1 . In early July, FDA granted traditional full approval of Leqembi for the treatment of Alzheimer’s disease (AD). This is the first approved medication proven to slow the progression of AD’s clinical symptoms. A phase three trial among 50-to-90-year-old patients with early AD showed that it can do so by about 27% over an 18-month period. While we cannot extrapolate (推断) beyond 18 months, this represents about a six-month delay in progression of AD symptoms.

A second disease-slowing drug, donanemab, has recently shown similar effects and may get FDA approval by the end of the year.The development of Leqembi is a notable success for medical science in that a disease previously impervious to any disease-modifying medical intervention now has an available, effective treatment. However, paraphrasing Winston Churchill, this is not the beginning of the end but the end of the beginning. The drug does not reverse disease symptoms or prevent progression, it slows progression. And there are considerations that make it inappropriate for many patients with AD. It does, however, lay the groundwork for future AD medications that could alleviate (减轻) suffering from this devastating disease for generations to come.

An important factor for new drugs is their cost. Leqembi’s price tag is $26,500 per year — much more than the current symptomatic medications for AD but comparable or less expensive than new medications for other conditions, for example multiple sclerosis or ALS.

Medicare has announced that it will provide coverage for this medication, although it is requiring that physicians perform certain clinical measures and enter the patient’s data in a registry in order for the drug to be covered, which will increase physician and patient burdens. What’s more, traditional Medicare only covers 80% of outpatient costs, so for those patients without supplemental insurance, a 20% copay for the drug and required MRI scans (核磁共振扫描) might amount to up to $10,000 or more per year out of pocket, but still only a fraction of the cost of a year of in a nursing home.

1. What can we learn from the first two paragraph?

A．Leqembi can make a six-month delay of AD’s symptoms over a two-year period.

B．To some degree, Leqembi is effective to slow the progression of AD symptoms.

C．Both donanemab and Leqembi have got FDA approval.

D．The drug is appropriate for any patient with AD.

2. The underlined sentence in Paragraph 2 means _____ in the passage.

A．although the new drug has undergone trials, it is still not effective enough

B．though Leqembi can slow the progression of AD’s symptoms, we still have a long way to go

C．the research of the Leqembi will come to an end

D．some others problems related to the the medicine have been caused

3. Leqembi’s price is _____ according to the passage.

A．much cheaper than other medications for AD

B．much more than current medications for other conditions

C．affordable to almost every patient

D．cheaper than new medications for ALS

4. Medicare will provide coverage for this medication on condition that _____.

A．physician and patient burdens are increased

B．patients do not have supplemental insurance

C．patient’s data is registered and clinical measures are carried out by doctors

D．patients pay the cost of a year of in a nursing home

2 . Alexis was a student, the only son of his wealthy parents, and felt entitled to the luxuries he had in his life. On a class field trip, Alexis met the forester, Justin, who had been living in a wooden house in the forest over ten years. When learning Justin’s life, Alexis laughed at him with his friends.

During the field trip, Alexis and his classmates passed by an entrance to a cave. “This looks so cool!” Alexis exclaimed. He wanted to go inside the cave, but his teacher stopped him.

The next day, Alexis reached the cave with his four friends, only to find they couldn’t take their schoolbags through the entrance. One by one, the teenagers entered the cave and were amazed to see how wide it was from the inside. Albert picked a large stone up and hit one of the walls with it. “This place is so cool!” he laughed quietly before the rocks from the wall came falling.

“Watch out, Albert!” Alexis said and pulled Albert towards himself. The teenagers screamed in fear when they saw the rocks fall. They couldn’t see anything because of the dust floating in the air.

The friends were scared when they realized they were trapped in the cave. “HELP! WE ARE STUCK!” the teenagers started screaming for help, hoping someone would hear them.

Fate sent Justin to the cave. The forester picked berries every day from the trees near the cave. While he was walking back to his house, five bright-colored schoolbags caught his attention. Then he approached the cave and shouted, “Hey! Who’s in there?”

“I’m Alexis ! I came here yesterday with my teacher! Help us, please! We are stuck!”

“Okay, calm down, children! I’ll help you out!” Justin said.

