1 . Chinese scientists have identified a new protein that restricts HIV infection, a discovery that could pave the way for the development of new drugs against the virus. The protein, P-selectin glycoprotein ligand 1 (PSGL-1), which exists in human cells, can inhibit (抑制) the process by which HIV reproduces, according to research published in the science journal Nature Microbiology this month.
However, the study also showed that PSGL-1 can be negatively affected by Vpu — an accessory (附属) protein of HIV — which can neutralize the ability of PSGL-1 to resist HIV. Further research is under way to develop a drug that can inhibit the HIV protein so that PSGL-1 can restrict HIV, according to Tan Xu, a researcher at Tsinghua University's School of Pharmaceutical Sciences, a leading author of the study.
Several other proteins in human cells that could resist HIV have been discovered over the past 10 years, but the virus can also evade (避开) them. PSGL-1 shows particular promise in that it can inhibit HIV in multiple ways — especially by blocking the infectiousness of virus offspring, Tan said.
“We are starting to research into small molecule (分子) compounds in the hope of finding one that can restore PSGL-1’s anti-HIV function. In this way, we can develop a very effective antiviral drug for people with HIV/AIDS,” he said. Tan said it will require at least three to five years for the research to reach the preclinical stage, and more time after that before a clinical trial is possible. The research was conducted by researchers at Tsinghua University in Beijing, Fudan University in Shanghai and George Mason University in the United States.
Existing treatment methods for people with HIV/AIDS, which mostly rely on a combination of different drugs, can prevent the disease from progressing but cannot cure it, and long-term use of drugs can result in drug resistance.
An estimated 37 million people in the world live with HIV, according to the Joint United Nations Programme on HIV/AIDS. The study provides new leads to developing antiviral drugs, Tsinghua University said in a statement.
1. What can we learn about PSGL-1 from the passage?| A．Both the protein PSGL-1 and the protein Vpu are HIV proteins. |
| B．PSGL-1 can restrict the function of the protein Vpu. |
| C．PSGL-1’s molecule compounds have been identified. |
| D．The protein PSGL-1 functions better than others in resisting HIV. |
| A．The existing treatment for AIDS are far from perfect. |
| B．It will be a decade before the antiviral drugs is put on the market. |
| C．American scientists played a leading role in the research. |
| D．HIV/AIDS will no longer be a deadly problem owing to the new discovery. |
| A．There is a long way to go before curing AIDS. |
| B．More people are faced with the threat of HIV. |
| C．Chinese scientists are leading the way in curing AIDS. |
| D．A new protein to resist HIV was confirmed by scientists. |
| A．A guidebook. | B．A fiction. | C．A magazine. | D．A brochure. |
2 . Many people think that the world is about to step into the fourth industrial revolution. This time, machines can do a lot of work in the charge of human beings, even better than human beings. In the future, the world can be more efficient and enjoy cheaper services, but unemployment will become more common.
It raises a troubling question for all of us — when will a machine be able to do my job? Katja Grace, a research associate at the University of Oxford’s Future of Humanity Institute, and her colleagues from the AI Impacts project and the Machine Intelligence Research Institute, have surveyed 352 scientists and compiled (汇编) their answers into predictions about how long it may take for machines to outperform humans on various tasks.
The good news is that many of us will probably be safe in our jobs for some time to come. The researchers predict there is a 50% chance that machines will be capable of taking over all human jobs in 120 years.
“One of the biggest surprises was the overall lateness of the predictions,” says Grace. “I expected the amazing progress in machine learning in recent years, plus the fact that we were only talking to machine learning researchers, to make the estimates earlier.”
“I am a bit sceptical of some of the timelines given for tasks that involve physical manipulation (操纵),” says Jeremy Wyatt, professor of robotics and artificial intelligence at the University of Birmingham. “It is one thing doing it in the lab, and quite another having a robot that can do a job reliably in the real world better than a human.”
Manipulating physical objects in the real world — figuring out what to manipulate, and how, in a random, changing environment — is an incredibly complex job for a machine. Tasks that don’t involve physical manipulation are easier to teach.
Perhaps the hardest jobs for machines to perform are those that take years of training for humans to excel at. These often involve intuitive (直觉的) decision making, complex physical environments or abstract thinking — all things that computers struggle with.
1. Why did the researchers conduct the survey on the future role of machines?| A．To make it clear how machines can replace humans. |
| B．To find why machines can take the place of humans. |
| C．To explain humans will be substituted by machines. |
| D．To learn when machines may be superior to humans on jobs. |
| A．She thought the time would be totally uncertain despite the survey. |
| B．She thought the time would be later than predicted. |
| C．She thought the time would be earlier than predicted. |
| D．She thought machines would take over all the jobs in 120 years. |
| A．A robot can do a job reliably in the real world better than a human. |
| B．Tasks that don’t involve physical manipulation are quite complicated. |
| C．It is difficult for robots to finish the jobs related to physical manipulation. |
| D．He is sure of the timelines given for tasks that involve physical manipulation. |
Tears are good for your eyes. In fact, without them, your eyes wouldn’t even be able to move. Some people say tears help us in other ways, too. Maybe you know someone who likes to watch sad movies in order to “have a good cry”. It hasn’t been proven, but tears may be good not only for your eyes but also for your emotional health as well.
