1 . In a study published in Nature Machine Intelligence, researchers at Ohio State University show how artificial intelligence（AI）can follow clinical trials to identify drugs for repurposing, a solution that can help advance innovative treatments.
Repurposing drugs is legal and not unusual. When doctors prescribe(开处方)drugs that have been approved by the Food and Drug Administration(FDA)for purposes different from what is printed on the labels, the drugs are being used “off-label” Just because a drug is FDA-approved for a specific type of disease does not prevent it from having possible benefits for other purposes.
For example, Metformin, a drug that is FDA-approved for treating type 2 diabetes, is also used to treat PCOS(a disease of women), and other diseases. Trazodone, an anti-depressant with FDA-approval to treat depression, is also prescribed by doctors to help treat patients with sleep issues.
The Ohio State University research team created an AI deep learning model for predicting treatment probability with patient data including the treatment, outcomes, and potential confounders(干扰因素).
Confounders are related to the exposure and outcome. For example, a connection is identified between music festivals and increases in skin rashes(红疹). Music festivals do not directly cause skin rashes. In this case, one possible confounding factor between the two may be outdoor heat, as music festivals tend to run outdoors when the temperature is high, and heat is a known cause for rashes. When working with real-world data, confounders could number in the thousands. AI deep learning is well-suited to find patterns in the complexity of potentially thousands of confounders.
The researcher team used confounders including population data and co-prescribed drugs. With this proof-of-concept, now clinicians have a powerful AI tool to rapidly discover new treatments by repurposing existing medications.
1. What do we know about a drug used off-label?| A．It is sold without a label. |
| B．It is available at a low price. |
| C．Its uses extend beyond the original ones. |
| D．Its clinical trials are rejected by doctors. |
| A．are used off-label |
| B．treat rare diseases |
| C．result in sleep issues |
| D．are medical breakthroughs |
| A．They are possible treatments. |
| B．They are environmental factors. |
| C．They can be easily recognized in real-world data. |
| D．They should be taken into serious consideration. |
| A．AI examines benefits of existing drugs. |
| B．AI identifies off-label uses for drugs. |
| C．AI finds new drugs for common diseases. |
| D．AI proves the power of drug research. |
2 . If you have ever had a cat, or have watched one of the many funny cat videos online, you’ll know that cats have a mind of their own. A lot of the things they do are hard to understand---they like to climb up tall furniture, fit themselves in small spaces and attack small objects for no reason at all.
Now scientists have managed to figure out what exactly is going on in the brains of our little friends. According to Tony Buffington, a professor at Ohio State University in the US, cats’ strange behavior largely comes from their way of life back in the wild. “Cats today still have many of the same instincts(本能)that allowed them to live in the wild for millions of years.” he said in a TED Talk. “To them, our homes are their jungles.”
In the wild, cats are hunters. Their bodies and great balancing abilities allow them to climb to high spots to better look at the environment. Even though they don’t have to hunt any more in human houses, they still keep the old habit of viewing the living room from, for example, the top of the refrigerator.
Cats’ hunting instinct is also what makes them attack small things like keys and USB drives. In the wild, they hunt whatever they can get, and most of the animals they kill are small.
However, cats can also be prey. This explains why they like to stay in small spaces like drawers or washing machines---they are hiding, or they think they are hiding, from more dangerous animals. This is also why cats prefer a clean box: a smelly one could easily show enemies where they are.
Knowing how cats’ minds work is not only useful for better understanding them. It may also help cats’ owners to better meet cats’ needs. For example, owners could try to make climbing easier for cats by moving their furniture around. They could also use “food puzzles” to make eating feel more like hunting instead of just giving food to the cats.
1. According to Tony Buffington, ________.| A．cats’ strange behavior is hard for people to understand |
| B．cats are more used to living in the wild than in humans’ homes |
| C．cats behave strangely mainly because of some instincts in the wild |
| D．cats’ instincts are as helpful to them today as they were millions of year ago |
| A．Cats like to climb up high because they want to hide from dangerous animals. |
| B．Cats attack keys and USB drives because they have a habit of hunting small animals. |
| C．Cats enjoy staying in small spaces because they usually live in small caves in the wild. |
| D．Cats’ preference for a clean box probably has something to do with their hunting instincts. |
| A．an animal that is too lazy |
| B．an animal that likes hiding games |
| C．an animal that keeps itself clean |
| D．an animal that is hunted |
| A．explore the reasons behind cats’ strange behavior |
| B．describe cats’ past wild experience to readers |
| C．tell cat owners how to make life easier for cats |
| D．compare cats’ behavior in human homes with that in the wild |
3 . A facial expression results from one or more motions of the muscles of the face. These movements convey the emotional nonverbal communication. They are a primary means of conveying social information among humans, but also occur in most other mammals and some other animal species.