Justin quickly called 911 and informed them about the kids in the cave. Thinking the paramedics (护理人员) would take at least twenty minutes to arrive, he decided to help the kids himself before it was too late. Justin quickly grabbed a shovel and a flashlight and rushed back to the cave’s entrance. Meanwhile, Alexis and his friends tried to stay calm. A few minutes later, Alexis and his friends could see the flashlight shine through the cave’s entrance. Seconds later, they rushed outside the cave and took a deep breath in the fresh air.

Just then, the paramedics arrived.

1. What may lead to Alexis looking down on Justin?

A．His lower education.	B．His poor family.
C．His bad reputation.	D．His living condition.

2. How did Alexis feel about the cave at first?

A．Doubtful.

B．Curious.

C．astonished.

D．Scared.

3. Why did Justin appear near the cave?

A．It was his daily routine.	B．He saw five colorful schoolbags.
C．He came to look for the children.	D．He heard the screaming for help.

4. What lesson can we learn from the story ?

A．Lucky or unlucky.	B．Don’t judge a person by his looks.
C．Curiosity kills the cat.	D．Once in a blue moon.

3 . Most Popular UK Destinations for a Staycation

Looking for a cheap stay cation to brighten up your winter? Here are the most popular destinations in the UK.

Blackpool

Whether you’re seeking the thrills of Blackpool Pleasure Beach or are keen to catch a glimpse of Blackpool Tower, the city’s most appealing attraction, the seaside town offers various amazing views. It’s no wonder the town has gained 980.8 million views on TikTok. With accommodation price £75 for a night, you’ll have a golden opportunity to enjoy Blackpool's Illuminations (彩灯) display and the Seaside Trail.

Searborough

North Yorkshire’s Scarborough sees 49,500 monthly searches and 686.4 million views on TikTok. One of the local highlights is the annual St Nicholas Fair. While a one-night stay in Scarborough costs £85, the town offers holiday-makers opportunities to experience ancient British culture at the 12th-century castle ruins.

Swansea

The Welsh town sees 27,100 monthly searches and has 622.4 million views on TikTok. Swansea’s Waterfront Wonderland brings with it the Alpine Village and various amusement attractions. Spending a night here costs just 10 pounds more than in Scarborough. But if you book a week earlier, you can get a 5 percent discount in total. With Cardiff only being an hour’s drive from Swansea, you have the perfect opportunity to catch a game of ice hockey.

Bournemouth

Bournemouth isn’t called Sunny Bournemouth for nothing, as holiday-makers can enjoy breathtaking views along the Jurassic Coast. With a World Heritage Site within its borders, it’s no surprise to see this town with the high number of views on TikTok (868.3 million). A one-night stay will cost you £105, giving you the perfect opportunity to get relaxed.

1. What is the most attractive in Blackpool?

A．Blackpool Pleasure Beach.	B．Blackpool Tower.
C．The Illuminations display.	D．The Seaside Trail.

2. How much will a tourist at least pay for a night in Swansea?

A．£ 70.

B．£ 85.

C．£ 85.75.

D．£ 90.25.

3. Which of the following has the second-highest number of views on TikTok?

A．Blackpool.

B．Swansea.

C．Scarborough.

D．Boumemouth.

4 . 阅读下面短文，在空白处填入1个适当的单词或括号内单词的正确形式。

Wearing Hanfu and sitting in front of a Chinese zither (筝), Peng Jingxuan, a young Chinese student, moves her fingers gently along the strings on a street in Paris, France.

Peng has shared more than 200     1     (origin) videos online, with the most popular one featuring the theme song of the movie A Chinese Ghost Story viewed over 16.61 million times. “I love how she’s representing her culture in a     2     (set) where people are not familiar with it. You can tell she’s proud of her background and her music,” one of her fans commented.

Chinese zither (筝), or guzheng, is an ancient musical instrument with 21-26 strings and a length of 1.63 meters. Peng     3     (fall) in love with it when young and has been practicing it for years. Hardly finding Chinese instruments     4     (play) on the streets in Paris, she took along her guzheng     5     began her street performances to sharpen her skills. The more she performed, the more she felt a greater sense of responsibility     6     (spread) Chinese music and culture.

Considering her audience’s     7     (unfamiliar) with Chinese songs, Peng made adaptations, for     8     she received positive responses. She also performed Western pop songs that local people could relate     9    , entertaining them with beautiful melodies in a     10     (refresh) style.

5 . 听下面一段独白，回答以下小题。
1. What did Jeff Masters say about models used to predict floods?

A．They were based on short-term records.

