1 . A man with advanced Parkinson’s disease (帕金森氏症) is now able to walk almost normally again thanks to electrodes implanted (电极植入) in his spinal cord (脊椎), researchers said on Monday. The medical first was achieved by Swiss researchers who had previously pioneered similar breakthroughs to help disabled people walk again.
“This could be a game-changing technology to help bring back movement in people with advanced Parkinson’s,” said David Dexter, research director at Parkinson’s UK.
Marc Gauthier, the 62-year-old patient who lives in France, has suffered from the brain disorder for about 30 years. Like more than 90 percent of people with advanced Parkinson’s, Mar c has had great difficulty walking. What are known as “freezing” experiences — during which patients are unable to move for a limited time, putting them at risk of falling — are particularly awful, Marc told AFP.
Much remains unknown about Parkinson’s disease, making treatment difficult. But the disease can seriously affect the lives of patients, sometimes keeping them to bed or a wheelchair. So when the opportunity came to go through an operation in Switzerland, Marc gladly accepted the chance.
“Now I can do whatever I want,” Marc says. “I can go for a walk and go out shopping by myself.” He adds that he can now walk much more easily — he is even planning a trip to Brazil — but it still requires concentration, particularly when climbing upstairs.
The Swiss team, led by surgeon Jocelyne Bloch and neuroscientist Gregoire Courtine , implanted a complex system of electrodes called a “neuroprosthesis (神经假体)” at important points along Marc’s spinal cord. The neuroprosthesis was first tested on animals, and then implanted in Marc, who has used it for roughly eight hours a day over nearly two years.
The Swiss team has expanded their experiment to a group of six Parkinson’s patients, aiming to know how it could help others, given the disease affects people in different ways. However, treatment using the implant could be quite expensive, potentially limiting how many patients would have access.
1. What is David Dexter’s attitude to the Swiss breakthrough?| A．Unconcerned. | B．Doubtful. | C．Positive. | D．Unclear. |
| A．Volunteer as a tour guide in Brazil. | B．Run to his heart’s content. |
| C．Go to the supermarket alone. | D．Make a phone call while climbing the stairs. |
| A．It was first tested on Marc Gauthier. | B．It is hardly affordable for ordinary people. |
| C．It has been performed on many patients. | D．It was done by researchers in the UK. |
| A．A Spinal Implant Allows a Parkinson’s Patient to Walk Again |
| B．Parkinson’s Patients Have to Deal With Difficulties in Life |
| C．Swiss Experts Have Created a Drug to Treat Parkinson’s |
| D．New Technology Prevents People From Developing Parkinson’s |
2 . Shenzhen in Guangdong province has become the first city in China to allow specialist nurses to prescribe (开药方) selected drugs and order tests, in a move that is expected to increase efficiencies in the healthcare system and reduce the patient-load burden on physicians.
Under a new rule in October that took effect in January, eligible nurses will be permitted to order examinations, treatments considering their expert skills and knowledge of specialist nursing or community healthcare. Their prescriptions must be based on existing diagnoses (诊断) made by physicians.
To become a nursing specialist, applicants should have a bachelor’s degree in nursing, five years of working experience, obtained an advanced nursing qualification and have attended a months-long specialist training program and passed a final test.
“Medical institutions must review inappropriate prescriptions given by nurses,” said the regulation. “Nursing specialists who are found to have given three or more improper prescriptions will have their prescribing power stopped for three to six months and will have to undergo retraining before regaining the authorization,” it added.
“Considering the difference in professional positioning, medical education background and work experience between physicians and nurses, it is necessary to fully analyze the necessity and practicability of the nurses’ prescriptive authority,” the commission said.
Zhou Wensi has a bachelor’s degree in nursing and is now a specialist nurse in periodontitis (牙周炎) , or gum disease, at Shenzhen Stomatology Hospital in the city’s Pingshan district.
“Our hospital has not begun allowing us to prescribe. If the rule goes into effect in the future, we’ll likely be able to directly prescribe mouthwash, anti-inflammatory drugs and painkillers to patients,” she said.
However, she also noted that most patients visiting the hospital are in need of treatment delivered by doctors with assistance from nurses like her, so the new regulation is not expected to have a major impact.
