An era in which an Alzheimer’s (阿尔兹海默) diagnosis can begin in a doctor’s office is now arriving. Advances in technologies to detect early signs of disease from a blood sample are helping doctors to identify the memory-robbing disorder more accurately and to screen participants more quickly for trials of potential treatments for the more than five million people in the U.S. afflicted with Alzheimer’s. Estimates predict that, by 2030, there will be 76 million people worldwide who will receive a diagnosis of Alzheimer’s or other dementias.
Last fall, a blood test developed by C2N Diagnostics in St Louis, Mo., became available to most of the U.S. as a routine lab test—regulated under the CMS Clinical Laboratory Improvement Amendments (CLIA) program. It has also received a CE mark as a diagnostic medical device in the European Union—indicating it has met safety, health and environmental protection standards for the region.
“The development of a blood-based test for Alzheimer’s disease is just phenomenal,” says Michelle Mielke, a neuroscientist and epidemiologist at the Mayo Clinic. “The field has been thinking about this for a very long time. It’s really been in the last couple of years that the possibility has come to fruition.”
The C2N test, called PrecivityAD, uses an analytic technique known as mass spectrometry (质谱分析技术) to detect specific types of beta-amyloid (β-淀粉样蛋白), a protein fragment that is a pathological (病态的) hallmark of disease. Beta-amyloid proteins accumulate and form plaques (斑块) visible on brain scans two decades before a patient notices memory problems. As plaques build up in the brain, levels of beta-amyloid decline in the surrounding fluid.
Such changes can be measured in spinal (脊髓的) fluid samples—and now in blood, where beta-amyloid concentrations are significantly lower. PrecivityAD is the first blood test for Alzheimer’s to be cleared for widespread use and one of a new generation of such assays that could enable early detection of the leading neurodegenerative disease—perhaps decades before the onset of the first symptoms.
1. According to the blood test developed by C2N Diagnostics, we can know that ________.A.it can be applied in a few areas in the United States |
B.it was carried out under the supervision of under the CMS’s program |
C.it obtained the CE mark issued by the United States for diagnostic medical equipment |
D.it has reached the safety, health and environmental protection standards of the world |
A.Supportive. | B.Opposed. | C.Cautious. | D.Wait-and-see. |
A.samples | B.experiments | C.changes | D.symptoms |
A.by 2030, more people around the world will suffer from Alzheimer’s disease or other dementia |
B.as plaques accumulate in the brain, the level of beta-amyloid protein in the surrounding fluid will rise |
C.Alzheimer’s patients are expected to be diagnosed decades before the initial symptoms appear |
D.many blood tests for Alzheimer’s disease are under development now |
相似题推荐
【推荐1】If you have flown with JetBlue or Delta airlines lately, you might recall a new program that allows passengers to board their flights with a facial recognition scan. However, you might not have known that these systems were also the first stage of the Department of Homeland Security’s (DHS) “Biometric Exit” program, which has been in place since June of last year, Slate reports.
According to Slate, the DHS has partnered with Delta to make face recognition scans mandatory (强制的) for certain international flights leaving Atlanta and New York. DHS is also working with JetBlue to develop a similar system for travelers flying from Boston to Aruba.
So, how does it work? Essentially, computers “match passport and visa photos of U.S. visa holders to photos taken at the airport from which they’re departing the country,” Mashable says. “This helps the U.S. make sure the people getting on the plane are the same people who hold those visas.”
Still, the two programs are slightly different. The Delta system compares a photo of the passenger’s face, taken by a kiosk (信息服务亭) at the boarding gate, to photos from State Department databases. It also checks passengers’ citizenship or immigration (移民) status. If you’re flying with JetBlue, you can voluntarily get your face scanned instead of using a physical ticket.
And these systems aren’t going away anytime soon; in fact, the program is expected to expand in the coming years. Homeland Security is currently negotiating to make face recognition a common feature across all American TSA security checkpoints, says U.S. Customs and Border Protection executive John Wagner.
1. Who should go through the new security system?A.Passengers who fly from Boston to New York. |
B.All passengers entering the U.S. |
C.Passengers of certain international flights. |
D.All American passengers. |
A.The metal detectors. |
B.The airport security lines. |
C.TSA security checkpoints. |
D.The facial recognition systems. |
【推荐2】Microsoft has developed a new smart phone app that interprets eye signals and translates them into letters, allowing people with motor neurone disease to communicate with others from a phone.
The GazeSpeak app combines a smartphone’s camera with artificial intelligence to recognize eye movements in real time and convert(改变) them into letters, words and sentences.
For people suffering from ALS(渐冻症), also known as motor neurone disease, eye movement can be the only way they are able to communicate.
