1 . Chinese scientists have identified a new protein that restricts HIV infection, a discovery that could pave the way for the development of new drugs against the virus. The protein, P-selectin glycoprotein ligand 1 (PSGL-1), which exists in human cells, can inhibit (抑制) the process by which HIV reproduces, according to research published in the science journal Nature Microbiology this month.
However, the study also showed that PSGL-1 can be negatively affected by Vpu — an accessory (附属) protein of HIV — which can neutralize the ability of PSGL-1 to resist HIV. Further research is under way to develop a drug that can inhibit the HIV protein so that PSGL-1 can restrict HIV, according to Tan Xu, a researcher at Tsinghua University's School of Pharmaceutical Sciences, a leading author of the study.
Several other proteins in human cells that could resist HIV have been discovered over the past 10 years, but the virus can also evade (避开) them. PSGL-1 shows particular promise in that it can inhibit HIV in multiple ways — especially by blocking the infectiousness of virus offspring, Tan said.
“We are starting to research into small molecule (分子) compounds in the hope of finding one that can restore PSGL-1’s anti-HIV function. In this way, we can develop a very effective antiviral drug for people with HIV/AIDS,” he said. Tan said it will require at least three to five years for the research to reach the preclinical stage, and more time after that before a clinical trial is possible. The research was conducted by researchers at Tsinghua University in Beijing, Fudan University in Shanghai and George Mason University in the United States.
Existing treatment methods for people with HIV/AIDS, which mostly rely on a combination of different drugs, can prevent the disease from progressing but cannot cure it, and long-term use of drugs can result in drug resistance.
An estimated 37 million people in the world live with HIV, according to the Joint United Nations Programme on HIV/AIDS. The study provides new leads to developing antiviral drugs, Tsinghua University said in a statement.
1. What can we learn about PSGL-1 from the passage?| A．Both the protein PSGL-1 and the protein Vpu are HIV proteins. |
| B．PSGL-1 can restrict the function of the protein Vpu. |
| C．PSGL-1’s molecule compounds have been identified. |
| D．The protein PSGL-1 functions better than others in resisting HIV. |
| A．The existing treatment for AIDS are far from perfect. |
| B．It will be a decade before the antiviral drugs is put on the market. |
| C．American scientists played a leading role in the research. |
| D．HIV/AIDS will no longer be a deadly problem owing to the new discovery. |
| A．There is a long way to go before curing AIDS. |
| B．More people are faced with the threat of HIV. |
| C．Chinese scientists are leading the way in curing AIDS. |
| D．A new protein to resist HIV was confirmed by scientists. |
| A．A guidebook. | B．A fiction. | C．A magazine. | D．A brochure. |
Blood: Water Mission is founded by the Grammy Award-winning band, Jars of Clay.
The results of our efforts paint a new picture in these communities. There has been a remarkable improvement in the water situation and community health.
It’s a beautiful story. We invite you to be a small part of a larger, beautiful story.
| A．Clean water wells have been built. |
| B．Most children get the opportunity to go to school. |
| C．There is a vital link between HIV/AIDS and clean water. |
| D．Meanwhile, the 1,000 Wells Project has expanded along the way. |
| E．Blood: Water Mission has also created social effects in the United States. |
| F．Blood: Water Mission has developed a close friendship with these communities. |
| G．There are many projects providing much-needed assistance to African communities. |
3 . Mike Mushaw joined the national bone marrow registry (骨髓登记) three years ago by chance. Six months later, he got a call. The 21-year-old football player's bone marrow matched a patient in Virginia. Mushaw gave a second thought to the donation, because apart from some risks, he never knew whether his donation worked.
“Finally I said yes,” Mushaw told the journalist. “Once they took my blood, I thought, ‘All right, this is real. This is going to happen.’”
Mushaw didn't know it at the time, but his donation would go to a five-month-old girl named Eleanor who was sick with a rare disease diagnosed when she was only three months old. Days and weeks passing, her condition had become more dire.
“Eleanor was going to die without a bone marrow transplant,” her mother, Jessica, said. “The choices were to either get a transplant or die early. Luckily, Mushaw’s bone cured her.”
Mushaw didn't know any of this until months after his donation. About six months after the procedure, Eleanor's parents sent him an e-mail to thank him for his selfless love.
Their surprising connection was beginning. Mushaw kept checking on her progress. Eleanor focused her attention on him, too, by watching his football games on TV. In August, Mushaw invited her family to drive from Virginia to Connecticut to meet at one of his games. They had a good time together.
In January, Mushaw reunited with Eleanor, this time in Virginia, to celebrate her birthday. It will likely be first of many celebrations together. “As a parent, it feels really great to watch someone love your kid as much as you do,” Jessica says. “We were two complete strangers, and now we've become such a big part of each other's lives.”
1. Why did Mushaw hesitate at first?| A．He was a football player. | B．He would face some danger. |
| C．He knew it wouldn't work at all. | D．He didn't know whether his risks were worthy. |
| A．Serious. | B．Complicated. | C．Relieved. | D．Hopeful. |
| A．Kind but hesitant. | B．Active and confident. |
| C．Worried but energetic. | D．Selfless and considerate. |
| A．Why health matters. | B．Never make excuses. |
| C．How to be a good person. | D．Love brings people together. |