In the business world, much emphasis is placed on your first words, but it isn’t all about what you say. You only have seconds to make a first impression that can make or break a relationship in business. Since the face is the first thing we notice about a person, it’s vital to use your face to make that important connection.
Researchers have shown that 55 percent of non-verbal communication is facial. People generally try to mask negative expressions such as disappointment, fear or envy, but these feelings are often reflected in their eyes, or the downward turn of the mouth.
Genuine expressions of anger and surprise can be quite brief, lasting for only a few seconds. If an expression remains longer, it may be a sign of insincerity (不真诚). In general, a genuine expression matches the beginnings of a feeling, so watch for expressions that come after the words.
The research conducted last year by a team from Glasgow University, suggested that people from different cultures read facial expressions differently. Not only can that mean confusion in everyday life, but it can lead to confusion when conducting business.
The study found that East Asian participants tended to focus on the eyes of the other person, while Western subjects took in the whole face, including the eyes and the mouth. The work, which was published in Current Biology journal challenged the idea that facial expressions are universally understood. In the study, East Asians were more likely than Westerners to read the expression for "fear" as "surprise", and "disgust "as "anger".
1. According to the text, in the business world ________.| A．people focus more on your words than your facial expressions |
| B．people usually have no time to make a first impression |
| C．the relationship between people is very sensitive |
| D．facial expressions are very important in creating business connections |
| A．genuine expressions usually last for a short time |
| B．the expressions that come after the words are not genuine |
| C．55 percent of people use facial expressions as non-verbal communication |
| D．negative expressions are very easy to hide |
| A．Easterners are likely to examine the eyes more attentively |
| B．Easterners read facial expressions more correctly |
| C．Westerners pay equal attention to the eyes and the mouth |
| D．Westerners think facial expressions are universally understood |
| A．The result of the study makes it difficult to do business. |
| B．Only humans can convey through facial expressions. |
| C．Negative emotions are easily reflected in the eyes. |
| D．Current Biology financially supports the study. |
| A．facial expressions in business |
| B．how to convey negative expressions |
| C．facial expressions and social skills |
| D．how to increase cross-cultural understanding |
4 . In an ideal world, we might be able to live free from discrimination. But not this one, in which we are constantly dividing everything into “us" and “them".
This is especially true during times of fear, like now, when the novel coronavirus is spreading across China and the world. It's a time when “us" means safe and clean while “them" means infectious and risky. Or at least we'd like to believe so.
But this is actually a misbelief, which has been fueled and promoted by fear, and sadly, the media. When the outbreak first started, the term “Wuhan virus" was used in some news, creating hostility （敌意）toward people from Wuhan and Hubei as a whole. There were reports of hotels refusing to accept guests from Hubei and some hospitals denied their entry even when they needed treatment for other medical problems.
Elsewhere in the world, German magazine Der Spiegel labeled the virus on its cover as “Made in China". Australia's Herald Sun, meanwhile, printed, “China Kids Stay Home" on its front page, implying that all kids from China are carriers of the virus. It's also reported that Chinese people overseas have faced harassment （骚扰）and even violence.
This kind of misbelief is exactly why and when the World Health Organization （WHO） was trying to come up with a name for the disease, it had to be careful. “We had to find a name that did not refer to a geographical （地理的）location, an animal, an individual or group of people," said Tedros Adhanom Ghebreyesus, Director-General of the WHO, on Feb 11. And COVID-19 was the final decision.
World leaders and institutes are also sharing sensible voices. "There is no place in our country for discrimination driven by fear or misinformation," Canadian Prime Minister Justin Trudeau said at a Lunar New Year celebration in Toronto on Feb 2. Cornell University also sent an email to students and faculty, saying, “We need to remember to care for one another and not make assumptions about others' symptoms or any characteristics of identity."
