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题型:阅读理解-阅读单选 难度:0.65 引用次数:156 题号:19095673

Tiny sensory hair cells called stereocilia(静纤毛)located in your inner ear are responsible for detecting sound. When these become damaged, either by genetic disorders, loud sounds or old age, it can lead to hearing difficulties and even deafness.

Now, in a series of experiments on mice, researchers based at the Salk Institute for Biological Studies and the University of Sheffield have identified a protein that can be delivered to these hair cells in order to stimulate their growth. “Our discovery shows that hair cell function can be restored in certain cells,” said Dr Uri Manor, assistant research professor and director of the Waitt Advanced Biophotonics Core at Salk.

Stereocilia hair cells are found throughout the cochlea(耳蜗). Regions of the cochlea that sense low frequencies have longer stereocilia, while regions that sense high frequencies have shorter stereocilia. When sounds enter the ear, they cause fluid within the cochlea to vibrate(振动), which in turn causes the stereocilia to move. These hair cells then send signals to neurons(神经元), which pass on information about the sounds that we are hearing to the brain.

In their previous studies, Manor and Prof Walter Marotti found that the protein EPS8 was involved in determining the length of stereocilia. Without the protein, the growth of the hairs is stunted and they remain very short. For this latest study, the two researchers teamed up to design an experiment to see if adding EPS8 to stereocilia hair cells could stimulate their regrowth and improve hearing in mic. They used a common gene therapy(基因治疗)technique to deliver the protein to the hair cells on the back of a virus. They then investigated the effects using imaging techniques.

The team found that EPS8 increased the length of the stereocilia and restored their function in low-frequency cells, although not enough to restore the hearing of the mice. However, they also found that the cells seemed to lose their ability to regenerate as they aged. The researchers now plan to investigate the action of EPS8 further, with the hope of extending the age range over which it is effective.

1. What is the author’s purpose in writing paragraphs 1 and 2?
A.To reveal causes of hearing problems.
B.To show different functions of stereocilia.
C.To prove the necessity of hearing protection.
D.To introduce the finding of a hearing-improving protein.
2. What does the underlined word “stunted” in paragraph 4 mean?
A.Guaranteed.B.Prevented.C.Recorded.D.Reflected.
3. What did the researchers use the gene therapy technique to do?
A.Help mice grow faster.B.Keep viruses from growing.
C.Send EPS8 to stereocilia hair cellsD.Remove aged stereocilia hair cells.
4. What do the researchers plan to do?
A.Restore the hearing of the mice.B.Make EPS8 effective in aging cells.
C.Investigate the formation of EPS8.D.Count low-frequency cells of aging mice.

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【推荐1】For many years doctors have warned us about the dangers of stress (压力) and have given us advice about how to cut down our stress levels. Everyone agrees that long-term stress, for example having to look after someone who has a chronic (慢性的) illness, or stressful situations where there is nothing we can do, for example being stuck in a traffic jam, should be avoided whenever possible. However, some medical experts now believe that certain kinds of stress may actually be good for us.

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1. What is Dr Kyriazis' opinion probably based on?
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