1 . The first wave of a new class of anti-aging drugs have begun human testing. These drugs won't let you live longer but aim to treat specific illnesses by slowing a fundamental process of aging.
The drugs are called senolytics—they work by removing certain cells that accumulate as we age. Known as “senescent” cells, they can create low-level inflammation (炎症) that prevents normal systems of living cells repair and creates a poisonous environment for neighboring cells.
In June, San Francisco - based Unity Biotechnology reported initial results in patients with mild to severe osteoarthritis (关节炎) of the knee. Results from a larger clinical trial are expected in the second half of this year. The company is also developing similar drugs to treat age-related diseases of the eyes and lungs, among other conditions.
Senolytics are now in human tests, along with a number of other promising approaches targeting the biological processes that lie at the root of aging and various diseases.
A company called Alkahest injects patients with components found in young people's blood and says it hopes to stop conscious and functional decline in patients suffering from mild to moderate Alzheimer's disease. The company also has drugs for Parkinson's and dementia in human testing.
And in December, researchers at Drexel University College of Medicine even tried to see if a cream including the immune-suppressing drug could slow aging in human skin.
The tests reflect researchers' expanding efforts to learn if the many diseases associated with getting older- such as heart diseases, arthritis, cancer, and dementia- can be dealt with to delay their outbreak.
1. Why do the researchers develop the drugs?| A．To rid inflammation. | B．To lengthen people's life. |
| C．To treat age-related diseases. | D．To remove cancer cells. |
| A．Repairing. | B．Cycling. | C．Aging. | D．Dividing. |
| A．By listing data. | B．By providing details. |
| C．By making comparisons. | D．By analyzing causes. |
| A．A diary. | B．A guidebook. | C．A novel. | D．A magazine. |
2 . Skyscraper didn’t always mean a tall building. The earliest reference to the word dates back to 1788, when it was used to describe a really tall horse, according to The Oxford English Dictionary. By the 1790s, a Philadelphia doctor had used the term to describe the triangular sail at the very top of a ship.
After the Great Chicago Fire of 1871, the Home Insurance Company hired architect William Jenney to design a tall, fire-proof head office. Jenney was inspired to design the building’s steel framework (框架)after his wife placed a heavy book on a small birdcage and found that the cage supported the weight. Today, that revolutionary structure is widely considered to be the first skyscraper.
Since then, the competition to build the world’s tallest building has been as sharp as the top of the Empire State Building. In the late 1920s, Walter Chrysler and his architect arranged for the secret construction of a roof that added 125 feet of height to the new Chrysler Building, making it 1,046 feet tall. The plan allowed them to eclipse(使逊色)the 927-foot Bank of Manhattan Trust Building.
However, only 11 months after the Chrysler Building was ranked the world’s tallest, it was surpassed by a new neighbor — the Empire State Building. Yet when it opened in 1931, less than 25 percent of the building was occupied. New York jokers called it the “Empty State Building”.
The largest skyscraper in the world always seems to be under construction. Jeddah Tower in Saudi Arabia is the latest and it’s expected to stretch nearly one kilometer (3, 280 feet) into the sky.
1. What did the word “skyscraper” originally mean？| A．A triangular sail. | B．A high building. |
| C．A fire-proof head office. | D．An extremely tall horse. |
| A．given away | B．left behind | C．put off | D．taken up |
| A．It was ranked the world’s tallest. |
| B．Tourists were not allowed to visit it. |
| C．Its construction lasted eleven months. |
| D．Only a few people lived or worked in it. |
| A．In order of time. | B．In order of space. |
| C．By analyzing causes. | D．By giving definitions. |
3 . On July 24, 2020, Mike Stout launched his kayak（皮筏艇）just before 8：30 a.m. About 56 miles and 16.5 hours later, he landed on the sandy Michigan shore. It was his second time crossing Lake Michigan.
By chance, Stout said, he gave kayaking a try in 2016. Already in good physical condition, he considered kayaking a weekend escape. Then he was challenged by a client of his firm to think bigger. He did go big quickly. Weekend kayak trips were 40, 50 and 60 miles long over the next few months. Then his goal was to cross Lake Michigan that year. On August 3, Stout completed his first crossing of Lake Michigan in 15.5 hours. Since then, he’s finished countless long-distance trips on Minnesota rivers and lakes.