It's understandable that during times like this, we want to go to extreme lengths to make sure we're safe. But fear is never part of the cure. Only love and independent thinking takes you further.
1. What is the main purpose of Paragraphs 3 and 4?| A．To explain what has brought about misbelief. |
| B．To show how some news media misled the public. |
| C．To compare how different countries responded to COVID --- 19. |
| D．To present what Chinese people overseas suffer from COVID --- 19. |
| A．show positive attitudes in face of COVID ---19 |
| B．explain why it is important to prevent discrimination |
| C．describe different opinions of the influence of the virus |
| D．introduce measures taken by foreign countries to fight COVID---19 |
| A．Neutral. | B．Supportive. | C．Opposed. | D．Unconcerned. |
| A．We should always be willing to care for others. |
| B．Fear and discrimination are as contagious as a virus. |
| C．We shouldn't let misinformation influence our own judgment. |
| D．The media should give people confidence during times of fear. |
5 . A comparison of nesting data recorded in the early 1900s with similar data today for more than 200 species of California birds shows that over all they are breeding(繁殖)5 to 12 days earlier than they did 75 to 100 years ago.
Earlier studies found that many but not all birds in California’s mountains are moving north or to higher altitude to find cooler temperatures in the face of global warming.
The shift to earlier breeding that we detected allows birds to nest at similar temperatures as they did a century ago, and helps explain why half the bird species in the mountainous areas of California did not need to shift upward in altitude in response to climate warming over the past century, said Steven Beissinger, a UC Berkeley professor of environmental sciences.
Early spring arrivals have long been noted by the public and reported by scientists, but the assumption has been that the birds are tracking resources, primarily food: with warming temperatures, plants produce leaves and seeds earlier, and insects appear earlier.
The new study spotlights another major reason: by nesting a week earlier, birds produce eggs and young at a temperature about 1 degree Celsius lower than if they nested at the normal time in the same place. This exactly counterbalances the approximately 1 degree Celsius increase in global temperatures over the past century.
“By nesting a week or 10 days earlier, birds are avoiding some of the negative effects of climate warming,”Beissinger said.” the good news is that there may be more flexibility for species to respond to climate change than we thought, and not all species may need to move farther north or to higher altitudes, “he added. “But we don't know yet whether staying in place and shifting schedules earlier is a permanent solution, or only provides temporary relief from the 2 degree Celsius rise in temperatures forecast to occur.”
Birds may find, for example, that the window of good temperatures for breeding becomes shorter, which may limit the opportunity to re-nest if they fail the first time. Larger species that have a longer nesting period might not have an enough time to complete their nests before it starts to become too warm, he said.
1. To fight against the global warming, earlier studies found that _______.| A．some birds tried to find cooler places |
| B．some birds failed to nest more than ever |
| C．some birds began to produce eggs earlier |
| D．some birds woke up earlier to catch insects |
| A．Early birds catch insects and get tender leaves |
| B．Global warming is responsible for earlier springs |
| C．Birds are smart in adapting to the climate changes |
| D．Birds are likely to have difficulty in breeding ways |
| A．Adds to |
| B．Reduces to |
| C．Makes up for |
| D．Goes along with |
| A．Birds’ moving north and global warming. |
| B．Early breeding of birds and climate changes. |
| C．Changes of birds’ life and early spring arrivals |
| D．Birds' reaction and early appearance of foods. |
6 . If you're one of the millions of those who use escalators each year, you are probably deeply familiar with the vertical grooves（竖凹槽）that cover each stair. Few of us have stopped to consider why they exist, though. In fact, it's one of the everyday things we take for granted.
But it is a little complicating when you think about it. Sure, the deep, grey lines make an escalator's metal stairs more appealing to the eye. But regular stairs don't have grooves like these; why do escalators need them? Is it because of the movement?
It turns out those grooves serve a more functional purpose. And, yes, it does have to do with the movement, as well as with general cleanliness! Anyone who has ridden an escalator knows that the steps everlastingly circulate from the top to the bottom. You've surely noticed the ridged yellow lip at the top of the escalator. But here's what you may not have noticed: As an escalator's steps flatten, this ridge—also called the comb plate—sweeps away any trash or litter that might have fallen on the stairs. Those grooves lock the step and comb plate together, which makes it harder for any dangerous materials to slide underneath the lip. This prevents foreign objects from getting stuck in that gap, potentially causing the escalator to stop, or worse, break down completely.