“Current eye-tracking input systems for people with ALS or other motor impairments are expensive, not robust under sunlight, and require frequent re-calibration and substantial, relatively immobile setups,” said Xiaoyi Zhang, a researcher at Microsoft who developed the technology.
“To mitigate the drawbacks…we created GazeSpeak, an eye-gesture communication system that runs on a smartphone, and is designed to be low-cost, robust, portable and easy to learn.”
The app is used by the listener by pointing their smartphone at the speaker. A chart that can be stuck to the back of the smartphone is then used by the speaker to determine which eye movements to make in order to communicate.
The sticker shows four grids(方格) of letters, which each correspond to a different eye movement. By looking up, down, left or right, the speaker selects which grids the letters they want belong to. The artificial intelligence algorithm(程序) is then able to predict the word or sentence they are trying to say.
1. What does the underlined word “mitigate” in paragraph 5 probably mean?A.ignore | B.destroy |
C.increase | D.reduce |
A.The advantages of Gaze Speak over the Current eye-tracking input systems. |
B.Smartphone App helps ALS suffers speak with their eyes movement. |
C.The sticker plays an important role in Gaze Speak. |
D.The writer is making an advertisement for Gaze Speaker. |
A.doubtful | B.negative |
C.favorable | D.unclear |
【推荐3】As a greenhouse gas,carbon dioxide-or CO2-helps warm the atmosphere. But too much of that gas has been driving an atmospheric fever. Recently, a team of researchers found a way to turn CO2 into a useful product. The researchers are turning CO2 into ethanol(乙醇) which is often added to gasoline. Although adding ethanol reduces the energy in gasoline, it offers a nice tradeoff: it helps gasoline burn more cleanly. So making ethanol from CO2 would be better for the environment.
To do that, the researchers developed a brand-new catalyst(催化剂)which could accelerate the chemical reaction. With it, the voltage(电压)needed to start the new CO2-to-ethanol reaction is far less than what's needed to start similar reactions. And although chemical reactions often make many unwanted byproducts, this new one does not. More than 90 percent of the final product is ethanol.
The new catalyst uses a bed of carbon to support copper atoms(铜原子).Those copper atoms are spread out. When electricity runs through the catalyst,copper atoms join up, forming groups of 3 or 4 atoms. By firing powerful X-rays at them, the research team could “monitor the chemical reaction as it happens”. Those atom groups activate the catalyst, helping the CO2 react with water. The CO2 now divides into carbon and oxygen atoms. And the water divides into hydrogen and oxygen atoms. All of these freed atoms now rearrange themselves to form ethanol.
Although many scientists describe the new process as “very cool”, they are still a bit skeptical. “A closer look at the reaction is needed,” chemist Anna Klinkova says. “It could be more complex than what is presented.” The researchers are continuing to experiment with the new process. They also hope to make other useful materials from carbon dioxide. “That's why the new study isn't a final step,” a researcher says. “This is just the beginning of this long research journey. ”
1. Why is ethanol added to gasoline?A.To make driving less costly. |
B.To turn CO2 into clean energy. |
C.To reduce the gasoline consumption. |
D.To lessen the harm of gasoline burning. |
A.It gives off little CO2. |
B.It is environment-friendly. |
C.It increases the output rate. |
D.It lowers the voltage in the reaction. |
A.By using X-rays. |
B.By dividing CO2. |
C.By joining up copper atoms. |
D.By rearranging the atoms in CO2. |
A.Supportive. |
B.Doubtful. |
C.Negative. |
D.Particular. |
【推荐1】Migration (迁移) has become a flashpoint for debate in many countries. But research from the McKinsey Global Institute(MGI) finds that it generates significant economic benefits-and more effective integration of immigrants (移民) could increase those benefits.
Moving more labor to higher-productivity settings boosts global GDP. Migrants of all skill levels contribute to this effect, whether through entrepreneurship (创业) or through freeing up natives for higher-value work. In fact, migrants make up just 3. 4 percent of the world’s population, bur MGI’ research finds that they contribute nearly 10 percent of global GDP. They contributed roughly $6. 7 trillion to global GDP in 2015-some $3 trillion more than they would have produced in their origin countries. Developed nations realize more than 90 percent of this effect.
Employment rates are slightly lower for immigrants than for native workers in top destinations, but this varies by skill level and by region of origin. Wide-ranging academic evidence shows that immigration does not harm native employment or wages, although there can be short-term negative effects if there is a large inflow of migrants to a small region, if migrants are close substitutes for native workers, or if the destination economy is experiencing a downturn.
