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题型:阅读理解-阅读单选 难度:0.65 引用次数:94 题号:21850826

“Given that signs of Alzheimer’s disease (老年痴呆症) start to accumulate in the brain several decades before the disease begins, understanding the connection between sleep and cognition (认知) earlier in life is critical for understanding the role of sleep problems as a risk factor for the disease,” said study author Yue Leng, PhD, of the University of California, San Francisco.

The study involved 526 people with an average age of 40. They were followed for 11 years. Researchers looked at participants’ sleep duration and quality. Participants wore a wrist activity monitor for three continuous days on two occasions approximately one year apart to calculate their averages. Participants slept for an average of six hours. Participants also reported bedtime and wake-up time in a sleep diary and completed a sleep quality survey with scores ranging from 0 to 21. A total of 239 people reported poor sleep with a score greater than five.

Researchers also looked at sleep fragmentation (碎片化), a measure of restlessness during the sleep period expressed as a percentage. The higher the value, the more sleep is interrupted. Participants were divided into three groups based on their sleep fragmentation score. Of the 175 people with the most interrupted sleep, 44 had poor cognitive performance 10 years later, compared to 10 of the 176 people with the least interrupted sleep.

After adjusting for age, sex, race, and education, people who had the most interrupted sleep had more than twice the possibility of having poor cognitive performance when compared to those with the least interrupted sleep. There was no difference in cognitive performance at midlife for those in the middle group compared to the group with the least interrupted sleep.

However, due to the small sample size, the researchers were unable to fully investigate potential race or sex differences. “More research is needed to assess the link between sleep disturbances and cognition at different life stages and to identify if critical life periods exist when sleep is more strongly associated with cognition,” Leng said.

1. What do we know about Yue Leng’s study?
A.Data collection was an easy process.B.It aimed to find a cure for Alzheimer’s.
C.The results were far from satisfactory.D.Higher scores mean poorer sleep quality.
2. What can we learn about sleep fragmentation in the study?
A.It did require outside intervention.B.It included a series of memory tests.
C.It measured short interruptions of sleep.D.It determined those participants’ groups.
3. What do the findings indicate according to the text?
A.The quality of sleep may affect cognitive health.
B.Keeping a sleep diary can improve one’s sleep quality.
C.People sleeping well won’t suffer from Alzheimer’s disease.
D.People with interrupted sleep won’t have memory problems.
4. What is the last paragraph mainly about?
A.The major limitation of the study.
B.An explanation of the research method.
C.A possible reason for the study findings.
D.The use of careful investigations in real life.
【知识点】 科普知识 说明文

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【推荐1】Nicotine is the addictive chemical in tobacco smoke and e-cigarette vapors. And doctors say a teen’s brain is no place for it to end up. Nicotine can reach the brain within seven seconds of smoking a cigar, cigarette or electronic cigarette.

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Some of the negative effects of nicotine on the young brain will fade with time — if exposure ends. Others, however, may persist. For instance, brain scientists at VU University Amsterdam found that exposing adolescent rats to nicotine increased their aggressive behavior. It made them a bit more reckless than usual. It also made it harder for them to focus their attention—even later, as adults

No one is sure that the same thing happens in humans, but that’s exactly what worries Garry Sigman. “Exposing the developing adolescent brain to nicotine could lead to a high risk of lifelong addiction,” he explains.

1. What do we know about the prefrontal cortex?
A.It controls personality and the brain.B.It regulates emotions and behaviors.
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A.Teenagers have fewer receptors in the brain.
B.Nicotine does not reach the brain quickly enough.
C.The brain creates more receptors to handle nicotine.
D.Nicotine has a greater effect on teens’ prefrontal cortex.
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