That's not the only reason why the grooves were created, though. They are also a good place for water to pool together, protecting you from a bad fall on the slick surface.
So the next time you step on an escalator, take a moment to appreciate those metal grooves. They exist to make sure you get to your office meeting on time.
1. What are the first two paragraphs trying to say?| A．Millions of people use escalators every year. |
| B．Few people think much about the grooves. |
| C．Escalators are complicated machines. |
| D．Grooves make the stairs look better. |
| A．clean off dangerous objects. |
| B． keep the stairs in movement. |
| C．flatten the steps. |
| D．lock the steps. |
| A．Smooth. | B．Sticky. |
| C．Steep. | D．Slippery. |
| A．The importance of escalators. |
| B．The reasons for grooves on stairs. |
| C．The look of grooves in escalators. |
| D．The safe ways of riding escalators. |
by Helaia Fox
If you're looking for a moving story that explores themes of mental illness, grief (悲痛), and love, pick up a copy of How It Feels to Float and follow Biz as she comes of age. This moving novel will stay with you long after you finish reading it.
Two Can Keep a Secretby Karen M. MeManus
Put on your crime-solving cap and get swept away in this thriller about a girl, a boy, and a string of unsolved murders. As threats and clues pile up, you’ll be burning the midnight oil trying to finish the book before dawn.
Forest of a Thousand Lanternsby Julie C. Dao
The first book in the Rise of the Empress series takes the bones of a traditional fairy tale — a poor girl fated for power, an evil queen determined to stop her, love for someone who doesn't love back and magic — and gives them a richly imagined East Asian setting.
Duneby Frank Herbert
If the Star Wars movies have made you fall in love with the space opera, eventually you're going to read Frank Herbert's most famous creation. The story of centuries-old political plotting — about warring factions (派系) battling over control of the extremely valuable planet Arrakis — is a classic and remains a wonderful introduction to the larger, more complex world of science fiction just beyond the Star Wars trilogies.
1. What is How It Feels to Float mainly about?| A．The murder of a teenage girl. |
| B．A girl's space adventures. |
| C．Challenges of growing up. |
| D．A poor girl with special powers. |
| A．A fairy tale. | B．A science-fiction story. |
| C．A love story. | D．A detective story. |
| A．How It Feels to Float | B．Two Can Keep a Secret |
| C．Forest of a thousand Lanterns | D．Dune |
8 . It’s normal for teens to want to stay connected with friends and social circle, but what about that happening in the middle of the night? The Journal of Youth Studies recently published new research showing that one in five teens from 12 to 15 regularly wake to spend all night on social media (社会媒体). Not surprisingly, the research also showed that these social night owls were three times more likely than others to feel tired at school and that girls were more likely than boys to be called to office.
The blue light produced by cell phones and computers makes the brain to stay awake, so it's easy to see why a teen might be up all night. A study in Psychological Science showed the same brain reaction: when teens saw large numbers of “likes” on their posts, they stayed awake with excitement as if they had eaten chocolates or won money. Besides not catching up on sleep and interrupting their sleep cycle, teens may never fully enter deep sleep that may be responsible for brain development and learning.
Considering about 72 percent of children from 6 to 17 sleep with some electronic media in their bedrooms, parents need to set rules sooner rather than later.
“Providing access (使用机会) to social media is a favor that children can earn and also lose,” Janie Feldman, an expert who treats sleep disorders (紊乱), reminds parents, “The bad effect is clear. So teens and parents should discuss and agree on its use, timing and access. When teenagers agree to the rules, it’s easier for parents to control how much time they use the phones or computers.”
1. What does the underlined part “night owls” in paragraph 1 refer to?| A．Girls often called to office. |
| B．Teens who stay up late on social media. |
| C．Teens who are busy with their homework at night. |
| D．Boys regularly waking in the middle of the night. |
| A．They are too excited to go to sleep. |
| B．They fall asleep easily and happily. |
| C．They are too excited to go to school. |
| D．They decide to make more good friends. |
| A．Making rules about media access together with their children. |
| B．Getting their children to do homework through computers. |
| C．Encouraging their children to stay connected with online friends. |
| D．Stopping their children from using cell phones. |
| A．Deep sleep makes a big difference to brain development. |
| B．Kids are trying to win back the trust of their parents. |
| C．Social media may have a bad effect on all kinds of people. |
| D．Social media may cause teens’ sleep disorders. |
9 . What kind of amusing activities will you participate in during your life? Will you be spending your free time doing safe sports with little danger or will you always be one of the first people to try the next popular extreme activity? Scientists have been interested in finding out why some people seem to prefer dangerous activities.