In heading back to Lake Michigan last summer, Stout thought he could become the first kayaker to make a round-trip crossing of the Great Lake. He felt capable. He’d put in 800 miles since March 1, 2020-when ice was still on the Minnesota River.
Stout wanted to do with manageable winds. Possibilities rose, only to become worse, the lake showing its mercurial nature. Stout realized a single crossing was his best hope. With local police informed of his plans and plenty of food aboard, Stout launched. His plan was to land on the Michigan shore 12.5 hours later. The lake thought otherwise. The winds and waves were working against him, too. Still, he was resolute. Finally he could hear waves crashing on shore.
“Never did I have a sense of doubt or fear or worry,” Stout said. Despite the constant, forceful wind, he said the crossing was easier than his others because of his experience. But no less meaningful. The stars, the chance to speak to the heavens, and the hope that his adventure would inspire others-all were fuel to finish.
1. What can we infer about Stout from paragraph 2?| A．He challenged his client. |
| B．He intended to escape real life. |
| C．He was organized and determined. |
| D．He set a goal bigger than his capability. |
| A．His physical state. | B．The weather condition. |
| C．The freezing water. | D．Warning from local police. |
| A．Changeable. | B．Merciful. | C．Perfect. | D．Balanced. |
| A．Weather. | B．Adventure. | C．Geography. | D．Entertainment. |
4 . If a president and a philosopher owed their success to the same secret, would you try to follow it too? What if the secret was something you already knew how to do? In fact, you probably do it every day. Here's what Friedrich Nietzsche wrote: “It is only ideas gained from walking that have any worth”. Thomas Jefferson: “Walking is the best possible exercise. Accustom yourself to walking very far.”
Are you still sitting there reading this? Get walking! It is not just the two great minds who made a case for it as a main creativity booster（推动）. Researchers have traced numerous connections between walking and novel ideas. A Standford University study found that participants were 81% more creative when walking as opposed to sitting. According to the study, walking outside—versus on a treadmill（跑步机）—produces the most novel and highest-quality ideas in participants who walked and then sat down to do creative work.
The movement aspect of walking is obviously key. You've probably heard the phrase “exercise your creativity”, which refers to the brain as muscle. Our creative thinking is triggered by physical movement, which is exactly why walking—with your dog, a friend or alone—feeds creative thinking.
But the scenery is almost as important as the sweat. A survey reveals that Americans spend 87% of their time indoors. Being inside, you're more likely to have less energy. Without energy, you can't wonder or create. Interrupting your routine with a walk can be a catalyst（催化剂）for gaining fresh insights into problems or projects. Just by going outside，you are stepping out of your comfort zone which is necessary if you want to open your mind to new possibilities. You can walk through a tree-filled neighborhood or a park and observe people wandering or birds singing.
So instead of setting a fitness goal, why not set a creative goal that starts with walking? Engage more closely with your surroundings. Walk just for exercise. Walk for wonder.
1. Why are the two great minds mentioned in Paragraph 1?| A．To suggest the way to exercise | B．To show the benefits of walking. |
| C．To give the definition of success | D．To stress the importance of creativity |
| A．Motivated. | B．Blocked. | C．Controlled. | D．Changed. |
| A．Americans spend most of their time enjoying it. |
| B．One can't wonder or create without it. |
| C．It can build a comfort zone for people. |
| D．It will expose people to new chances. |
| A．Scenery inspires new ideas. | B．Your creativity lies in sweat. |
| C．Exercise feeds creative thinking. | D．Your brain is made for walking. |
5 . The Arctic's permafrost is inciting— and fast. That's bad news, because these frozen soils store billions of tons of carbon, just waiting to be released. So is there a way to save the permafrost? One team of researchers thinks it may have found a possible solution: big animals, herbivores - animals that eat only plants.
Back in 1996 researchers started an experiment called Pleistocene Park. They fenced in about eight square miles of land in northeast Siberia. Then they introduced different types of herbivores: reindeer, horses, bison, sheep and other large creatures.