1. Why does Shenzhen give permission for specialist nurses’ special rights?| A．To improve the overall ability of the specialist nurses. |
| B．To speed up the development of the healthcare system. |
| C．To enhance the work efficiency and lighten doctors’ load. |
| D．To respond to the demands of doctors, nurses and patients. |
| A．well-recognized | B．Qualified | C．flexible | D．hard-working |
| A．A specialist nurse should follow the rules strictly. |
| B．No institutions take charge of the prescriptions . |
| C．Not all specialist nurses can prescribe drugs freely . |
| D．A specialist nurse always has the prescribing power. |
| A．Doubtful. | B．Indifferent. | C．Neutral. | D．Hopeful. |
Cholera used to be one of the most
Tuyouyou was chosen as a researcher of a team of scientists
4 . Healthy human skin is covered with bacteria (细菌) that are quick to settle in an open wound. To prevent these organisms from spreading through the body, which can permanently injure or kill a person, the infected wound may need to be cleaned and treated with antibiotics. Medical professionals typically identify infections by unwrapping and observing a wound or by swabbing (用拭子擦拭) it and conducting a laboratory test. But removing a wound dressing can slow down the healing process. Plus, observations are subjective, while swab tests take time and require that a patient be physically present.
To address these issues, some research teams are developing devices that sit under bandages and continuously monitor indirect signs of infection, such as changes in wound temperature or acidity. And scientists at the National University of Singapore have now created an even more direct infection sensor.
This sensor can detect an enzyme (酶) called DNase. The enzyme acts as a reliable infection indicator because disease-causing bacteria produce it in large amounts inside wounds, whereas bacteria on healthy skin do not—so testing for the substance reduces the chance of a false positive result. Furthermore, DNase builds up before other infection signs appear. The new alert system, nicknamed the“wireless infection detection on wounds” (WINDOW) sensor, was detailed in Science Advances.
WINDOWs enzyme-sensing parts rely on a material called DNAgel. There searchers developed a particular kind of DNAgel that remains stable in watery environments, such as the human body, but begins to break down in the presence of DNase. They connected this gel (凝胶) to a chip that senses when the gel responds by sending a signal to a smartphone.
Thus far, the team has exposed the DNAgel to wound swabs from 18 people’s wounds to see how much the material degraded in the presence of the bacteria. There searchers also used the device on six living lab mice whose wounds were exposed to the same bacterial species, and it successfully detected infections.
1. What is the first paragraph mainly about?| A．The harm of common wounds. |
| B．The treatment of infected wounds. |
| C．The intervention on wound healing. |
| D．The dilemma of infection observation. |
| A．By comparing wound acidity. |
| B．By detecting the DNase enzyme. |
| C．By measuring the bacteria amount. |
| D．By observing changes in wound color. |
| A．It will cut down the length of infection-treating. |
| B．It could reduce the cost of infection observation. |
| C．It can monitor wounds continuously and remotely. |
| D．It might help conduct laboratory tests on wounds. |
| A．Innovations in Wound Infection Detection |
| B．Removing the Dangers of Open Wounds |
| C．Recognizing the Role of DNase in Healing |
| D．Challenges in Wound Care and Treatment |
Traditional Chinese Medicine (TCM) originated in ancient China. It
Acupuncture was one of the first TCM
In 1997. acupuncture was
Today, TCM is primarily used as an alternative for people
6 . Desperately ill and seeking a miracle, David Bennett Sr. took the last bet on Jan. 7. when be became the first human to be successfully transplanted with the heart of a pig. “It creates the beat; it creates the pressure; it is his heart,” declared Bartley Griffith, director of the surgical team that performed the operation at the University of Maryland Medical Center.
Bennett, 57, held on through 60 tomorrows, far longer than any previous patient who’d received a heart from another species. His remarkable run offered new hope that such procedures, known as xenotransplantation (异种移植), could help relieve the shortage of replacement organs, saving thousands of lives each year.
The earliest attempts at xenotransplantation of organs, involving kidneys from rabbits, goats, and other animals, occurred in the early 20th century, decades before the first successful human-to-human transplants. Rejection, which occurs when the recipient’s body system recognizes the donor organ as a foreign object and attacks it, followed within hours or days. Results improved after some special drugs arrived in the 1960s, but most recipients still died after a few weeks. The record for a heart xenotransplant was set in 1983, when an infant named Baby Fae survived for 20 days with an organ from a baboon (狒狒).