We generally only notice tears when we cry, but we have them in our eyes all the time. Tears affect how we see the world while at the same time protecting our eyes from it. Without this liquid covering them, our eyes would be at risk of infection. In addition, we need tears in order to see. The cornea (角膜) of the eye does not have a perfectly smooth surface. Tears fill in the holes in the cornea and make it smooth so that we can see clearly. Without tears, the world would look very strange to us.
There are three types of tears, and they are called basal, reflex, and emotional tears. These three types are different not only in purpose but also in composition.
Tom Lutz, the author of Crying: The Natural and Cultural History of Tears, writes, “Throughout history, and in every culture, ... everyone everywhere cries at some time.” Even men and women who say they never cry can usually remember crying as children. Most of us probably think it’s normal for men or women to cry at certain times, and at such times, we may even encourage them to cry. For example, it’s no surprise when someone cries during a sad movie, and we often expect people to cry when a family member dies. However, we don’t always take this view of tears. Sometimes adults who cry — or even children who do — lose the respect of others. For example, what would you think of an adult who cried over losing a card game? Most people are aware of the social rules about when, where, and why it’s OK to cry. These rules generally differ for children and adults, and often for men and women. They depend on things such as family, culture, and religion, and they change over time.
Some people think it’s not just OK to cry but actually healthy to let the tears flow. Doctors in Greece over 2,500 years ago thought that tears came from the brain and that everyone needed to let them out. Today, many people still believe in getting tears out. They say that through crying, we get rid of emotions we have stored up, which is good for our mental health. Some people report that they feel better after crying. This could be because of the chemicals in emotional tears. One chemical is a type of endorphin, a painkiller that the body naturally produces. Emotional tears increase the amount of endorphin that gets to the brain because tears flow from the eye into the nose and pass to the brain that way. This painkiller may make a person less aware of sad or angry feelings, and that could explain why someone feels better after “a good cry”.
1. When do we have tears in our eyes?
2. How do tears help us see clearly?
3. How many kinds of tears do we have?
4. Please list at least two things that are related to the social rules of crying.
5. In which country did doctors over 2,500 years ago believe that tears came from the brain?
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DJ: Hello. A lot of you have probably just got your A-levels and you’re looking forward to going to university. But more and more young people are deciding to take a gap year before they start their degrees. Today I’m talking to a group of young people who’ve all decided to take a year out before they go to university. What are they going to do? Rosie? What are your plans?
Rosie: I’m going to work in a department store.
DJ: Why do you want to do that?
Rosie: Two reasons really. I’m going to study Management at university and this will give me the chance to find out what it’s like to work in a big organization. And I’ll also be able to earn some money.
DJ: What about you, Christopher?
Christopher: I’m going to do community work with a conservation group. I think it’ll be good to do something really useful. And I’ll meet a lot of interesting people, I’m sure.
DJ: Will you get paid for it?
Christopher: Well, we won’t get rich doing it, but we’ll be all right. We’ll get about £20 a week plus food and accommodation.
DJ: Helen, what are you going to do?
Helen: I’m going to travel around Europe.
DJ: Are you going to work there?
Helen: I hope so, or I’ll have to come home again. I might try and get a job—you know—in a hotel or something like that.
DJ: Why do you want to do it?
Helen: Well, mainly because it’ll be a change. After all, I’ve been at school for 13 years. I just want to do something different. It’ll give me new experiences and I’ll need to be more independent.
Note: A-levels英国普通中等教育证书考试高级水平课程, 也是英国学生的大学入学考试。
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缺词: 在缺词处加一个漏字符号 (^), 并写出该词;
多词: 把多余的词用斜线 (\) 划掉;
错词: 在错词下划一横线, 并写出改正后的词。(答案写在答题纸上)
| 例如: One of my favorite writers are Charlotte Bronte. She was born in the early nineteenth is century when women had far fewer opportunities ^ they have now. She lived in a than  small village in Yorkshire and she took great pleasure in walking on the moors wherenear her home. |
A concert violinist went to New York City to play at Carnegie Hall. It was his one visit to the city, so he got lost on the way from his hotel to the concert. After wandering up or down several streets, he decided to ask for directions. “Excuse me,” he said to a woman on the corner. “How do I get to Carnegie Hall?” The woman looked at the man hold his violin case and answered, “Practice, practice, practice.”
In this old joke, “get to Carnegie Hall” has two meanings: (1) arrive at the building called Carnegie Hall; (2) reach the top of the music profession, symbolized by Carnegie Hall. To perform at Carnegie Hall is a honor for any musician. It’s the highlight of his or her career. It true takes a lot of practice and hard work to be good enough to play at Carnegie Hall.
Carnegie Hall was built by Andrew Carnegie, one of the richest men of his time. It opened in May of 1891. It’s famous for its superb acoustics (音响设计), which make it a wonderful place to both perform and listen to music-all type of music. The famous Russian composer Tchaikovsky played there, and so do the Beatles.
Since the opening night over 100 years ago, many prominent classical, jazz, and pop musicians performed at Carnegie Hall. No matter what they arrived on the night of their performances such as by subway, taxi, or on foot, they all got to there by dedication to their art, talent-and practice, practice, practice.
A． | B． | C． | D． | E． |
