot that can transform. |
| B．It will function well in open waters. |
| C．It has every feature that a squid has. |
| D．It can defeat most other soft robots in speed. |
| A．Positive. | B．Critical. | C．Uncaring. | D．Doubtful. |
