3 . Scientists have known for decades that having measles suppresses(抑制) kids’ immune systems for several weeks or months, leaving them ill-equipped to fight off pneumonia, bronchitis and other infections.
Now a team of researchers has suggested that the measles virus may also leave a longer-lasting sort of “immune-amnesia” that makes it harder for people to stave off other illnesses for two years or more.
That re-emphasizes the importance of vaccination(接种疫苗), said biologist Michael Mina, lead author of a paper that was published in the journal Science.
“There may be a long-lasting impact that you can’t undo if your child gets measles,” he said. “I hope this study can impress upon people the danger measles poses.”
The researchers used what Mina called “an unconventional approach” to search for the long-lasting immune system effects. Previous work in monkeys suggested that monkeys with the disease lost white blood cells their bodies had trained to fight off other illnesses, leaving them more likely to be infected.
To test if a similar thing may occur in humans, the group mined historical data to find out the relationship between measles incidence(发病率) and deaths from other infectious diseases.
They turned to data from England and Wales—developed nations where disease levels are generally low, allowing a less-confused view of measles’ effects. Studying measles incidence and deaths from infectious disease both before and after the introduction of the measles vaccine in the U.K. in the 1960s, Mina and the team saw a sort of shadow effect, where deaths from a variety of non-measles infectious diseases closely tracked measles incidence. The more measles in a population, the more deaths from other illnesses in the 28-month period that followed.
“Really it didn’t matter what age group, what decade or what country,” said Mina. “They all showed consistent results… what we’re suggesting happens over the long term is that your immune system works fine, but it has forgotten what it previously learned.”
Some researchers who were not involved in the work questioned whether the reductions in deaths as measles cases declined may have had more to do with improving nutrition and smaller family size than with prolonged immune suppression.
Others thought the paper’s opinion of years-long suppression was seemingly reasonable but said they could not comment on the mathematical models the group used.
To know for certain what was behind the effect the group saw, Mina agreed, scientists would need to look at immune cells and observe their behavior. He said he would like to push the work in a more traditional direction: back into the laboratory.
1. Why did Mina call their research method “an unconventional approach”?A.Their research compared monkeys with humans. |
B.Their research was based on the historical data. |
C.They discovered a sort of shadow effect |
D.They only paid attention to developed nations. |
A.They warned people that measles can result in other infectious diseases |
B.They showed how dangerous measles is and the importance of vaccination. |
C.They carried out the research on measles in an unconventional approach. |
D.They found out the disease levels are generally low in developed nations. |
A.keep away | B.survive from | C.search for | D.turn down |
A.Measles has been the origin of other diseases and deaths. |
B.New research conducted into measles has been widely questioned. |
C.Damage caused by measles to the immune system could last several weeks. |
D.Study points to years-long immune system misfortunes from measles. |
4 . Do you think I’m insane?
This question came from Elon Musk near the very end of a long dinner we shared at a high-end seafood restaurant in Silicon Valley. I’d gotten to the restaurant first and settled down with a gin and tonic, knowing Musk would—as ever—be late. After about fifteen minutes, Musk showed up. Musk stands six foot one but he is absurdly broad-shouldered and sturdy. You’d figure he would use this frame to his advantage and perform an alpha-male strut (昂首阔步) when entering a room. Instead, he tends to be almost sheepish. His head tilted slightly down while walking, a quick handshake hello after reaching the table, and then butt in seat. From there, Musk needs a few minutes before he warms up and looks at ease.
Musk asked me to dinner for a negotiation of sorts. Eighteen months earlier, I’d informed him of my plans to write a book about him, and he’d informed me of his plans not to cooperate.
His rejection stung but sent me into dogged reporter mode. If I had to do this book without him, so be it. Plenty of people had left Musk’s companies, Tesla Motors and SpaceX, and would talk, and I already knew a lot of his friends. The interviews followed one after another, month after month, and two hundred or so people into the process, I heard from Musk once again. He called me at home and declared that things could go one of two ways: he could make my life very difficult or he could help with the project after all. He’d be willing to cooperate if he could read the book before it went to publication, and could add footnotes (脚注) throughout it. He would not meddle with my text, but he wanted the chance to set the record straight in spots that he deemed factually inaccurate. I understood where this was coming from. Musk wanted a measure of control over his life’s story. He’s also wired like a scientist and suffers mental anguish at the sight of a factual error. A mistake on a printed page would eat away at his soul—forever. While I could understand his perspective, I could not let him read the book, for professional, personal, and practical reasons. Musk has his version of the truth, and it’s not always the version of the truth that the rest of the world shares. He’s prone to lengthy answers to even the simplest of questions as well, and the thought of thirty-page footnotes seemed all too real. Still, we agreed to have dinner, chat all this out, and see where it left us.