Realizing the benefits of immigration depends on how well new arrivals are integrated (融合) into their destination country’s labor market and into society. Today immigrants tend to earn 20 to 30 percent less than native-born workers. But if countries narrow that wage gap to just 5 to 10 percent by integrating immigrants more effectively across various aspects of education, housing, health, and community engagement, they could generate an additional boost of $800 billion to $1 trillion to worldwide economic output annually. This is a relatively conservative goal, but it can produce broader positive effects, including lower poverty rates and higher overall productivity in destination economies.
The stakes are high. The success or failure of integration can reverberate (回荡) for many years, influencing whether second-generation immigrants become fully participating citizens who reach their full productive potential or remain in a poverty trap.
1. What is the purpose of this text?A.To give a definition. |
B.To explain a phenomenon. |
C.To introduce a research. |
D.To report a finding. |
A.Around $3 trillion of 2015 global GDP would have disappeared without immigration. |
B.90 percent of 2015 global GDP was created by immigrants from developed nations. |
C.20 to 30 percent native-born workers earn 10% more than immigrants. |
D.$800 billion to $1 trillion would be boosted if immigrants earned 20-30% more. |
A.How skilled immigrants are. |
B.How much immigrants make up the local population. |
C.How good the destination economy is. |
D.How integrated immigrants are into local society. |
A.immigration | B.integration |
C.contribution | D.second-generation |
![](https://img.xkw.com/dksih/QBM/2020/12/25/2621968998187008/2627513719889921/STEM/9bd5ead867994e30b3f1b5cb5d7dfbe5.png?resizew=644)
![](https://img.xkw.com/dksih/QBM/2020/12/25/2621968998187008/2627513719889921/STEM/b4bbc1bc693741ef8828a534de3f9f82.png?resizew=665)
1. How should we read the following sentence with proper pauses?
A.Buffalo buffalo Buffalo/ buffalo buffalo/ buffalo Buffalo buffalo. |
B.Buffalo buffalo/ Buffalo buffalo buffalo/ buffalo Buffalo buffalo |
C.Buffalo buffalo Buffalo/ buffalo buffalo buffalo/ Buffalo buffalo. |
D.Buffalo buffalo/ Buffalo buffalo/ buffalo buffalo Buffalo buffalo. |
A.The relative pronouns in English can be omitted. |
B.In English, place names can be used as adjectives. |
C.The city has the same name with a kind of American bison. |
D.The word buffalo has the same form of singular and plural. |
A.Wandering the Earth |
B.Linguistics Around Us |
C.Popular Animal Science |
D.Collins English Grammar |
【推荐3】Previous studies have found that the number of years spent in school relates to cognition (认知) later in life, but few studies have examined the influence of educational quality.
“Our study establishes a link between high-quality education and better later-life cognition and suggests that increased investment in schools could be a powerful strategy to improve cognitive health among older adults in the United States,” said Jennifer Manly, senior author of the study.
The study, led by Manly and Dominika Šeblová, a postdoctoral research scientist at Columbia, used data from Project Talent, a 1960 survey of high school students across the United States, and follow-up data collected in the Project Talent Aging Study. The researchers examined the relationships between six indicators (指标) of school quality and several measures of cognitive performance in participants nearly 60 years after they left high school. Since high-quality schools may be especially beneficial for people from disadvantaged backgrounds, the researchers also examined whether associations differed by geography, gender, race and ethnicity.
The researchers found that attending a school with a higher number of teachers with graduate training was the most consistent predictor of better later-life cognition, especially in language fluency (for example, coming up with words within a category). Attending a school with a high number of graduate-level teachers was about equal to the difference in cognition between a 70-year-old and someone who is one to three years older. Other indicators of school quality were related to some, but not all, measures of cognitive performance.
According to Manly and Šeblová, there may be many reasons explaining why attending schools with well-trained teachers may affect later-life cognition. “Instruction provided by more experienced and knowledgeable teachers might be more intellectually inspiring and provide additional neural or cognitive benefits,” said Šeblová, “and attending higher-quality schools may also influence life track, leading to university education and greater earnings, which are in turn linked to better cognition in later life.”
1. What is the author’s purpose in writing the text?A.To remind the public of seniors’ health. | B.To look into investment in schools. |
C.To achieve the fairness of humans. | D.To attach importance to education. |
A.By conducting surveys. | B.By making comparisons. |
C.By explaining examples. | D.By interviewing the disabled. |
A.The physical health determines your future life. |
B.Good education contributes to good later-life cognition. |
C.Language fluency is based on postgraduate training. |
D.Good schools should have many well-trained teachers. |
A.Favorable. | B.Doubtful. | C.Uncaring. | D.Opposing. |