In recent years, however, advances in gene editing have opened a new possibility: re-edit some genes in animals to provide user-friendly spare parts. Pigs could be ideal for this purpose, because they’re easy to raise and reach adult human size in months. Some biotech companies. including Revivicor, are investing heavily in the field. The donor pig was offered by Revivicor from a line of animals in which 10 genes had been re-edited to improve the heart’s condition. Beyond that, the pig was raised in isolation and tested regularly for viruses that could infect humans or damage the organ itself.
This medical breakthrough provided an alternative for the 20% of patients on the heart transplant waiting list who die while waiting or become too sick to be a good candidate.
1. What does the underlined word “run” in paragraph 2 refer to?| A．Donating his heart to a patient. |
| B．Performing the heart operation. |
| C．Living for 60 days after the operation. |
| D．Receiving a new heart from a pig. |
| A．Its history. | B．Its procedure. | C．Its consequence. | D．Its significance. |
| A．Their growth rate and health condition. |
| B．Their life pattern and resistance to viruses. |
| C．Their easiness of keeping and rapid growth. |
| D．Their investment value and natural qualities. |
| A．It introduced new medications to prevent organ rejection. |
| B．It proved the potential for using organs from various animals. |
| C．It guaranteed a sufficient supply of donor pigs for transplants. |
| D．It offered a prospect of replacement organs through gene editing. |
7 . Professors at the University of California San Diego have developed microrobots, which can be a potential treatment for life-threatening cases of bacterial pneumonia, a serious disease affecting lungs and making breathing difficult. In mice, the microrobots safely removed pneumonia-causing bacteria in the lungs and resulted in 100% survival while untreated mice all died within three days after infection.
The microrobots are made of algae (藻类) cells whose surfaces are covered with substances that are filled with antibiotics (抗生素). The algae provides movement, which allows the microrobots to swim around and make antibiotics go directly to more bacteria in the lungs, helping absorb bacteria and clear them of infected cells. This give the microrobots the ability to reduce bacterial infection, which in turn makes them more effective at fighting lung infection.
The work is a joint effort by engineering professors Joseph and Zhang Liangfang. Together, they have pioneered the development of tiny drug-delivering robots that can be safely used in live animals to treat bacterial infections in the stomach and blood. Treating bacterial lung infection is the latest in their line of work.
“In the traditional treatment, sometimes only a very small number of antibiotics will get into the lungs. That’s why many current antibiotic treatments for pneumonia don’t work as well as needed,” said Victor Nizet, a co-worker of Joseph and Zhang “Based on these mouse data, we see that the microrobots could potentially improve the use of antibiotics to kill bacteria and save more patients’ lives.”
The work is still at the proof-of-concept stage. The team plans to do more basic research to understand exactly how the microrobots interact with the immune system (免疫系统). Next steps also include studies to confirm the effectiveness of the microrobot treatment before testing it in larger animals and eventually, in humans. “We’re pushing the boundary further in the field of targeted drug delivery,” said Zhang.
1. How do microrobots work?| A．By doing targeted drug delivery. |
| B．By interacting with antibiotic-filled matter. |
| C．By producing algae cells in lungs. |
| D．By separating harmful cells from healthy ones. |
| A．Doubtful. | B．Subjective. | C．Cautious. | D．Favorable. |
| A．They’ll inspire a new line of research. |
| B．They’ll help strengthen the immune system. |
| C．They’ll have a wider range of application. |
| D．They’ll be a further proof of their concept. |
| A．A scientific invention treating deadly cancers. |
| B．Tiny swimming robots helping treat pneumonia. |
| C．A major breakthrough made in antibiotic research. |
| D．Microrobots employed in the engineering field. |
8 . Annissa Jobb, with a walking stick, went to the office of Riam Shammaa, a pain specialist in Toronto, in 2017. Jobb’s back pain first appeared about a decade earlier due to an undiagnosed herniated disc, which had pressed a nerve. As the pain worsened, Jobb clenched her teeth and tried to keep going. Now she was desperate for help. “I had a drawer full of pain medication. None of it was working.” said Jobb.
Historically, the treatment of such back pain has been less than ideal, sometimes causing patients to become addicted to painkillers or to undergo major surgery, which is suitable for only about 1 in 20 patients. Hunting for a solution beyond these limited options, Dr. Shammaa turned to stem cells—the building-block cells found in various tissues in adult bodies—which can generate a set of different cells. Specifically, he’d been studying bone marrow(骨髓)stem cells, and he invited Jobb to participate in a study with 23 other patients. He hoped that injecting(注射)the stem cells, known as MSCs, into the patient’s herniated disc would multiply and heal the damaged tissue.