B．They were not enough to help handle a new climate.

C．They reflected climate changes over the past decade.

2. Which state was hit by Hurricane Ida?

A．Oregon.

B．Washington.

C．Louisiana

3. How much rainfall was predicted in New York on June 12th, 2022?

A．3 to 6 inches.

B．6 to 9 inches.

C．9 to 10 inches.

4. What effect did the Yellowstone floods cause?

A．Over 600 homes were damaged.

B．Roads and bridges were shut.

C．Some people died.

6 . My name is Carmen Cruz and I am seventy-seven years old. Two years ago, I was diagnosed (诊断) with early-stage Alzheimer’s disease. A few years prior, I ________ that I was ________ parts of my daily routine, and was tested. To my ________, the results were negative. A year later, I ________ noticed bouts (发病期) of forgetfulness, only this time they were more ________. Again I requested the appropriate ________, and this time, it was ________ that I had early signs of Alzheimer’s disease.

Despite Alzheimer’s intention to rob (剥夺) me of my experiences, I have triumphed (成功) since my diagnosis.

The first thing I did was to ________ my reality. I absorbed all the information I could find, ________ the doctor’s recommendations, and committed to ________ them out. I am determined to fight, the ________ of what the disease wants me to do. And with my family’s ________, I continue each day living life to the fullest of my abilities.

Upon being diagnosed, I made it my goal to write the story of my life and I managed to complete this task in one year’s time. It was an incredible ________; I put my mind to work at full speed.

I’m ________ that in my situation, the disease is progressing extremely slowly. The final stage may be unavoidable, and as human beings, we can only do so much. However, in pursuing ________ tasks that put your mind to work, you make the most of the life you have.

1.

A．noticed

B．disagreed

C．wondered

D．reported

2.

A．establishing

B．breaking

C．forgetting

D．following

3.

A．regret

B．relief

C．anger

D．doubt

4.

A．seldom

B．even

C．again

D．soon

5.

A．normal

B．preventable

C．natural

D．frequent

6.

A．explanation

B．changes

C．treatment

D．tests

7.

A．hoped

B．mistaken

C．confirmed

D．recommended

8.

A．accept

B．explore

C．ignore

D．appreciate

9.

A．talked about

B．passed on

C．gave up

D．listened to

10.

A．living

B．seeking

C．sorting

D．leaving

11.

A．result

B．opposite

C．cause

D．truth

12.

A．permission

B．guarantee

C．advice

D．support

13.

A．effort

B．dream

C．moment

D．promise

14.

A．anxious

B．fortunate

C．depressed

D．afraid

15.

A．dangerous

B．enjoyable

C．troublesome

D．accessible

7 . 阅读下面短文，在空白处填入1个适当的单词或括号内单词的正确形式。

Dr Hart, a psychologist, interviewed three people     1     (discover) what “me” means and how they have learnt to appreciate the beauty in themselves.

Wanting to look good and obtain the praise of others, 24-year-old Jade has become     2     (addict) to selfie apps that can remove her freckles, en large her eyes and even slim her jawline. She spends     3     (hour) every day editing and posting her selfies, expecting “likes” to boost her     4     (confident). In Dr Hart’s opinion, people     5     pretend to be someone they are not tend to misjudge themselves.

Never really     6     (care) about his appearance, Anthony only used to have five identical pairs of trousers and five identical shirts. His roommates at college registered him for a TV programme, A New You. Surprised at     7     good he looked after a makeover, he realised the importance of external beauty.

Emma     8     (bother) by her “big” body shape since she was little. She made every effort imaginable to lose weight, including dieting and weight-loss pills, but this brought her nothing but pain     9     poor health. Her idea of beauty shifted when she came across the inspiring success story of Tess Holiday, a plus-size model. And she has acknowledged that keeping fit not only makes us much    10     (beautiful), but happier, too.

8 . Art and culture should care about the existence of human beings, that is to say, the development of art and culture should be ______ human existence.

A．in charge of

B．in control of

C．in harmony with

D．in communication with

9 . Videos showed that teachers interacted with the whole class 72 percent of the time in Chinese classrooms, ______ only 25 percent in England.

A．in response to

B．in competition with

C．in return for

D．in comparison with

10 . If you cannot ______ your emotions in the case, it is unlikely that you will deal with it fairly.

A．take advantage of

B．get rid of

C．put up with

D．keep pace with