1. Why did the author meet up with Elon Musk at the restaurant?A.Because the alpha male forced him into this appointment. |
B.Because his autobiography featured Musk’s legends. |
C.Because he relied on this interview for factual accuracy. |
D.Because the businessman was willing to help unconditionally. |
A.Musk’s rejection forced him to give up on interviewing anybody. |
B.Many of his former employees resigned because of his bossiness. |
C.Musk agreed to cooperate if he could read the book before publication. |
D.Musk has behaved in an unconventional way from time to time. |
A.Dominant and impolite. | B.Creative and outgoing. |
C.Shy and obsessive. | D.Caring and generous. |
1. How many foreign students are visiting in the speaker’s school now?
A.About 13. | B.About 20. | C.Over 30. |
A.To attract more foreign students. |
B.To exchange ideas about culture. |
C.To help foreign students enjoy their time. |
A.Before September 15th. |
B.In the last week of September. |
C.In the first week of December. |
A.In the library. | B.In the garden. | C.On the playground. |
1. What is the average height of Salt Lake City?
A.4327 feet above sea level. |
B.200 feet above sea level. |
C.110.4 feet above sea level. |
A.“Great Salt Lake”. |
B.“Great Salt Lake City”. |
C.“Crossroads of the West”. |
A.The sports game. |
B.The tourist industry. |
C.The construction of railroad. |
A.The ocean. | B.Rivers. | C.Mountains. |
Acupuncture, one of the most famous Chinese medical treatments, is increasingly well received among the world with solid evidence
10 . Experts hope an experimental drug can be as effective against the novel coronavirus in people as it has been on cells in a controlled lab environment.
The US drug, remdesivir(瑞德西韦), began clinical trials on patients in Wuhan, Hubei province, on Thursday. Other medications, including chloroquine, arbidol and darunavir have also recently been found capable of arresting viral growth in lab cells, but like remdesivir they require more clinical trials to confirm their safety and potency on humans.
The Phase III trials for remdesivir have been approved by China’s National Medical Products Administration and is conducted by the China-Japan Friendship Hospital in Beijing and the Chinese Academy of Medical Sciences on patients at the Wuhan Jinyintan Hospital.
A total of 761 patients will participate in two trials-one trial to assess the drug’s potency on 308 cases with mild or moderate infection, and the other on 453 severely infected patients, Cao Bin, head of the clinical trial and vice-president of the friendship hospital, said on Wednesday.
Cao said studies have shown remdesivir is effective in inhibiting the growth of the novel coronavirus in vitro(在生物体外), meaning the procedure was done on cells in a controlled environment outside of a living organism, typically in a petri dish or test tube.
But the drug has yet to show convincing clinical evidence that it can translate its positive in vitro results into actual human patients. Hence, it will require rigorous clinical testing, Cao said.
A 35-year-old patient from the United States infected with the virus was reported seeing noticeable improvement with no obvious side effects after taking the drug, according to the New England Journal of Medicine.
Gilead Sciences, the maker of remdesivir, said in a recent statement that it has been working with government agencies on the novel coronavirus response efforts.
However, the company stressed that remdesivir is an experimental medicine that has only been used in a handful of patients on compassionate grounds, “so we do not have an appropriately robust understanding of the effect of this drug to warrant broad use at this time”.
1. Why does the US drug, remdesivir, began clinical trials?A.To see how it takes effect. |
B.To replace the traditional medicine. |
C.To confirm their safety and potency on humans. |
D.To show whether remdesivir is effective in inhibiting the growth of the novel coronavirus in vitro. |
A.Chinese Hospital does The Phase III trials independently. |
B.Remdesivir can cure those who are infected with the novel coronavirus. |
C.After taking the drug, a 35-year-old patient was infected with the virus. |
D.Doctors had seen apparent success treating a 35-year-old patient infected with the virus. |
A.Negative. | B.Positive. | C.Critical. | D.Gloomy. |
A.A diary. | B.A guidebook. | C.A novel. | D.A magazine. |