1 . Drugs that could save tens of thousands of lives in Britain should be prescribed (开药) to three times as many patients as at present, medical experts recommended after a study showed these drugs have great effects on heart disease and stroke (中风).

British research has shown that statins, a class of drug that lowers cholesterol (胆固醇), can prevent a third of all cases of heart disease or stroke in patients at highest risk. If statins were given to 10 million high-risk patients, they could save at least 50,000 lives a year worldwide. In Britain, where heart disease is the leading cause of death, statins could save up to 10,000 lives a year.

Studies have found that safety issues surrounding statins were so tiny that they were significant. The risk of muscle problems was only about one in ten thousand. Fears that statins could increase deaths from other diseases, such as cancer, were assuaged by the study. At present, only people with high cholesterol are prescribed statins, but the eight-year study found that anyone at risk of heart disease or stroke could benefit. Statins are now given to fewer than one in twenty people aged over 40, mostly men with heart disease or high cholesterol. Under the recommendation, this would increase to one in eight.

A total of 20,000 volunteers aged 40 to 80 took part in the study, which looked at the effects of statins on patients for whom the benefits were uncertain. The guidelines previously said that female patients aged over 65 would not benefit from the drug, but the five years of monitoring all types of patients at high risk of heart attacks and stroke showed that everyone benefited as much from statins. The new recommendations will be easy to put into practice because statins are readily available and the patients who benefit from them most are already known to doctors.

5 . This is Your Dream Dance

With growing evidence that dancing helps boost brain health and manage symptoms of neurocognitive (神经认知的) and movement disorders, accessible dance programmes and movement therapists are helping improve the lives of millions.     1    .

There’s actually a lot more happening inside the brain when trying to follow even the simplest choreography (舞蹈编排). “In dance class, we have to learn patterns, and remember sequences,” says David Leventhal, a programme director. The effect extends beyond the dance class to the real world.     2    .

In addition to the physical and neurological benefits, dance can also help people living with disease make out what their bodies can and can’t do. Rather than trying to control, or “fix” our body, dance is about developing greater body awareness and moving at our capacity, regardless of physical or cognitive difference.

    4    . Dancing with others not only makes people feel less different in their abilities when dealing with neurological and movement disorders, it also helps to combat the loneliness and social isolation of living with a chronic illness.

Still, researchers say they’re only scratching the surface of understanding how dance can be used therapeutically.     5    . Researchers are also trying to find out the most effective types of dance movements and the optimal length and frequency of classes.

6 . When my son Reace celebrated his sixth birthday two years ago, he made a wish that I would get a transplant. Less than a week later, his wish came true when I received new _________.

Born with a breathing disease, I was able to manage my _________ without a hospital visit until I was 23. At 30, _________, it steadily worsened and I was _________ for a transplant. I started having check-ups once a year, then every six months, then every three months until I was _________ living at the hospital and reliant on oxygen to survive. Everyday _________ like having a shower or brushing my hair became _________.

After four months on the list, I _________ the call to say a pair of lungs was available. The transplant was successful and the _________ was noticeable. Before my transplant I had been so __________, I couldn’t even walk from the couch to the front door without __________ my breath—and it was only six paces. __________, I was so used to being breathless that I didn’t know any difference. I had __________ what it would be like to be a __________ person and now I know. I can do everything an ordinary mum would do: housework, workout, or taking Reace to basketball.

I am extremely grateful to my __________ and his family.

7 . The past few months have brought electrifying news that, for the first time, a gene treatment has provided some hearing to children born with deafness.

Eli Lilly announced this week, for example, that a profoundly deaf boy from Morocco given its treatment as part of a clinical trial in Philadelphia can now hear. And five children in China treated similarly at younger ages gained hearing with some able to verbally communicate without their cochlear implants (人工耳蜗). Their hearing recovery, first covered by the press in October 2023, is described in detail this week in The Lancet.

“It’s an enormous achievement,” says geneticist Karen Avraham of Tel Aviv University. Otolaryngologist (耳鼻喉科专家) and gene therapist Lawrence Lustig of Columbia University, whose lab was among the first to test the same approach in mice, agrees. “Other than cochlear implants, we haven’t really had any successful treatments to treat deafness,” he notes.

The various efforts from companies and academic centers each use a virus to insert the same gene, OTOF, into the children’s inner ear so the so-called hair cells there can sense sound and transmit it to the brain.

The new deafness treatments add to a string of recent successes for the gene treatment field, but also raise questions. The ear’s hair cells don’t divide, so the new copies of OTOF they contain should persist and continue to instruct the cells to make OTOF. Gene expression could drop off over time or the ear could mount an immune response that shuts it off.

But Lustig is optimistic that the various challenges will be overcome. “Now that we’ve got one success story, there’s going to be more money coming in to fund some of these other projects,” he says.

Imagine for a moment that your unborn child has a rare genetic disorder. Not     1     at least vaguely familiar, such as sickle-cell anaemia or cystic fibrosis, but rather a condition     2     (bury) deep within the medical dictionary. Adrenoleukodys trophy, maybe. Or Ehlers-Danlos syndrome.

Would you, when your child is born, want to know about it? If effective treatments were available, you probably would. But if not? If the outcome were fatal, would your interest in knowing about it depend on whether your newborn had five years of life    3     (look) forward to, or ten? Or 30?

Today these questions are mostly hypothetical. Precisely because they are rare, such disorders are seldom noticed at birth. They manifest (显现) themselves only gradually, and often with unpredictable severity. But that may soon change. Twenty years after the first human genome     4     (map), the price of whole-genome sequencing has fallen to a point     5     it could, in rich countries at least, be offered routinely to newborns. Parents will then have to decide exactly how much they want to know.

Early diagnosis brings with it the possibility of early treatment. Moreover, sequencing the genomes of newborns could offer a lifetime of returns. A patient’s genome may reveal     6     drugs will work best in his or her particular case for conditions such as ADHD, depression and cancer. Combined with information about someone’s way of life, it could highlight easily neglected health risks such as cancers and cardiovascular disease, leading to better preventive measures. A database of genomes,     7     (match) to living people, would be a benefit to medical research. The fruits of that research, in turn, would make those genomes more useful to their owners as time goes on.

Such a powerful new technology create new dangers. Widespread screening for thousands of potentially harmful genes may be counterproductive: some results may worry parents unnecessarily, because some genetic variations,     8     occasionally indicative of disease, are not strongly so. Parents may not want to unlock all the secrets that their newborn’s genome might reveal. Some may indeed prefer not to know about conditions that cannot be treated. Adult-onset illnesses pose a different dilemma — a reasonable position is that it     9     be up to the children themselves, once grown, to decide whether they want to look at their genomic information. A further concern is that data will not be kept secure, and may be leaked or otherwise misused     10     some point in the future.