Since then, scientists have studied these animals' effects on the ecosystem. One outcome is that these large herbivores help keep the ground very cold — cooler than it would otherwise be.
“The snow in winter is important for soil temperature, because it acts as an insulating layer. So the air in winter, at the high latitudes, is much colder than the soil." Philipp Porada, a vegetation ecologist at the University of Hamburg. "So the idea of this experiment was to introduce large herbivores — and to quantify their effects on soil temperature to see if they can actually protect permafrost soils against melting. And this works because of the animals' trampling (践踏), and this leads to less insulation of the soil against cold air temperatures and results in a cooling effect.”
Freezing air reaches the soil more easily. Porada and his colleagues realized the significance of this effect, so they pulled data from Pleistocene Park and Sweden to model what effect herbivores could have on permafrost if they lived in large numbers in the Arctic.
They found that even in a worst-case situation, some four degrees Celsius of global wanning: “These herbivores in the model reduce soil temperature substantially, by 1.7 degrees on average. And this leads to a preservation of around 80 percent of the original — today's permafrost area. Without the herbivore effect in the model, only 50 percent of the permafrost area would remain by the year 2100. So we can say the effect of the herbivores in the model leads to a substantial preservation of permafrost soil."
1. Why is the Pleistocene Park Experiment mentioned?| A．To provide the past research data. |
| B．To share soil preservation experience. |
| C．To introduce a way to save permafrost. |
| D．To prove animals' effect on soil temperature. |
| A．Covering. | B．Blocking. |
| C．Storing. | D．Freezing. |
| A．Cooling the ground. | B．Heating the soil |
| C．Damaging the ground. | D．Softening the soil. |
| A．Permafrost Is Disappearing | B．Preservation of Permafrost |
| C．An Experiment on Herbivores | D．Herbivores Help Save Permafrost |
6 . Carbon is a chemical element which is present in organic compounds that make us organisms, plants as well as fossil. It is a vital component of the greenhouse gas CO2, the highest percentage of the global warming gas in the atmosphere.
These Green House Gases (GIIGs) along with other factors are responsible for the most discussed issues affecting the planet, climate change. Climate change has and still releases a huge set of environmental disasters which are fueling the difficulty of survival on the planet. In order to eliminate, reduce and adapt to these risks of survival, individuals, organizations, and countries will have to adopt carbon neutrality measures. The main aim of carbon neutrality is to achieve a net-zero emission either by balancing the emission or absorbing of carbon or quit the production of carbon. However, to really understand carbon neutrality, the carbon cycle should be first understood
The carbon cycle is the transfer of carbon through different media. Carbon has the ability to move in different media in different forms at different rates and tines. These different factors (rate, time, and media) are the phenomena underlying carbon neutrality. For instance, carbon released into the atmosphere by the rapid burning of fossil fills back as rain in the form of carbonate (碳酸盐) and is absorbed by the reservoirs (oceans, surface water, and the earth surface). Even though the exchange of carbon between some of these reservoirs takes a long time, some over 100 years, carbon was absorbed until now. The main problem existing today is that the emissions of CO2 are too high to be offset by the reservoirs, thereby leaving the offsetting task to us.
The European Union (EU) is taking all measures it can to offset carbon through Emission trading system which helps industries to manage their carbon footprints. Similarly, China, which is responsible for 25% of the world's CO2 emissions due to its economic and industrial structure is currently decreasing its energy consumption/GDP and CO2 emission/GDP, while increasing is forest cover and air quality through its 14th Five-Year Plan (2021-2025) carbon neutrality actions.
1. What does the underlined word "fueling" in Paragraph 2 most probably mean?| A．Experiencing. | B．Overcoming. | C．Increasing. | D．Ending. |
| A．By giving an example. |
| B．By comparing media. |
| C．By analyzing data. |
| D．By describing a task. |
| A．GHGs take the whole blame for the climate change. |
| B．Carbon exchange takes little time. |
| C．The contribution of the EU is not obvious. |
| D．China las a clear goal in low-carbon efforts. |
| A．Politics. | B．Environment. | C．Commercial. | D．Lifestyle. |
7 . A shocking news report has revealed that more than one in five species of maple trees faces extinction, warning that 75% of the threatened species are “geographically restricted” in their native regions.