Although there are exceptions, researchers have found that in most cases men are less cautious than women. Men often try to impress women by proving that they are courageous and fearless, and they are more likely to take risks when women are watching them or when they are competing against other men.
Research also shows that as people get older they usually behave more responsibly and avoid taking unnecessary risks. In addition, when people are in stable relationships, they seem to be less attracted to daring activities.
Some people seem to be more daring than others, but there are many different types of risks and some people take one type of risk, but not another Psychologists have identified a number of categories of risk. These include financial risks, risks related to health and safety, amusing risks and social risks. Psychologists discover that some people will take risks in one area, but not in another. Just if a person enjoys bungee (蹦极) jumping, it doesn't mean he or she will take chances when investing (投资) money or that he will tell a joke to a group of strangers.
Interestingly, research shows that women take more social risks than men. They are more likely to make career changes as they get older and to express unpopular opinions in business meetings.
Yet, at the end of the day, the likelihood of particular people taking a risk depends on their personalities. In general, optimistic people are more likely to take risks because they focus on the possible positive outcomes of their actions. On the other hand, those with opposite personality are much more likely to avoid taking a chance.
1. What have researchers discovered about women?| A．They are always changing jobs. | B．They are good at doing business. |
| C．They are more willing to take risks. | D．They are more conservative than men. |
| A．To attract women to watch them. | B．To have favorable effects on women. |
| C．To announce risks are too dangerous. | D．To show their strength to the competitor. |
| A．The potential consequences. | B．Their characters. |
| C．Their problems of finance. | D．The focuses of their work. |
| A．People's sense of taking risks. | B．Risks at people's different ages. |
| C．Different types of people's risks. | D．Risks between men and women. |
10 . SYDNEY —Australian scientists have designed a system which uses microwaves to break down plastic into an environmentally friendly by-product.
Head of Electrical Engineering at Australia’s James Cook University, Prof. Mohan Jacob revealed on Thursday that by using microwaves, plastic waste can be converted into biochar(生物炭), charcoal that can be used as a soil conditioner.
“We are developing a processing room, which could process many kinds of plastic materials, up to 5 kilograms of waste,” Jacob said. “It will be a typical example system for the development of biochars from different types of plastics under various conditions.” Jacob explained that microwave energy is used to heat the plastic waste above 600 degrees centigrade within the custom-made room, where it ends up as a biochar, which can then be used to improve the properties of soil.
Currently underway is step one of the project, testing the room, after which, step two will involve improving the energy efficiency of the system and maximizing the yield of by-products. If all goes to plan, step three will be to construct a medium scale waste processing system which is customizable and can be installed remotely.
Jacob said that with the average person using 130 kg of plastic every year, there is an urgent need for developing better ways of processing it.
“Perhaps contrary to popular opinion, plastic is an indispensable material in modern life. It is cheap, competent, lightweight, and has many benefits like maintaining food quality and safety and preventing waste,” he said.
However, “abandoned plastics endanger our marine wildlife, and have begun to enter the food chain. There is an urgent need for developing technologies to recover plastic waste.”
1. How does the system function?| A．Microwaves are used to produce plastic. |
| B．Plastic waste is heated in the microwaves. |
| C．Plastic waste is cut into pieces and buried into the soil. |
| D．Microwaves change plastic waste into biochar by heating. |
| A．Plastic consumption now is acceptable. |
| B．Plastic should be abandoned in our life. |
| C．The system of processing plastic has come into use. |
| D．Finding better ways to deal with plastic waste is urgent. |
| A．Make up for a loss in time. |
| B．Find or regain lost possession. |
| C．Extract or recycle an energy source for reuse. |
| D．Return to a normal state of health, mind or strength. |
| A．3 steps of processing plastic waste. |
| B．A way of producing plastic products easily. |
| C．A new system of breaking down plastic waste. |
| D．A program designed for plastic use in the daily life. |