The procedure took three and a half hours. It began with the collection of Jobb’s bone marrow—the most painful step—which was immediately distilled(蒸馏)and concentrated into bone marrow mixture, or BMAC, then injected into the discs. Guided by a special type of X-ray, Dr. Shammaa inserted a needle through Jobb’s spine to place the BMAC into the discs. Jobb remained awake for the entire procedure in order to alert Dr. Shammaa if he touched a nerve. Afterward, Jobb recovered in bed for two weeks and then, slowly, began to walk.
A month later she stepped swiftly into the clinic, a moment Dr. Shammaa recalled with delight. “While Jobb had previously described her pain as ‘beyond ten’, she says that it’s now a two.”
1. What is the main idea of the first paragraph?| A．Annissa Jobb’s back pain experiences |
| B．The desperate situation of Annissa Jobb |
| C．The treatment of Annis Jobb’s illness |
| D．The cause for Annissa Jobb’s visit to a pain specialist |
| A．To introduce the process of the previous treatment |
| B．To explain the necessity of Dr. Shammaa’s research |
| C．To show the development of the treatment of back pain |
| D．To provide the supporting evidence for Dr. Shammaa’s research |
| A．They can function in any part of human bodies |
| B．They are able to help cells reproduce and recover |
| C．They will be injected into the tissues nearby herniated disc |
| D．They will be concentrated before collecting patients’s bone marrow |
| A．Jobb has a poor comment on her treatment. |
| B．Jobb has only two pain spots after the treatment. |
| C．Jobb’s back pain has been dramatically relieved. |
| D．Jobb’s back pain is evaluated more precisely than before. |
1. What advice was the woman given?
| A．Getting tested as soon as possible. |
| B．Going to the doctors. |
| C．Staying at home. |
| A．She has a fever. | B．She has a cough. | C．She has a headache. |
| A．On foot. | B．By bike. | C．By car. |
| A．A box. | B．Some food. | C．Some medicine. |
10 . DNA testing is one of modern medicine’s most significant breakthroughs. Today, anyone can receive personalized information about their genes (基因) and ancestry with just a little saliva (唾液). Now, a Seattle-based company is working to bring equally deep analysis to the trillions of proteins within our bodies.
Nautilus Biotechnology, a company founded in 2016 by Seattle’s Sujal Patel and the San Francisco Bay Area’s Parag Mallick, is developing a device to identify and count 95% of the different types of proteins in a biological sample.
Human cells can contain roughly 20,000 different types of proteins, with crucial functions ranging from digestion to disease protection. Each cell has a varying amount of each protein. The company wants to measure the key machinery (机制) inside cells with a level of detail that has never been done before. Existing tools, it says. can only measure up to 8% of the different types of proteins in blood samples.
So why count proteins at all? Research shows healthy cells and diseased cells have differing amounts and forms of each protein. For example, cancer cells may have more of Protein A than Protein B. Knowing that might help in two ways: First, doctors could look for higher Protein A levels to detect cancer early. Second, researchers could better design drugs to target Protein A.
Nautilus says such protein measurements, which are unique to every person and change throughout people’s lives, will not only help doctors identify more specific forms of disease but also help pharmaceutical (制药) companies find more precise drugs with fewer side effects.
While other companies also are building new protein analysis machines, experts and prospective customers have expressed excitement over Nautilus’s approach. Mallick, chief scientist of Nautilus and the brain behind its technology, is confident: “It’s not every day when you get…to work on something. That’s the opportunity to change all of biology.”
1. What is the Seattle-based company doing?| A．Trying to count the amounts of blood cells. |
| B．Examining DNA for personalized information. |
| C．Developing a device to analyze people’s proteins. |
| D．Revealing more about our ancestry with DNA testing. |
| A．Precise drugs are guaranteed. | B．Cell analysis techniques develop fast. |
| C．Proteins are much easier to be analyzed. | D．Protein amounts and forms vary from cell to cell. |
| A．Disease monitoring and machine design | B．Disease detection and drug development. |
| C．Disease prevention and targeted treatment. | D．Disease treatment and side effect prevention. |
| A．Combining DNA Testing with Protein Analysis | B．Setting a New Example of Medical Solution |
| C．Creating Opportunities for Changing Biology | D．Analyzing Proteins for New Medical Breakthrough |