The trees are experiencing a vast decline in habitat, due to urban development, wood harvesting and agricultural expansion. Time is running out for the world's biodiversity. Every recent survey of plants and animals in the wild points to this. This is happening nearly everywhere rarer maples exist. And because of climate change, the narrow habitats that support species at the edges of dry places and at the tops of mountains are quickly disappearing.
The trees can be found in subtropical and tropical regions, as far south as Indonesia. The only species found in the UK, the field maple is not under threat. Not only are the trees a popular attractive feature in parks and public spaces, but they are a key part of the natural ecosystem in woodlands, as well as being an important wood crop in several countries. Although the sugar maple in North America, which produces maple juice, is not endangered, two of the closest relatives to the species are endangered.
The report notes that conserving at-risk species in their natural habitat is the best conservation tactic. But collections in botanical gardens and seed banks-called "ex situ collections" can act as insurance policies against extinction. There are currently 14 species of maple, including four that are critically endangered, which are absent from these types of collections.
One species in Mexico, the Acer binzayedii, is in “desperate need of conservation"”despite only being discovered in 2017. “It is at risk from climate change in its cloud forest habitat and threatened by logging and forest fires while it is also absent from 'ex situ collections',” the report adds. The report recommends developing conservation plans, monitoring species currently not at risk to ensure populations are maintained, and adding those missing maple species to seed banks.
1. What is paragraph 2 mainly about?| A．Action to protect maple trees. | B．The dangerous situation of maple trees. |
| C．Various maple trees' habitats in the world. | D．The conditions for diversity in maple trees. |
| A．They cannot produce juice. | B．They are found in America. |
| C．They are not at risk of extinction. | D．They have two endangered relatives. |
| A．Topic. | B．Approach. | C．Result. | D．Conclusion. |
| A．To offer a proposal. | B．To recommend a product. |
| C．To introduce maple species. | D．To warn people of disasters. |
8 . In recent years, Ethiopia has become a regional leader in solid waste management. Last year, the country transformed the landfill (垃圾填埋场) in Addis Ababa into a new waste-to-energy plant, the first such project on the continent. The plant incinerates up to 1, 400 tonnes of waste every day, about 80 percent of the city's rubbish, supplying the capital with 25 percent of its household electricity needs.
However, despite these important steps, challenges remain in Ethiopia. Although the country has permitted the Basel, Stockholm and Rotterdam conventions, laws and policies for environmentally sound management of hazardous (有害的) wastes are still not effective in pre- venting littering waste illegally.
To help Ethiopia meet these challenges, the Chemicals and Waste Management Program is supporting the country with a three-year project to enhance its capacity for sound management of hazardous wastes.
In the initial stages, a project management unit will be formed, made up of many representatives from government departments and private organizations. This unit will be responsible for reviewing and assessing Ethiopia's current legal system, which, despite numerous advances in recent years, does not specifically target the recycling of hazardous waste. Once legal gaps are identified, the project will seek to update existing policies and strategies.
Many people in Ethiopia are not aware of the possible effect of environmental damage and the need to report such crimes to the police. To resolve this pressing issue, Ethiopia will be conducting a series of capacity-building activities, including creating awareness-raising programs, training trainers and providing equipment.
Ethiopia will also work to establish a national mechanism for chemicals and waste management by engaging government departments and civil society groups. Authorities will also make budgetary provisions (预算拨款) in national, regional and institutional planning to ensure funding for these activities is sustainable even after the project's completion.
1. Which can replace the underlined word “incinerates” in paragraph 1?| A．Produces. | B．Burns. | C．Gathers. | D．Absorbs. |
| A．The relevant laws are not sound. | B．The shortage of workers is severe. |
| C．The pollution level is too high. | D．The funds are not sufficient. |
| A．Restrict their environmental movement. | B．Call on them to start some programs. |
| C．Reward them with budgetary provisions. | D．Raise their environmental awareness. |
| A．Ethiopia is facing serious environmental problems. |
| B．Ethiopia has achieved success in waste management. |
| C．Ethiopia is putting efforts into waste management. |
| D．Ethiopia has reduced environmental pollution levels. |
9 . I stood behind the curtain, my hands shaking. As I listened to the crowd laugh at the host's jokes, I thought about why I believed I could do that. Two months earlier, I had signed up for improv（即兴表演）classes at a local theater, along with four other graduate students.
