1 . With the drugs that she created, Getrade Elion achieved her life’s mission: to relieving human suffering. Beyond the individual drugs she discovered, she pioneered a now, more scientific approach to drug development that forever changed medical research.
When she was 15, Elion’s grandfather died from cancer painfully. The experience decided her career path. At age 19, with a degree in chemistry, she looked for work. She took jobs as a secretary, a chemistry teacher, and an unpaid worker in a lab. Finally, in 1944, Elion found the job of her dreams, assisting George Hitchings at Burroughs Wellcome, a drug company.
Hitchings and Elion gave up the traditional trial-and-error approach to drug development, in favor of a scientific approach. Starting from the understanding that all cells require nucleic acid (核酸) to reproduce, they reasoned that rapidly growing bacteria (细菌) require even more to keep the pace of growth. Find a way to disrupt (扰乱) their life cycle, and you find a way to stop disease.
Elion’s first major discovery was a substance that disrupts the formation of leukaemia cells. But the effect failed to last long. Elion determined to find a way to make the effects of her drug last longer.
Elion’s final major breakthrough was in the development of the drug acyclovir. Scientists doubted that drugs could be invented to fight viruses: any substance that would kill a virus would be poisonous to the body. However, through tireless efforts, the drug Elion’s team developed could be used to fight many diseases. Elion’s name appears on 45 patents for life-saving and life-changing drugs.
Though her individual discoveries were significant, when Elion received the Nobel Prize in Physiology or Medicine in 1988, it wasn’t for one particular drug — it was for a new, more reasonable approach to drug development. As a result, although she died in 1999 at the age of 81, Gertrude Elion is still saving lives.
1. What inspired Elion to go into medical research?A.Her grandfather’s death. | B.Her teaching experience. |
C.A drug company’s influence. | D.George Hitching’s encouragement. |
A.Finding a poisonous substance to kill viruses. |
B.Quickening the speed of growth of all cells. |
C.Preventing the formation of bacteria. |
D.Removing tissues attacked by bacteria. |
A.It should be put into use immediately. |
B.It might be harmful to human bodies. |
C.It could only have short-term effects. |
D.It could be used to fight many diseases |
A.She pioneered a new way of developing drugs. |
B.She discovered a life-saving drug. |
C.She obtained 45 patents. |
D.She adopted a trial-and-error approach in medical research |
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