When I first heard about the improv classes, I was torn. I feared getting on stage and performing in front of strangers. However, I knew I wanted to work as a science communicator after finishing my Ph.D., so it seemed like a perfect opportunity to improve my communication ability and gain confidence thinking on my feet.
During our first class, we learned the key concept of improv: “yes, and”. If someone says that rhinos are librarians, for example, then rhinos are librarians. We don't question the logic; we say “yes” and continue with the scene as if nothing is wrong. To do this effectively, we have to avoid second-guessing ourselves. Sometimes scenes go in unexpected directions. The best improv happens when performers stay open to different possibilities. Over time, I started to enjoy our classes. I also became better at listening and communicating clearly in the moment.
That training came in handy 6 months ago, when I was giving a seminar about my science research. An audience member surprised me with a question that didn't grow out of the information I had presented. Instead of getting perplexed, I used that approach, and it helped me find an appropriate answer.
Last year, I used that approach when dealing with confusing data. Instead of getting discouraged, I kept exploring the data and ended up identifying a new type of cell — one that wasn't behaving as expected. If I hadn't stayed open to the possibility that the results were real, I would have missed out on the most exciting finding of my Ph.D. program so far.
1. The author expected that the improv classes could help him ________.| A．gain better skills in communicating |
| B．rid his fear of appearing on the stage |
| C．recover from a mental illness |
| D．learn how to think independently |
| A．Pretending to be clever. |
| B．Understanding different scenes. |
| C．Accepting unexpected possibilities. |
| D．Asking others some questions. |
| A．Amused. | B．Confused. |
| C．Surprised. | D．Disappointed. |
| A．He failed in exploring the new cell. |
| B．He got stuck after finding unexpected data. |
| C．Science research made him more confident. |
| D．The improve skill helped him a lot in his Ph.D. studies. |
10 . They say, “Online retailers (零售商) try to show you things that you wouldn’t have discovered otherwise. But we don’t think it compares to the experience of walking into a store and seeing things you wouldn’t have seen otherwise.”
That’s hardly an old-fashioned view. One of the misunderstandings in retail is that because younger customers are comfortable with digital technologies, they’re less interested in shopping in person. In fact, researchers have found that both millennials (千禧一代) and the generation born after 1995 prefer brick-and-mortar shopping to buying online.
Now in the pandemic age, retailers are working on making ordering online and picking up at the store a seamless (无缝衔接的) process. And that could be just the start. Other mixed models will appear, especially as retailers get rid of delays from the system, says Kirthi Kalyanam, executive director of the Retail Management Institute at Santa Clara University in California. Amazon, which already provides free two-day delivery to prime members, now offers one-day delivery nationwide for a fee and same-day delivery on select items in several cities. Its Amazon Fresh grocery service lets shoppers choose delivery within two to three hours.
Stores will increasingly become places to show products rather than to store inventory (存货), says Mr. Kalyanam. Online retailers will re-create their online image in a real space: Think Apple stores or Lululemon. And consumers will have multiple ways to buy their goods. Stores might not even carry inventory, but promise to deliver your purchase from a nearby warehouse in a half-hour.
1. What is the speakers’ attitude to buying online in Paragraph 1？| A．Negative. | B．Positive. |
| C．Indifferent. | D．Unknown. |
| A．Imaginative. | B．Physical. |
| C．Virtual. | D．False. |
| A．Amazon never connects the sales to the delivery. |
| B．Delivery service of goods online is being improved. |
| C．All retailers are considering picking up at the store. |
| D．Retailers can’t remove the delays from the delivery system. |
| A．Amazon offers one-day delivery nationwide for free. |
| B．Younger customers are less interested in shopping in person. |
| C．Instead of storing inventory, stores will become places to show products. |
| D．Online retailers don't show the things that customers haven't discovered. |
