Ali heard her sing when she played the piano. And he saw his grandmother diagnosed with disability was singing together with him. He was absolutely shocked. The disease took her legs away as long as he could remember. His grandmother even danced to the music, totally attracted by the piece of music. Out of curiosity, he asked his grandmother what had happened on earth. She giggled and began her story.
Oh, dear, let me share a story with you. When your grandfather went fishing on the boat, I was so afraid of losing him, and I was so afraid that he would never come back. The only way I could stay calm was to dance. I pretended to feel good. However, from my bottom of my heart, I experienced the pain of not knowing whether my love would come back safely. Every day I went home, excited but frightened to read his letters. He always ended his letters with “I love you with my life and God blesses you good health.” And then one day came a letter only with three sentences, “I have lost my arms. I give you back your freedom and you deserve a better one.” Thinking for a long time, I made a decision that I would pretend I was disabled too. I bought a stick and a wheelchair myself. I told my friends and families as well as him that I got a car accident, losing both of my legs, unable to dance anymore. Then I went to see your grandfather. I told him “you are the better one I should deserve; and we are the same, without feeling sorry for ourselves.” I leaned forward and showed him a wedding dress. “Now show me you are still a man,” I said, “I won’t ask again.” He finally smiled and managed it on me, walking towards me and giving a big hug.
Looking at grandmother for a while, Ali was deeply inspired by her. “You are an angel and I will love you forever.” Ali murmured quietly.
注意：1．开头已给出；
2．所写词数应为150左右。
Paragraph 1：
Grandmother smiled at Ali and asked him to make a promise not to tell his grandpa till the end of her life.
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Paragraph 2：
A few years went by and six months after grandmother’s funeral, Ali found grandpa sitting in grandma’s usual chair by accident and sobbing sadly.
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2 . Researchers from ETH Zurich, the University of Zurich, and the University Hospital Zurich have made a significant breakthrough in the field of precision medicine. They have developed a machine learning approach known as CellOT that can predict how individual cells react to specific treatments. This development promises more accurate diagnoses and therapeutics, particularly in the fight against cancer.
Precision medicine, which aims to find the most effective drug combination and dosage (剂量) based on individual patient characteristics, has been a critical goal in the battle against cancer. Central to this is understanding how individual cells respond to treatment, a challenge that the research team from Zurich has tackled head-on with their innovative method.
CellOT is a groundbreaking approach that identifies the distinct reactions individual cells within a larger population can have to a drug. The average response of a cell population often does not capture the full complexity of how certain tumor cells survive or develop resistance to drugs. CellOT addresses this by predicting the effects of perturbations (扰动) on cells, paving the way for more effective and personalized cancer treatments.
Perturbations are changes caused by chemical, physical, or genetic influences, such as the effects of drugs on cancer cells. By understanding which cells respond to a drug and identifying the traits of resistant cells, researchers can develop new treatment strategies that prevent cell growth or cause pathogenic (致病的) cells to die.
For CellOT, the researchers use novel machine learning algorithms and train these with both data from unperturbed cells and data from cells that changed after a perturbation response. In the process, the algorithm learns how cellular perturbation reactions arise, how they progress, and the likely phenotypes (显性类型) of altered cell states.
The study, published in Nature Methods, shows that CellOT is not just effective for cancer cells. It can also be used on other pathogenic cells involved in autoimmune diseases like lupus erythematosus (红斑狼疮), indicating its potential in advancing treatments for various diseases.
A key innovation of CellOT is its predictive ability. By evaluating existing cell measurement data, and thus expanding the knowledge of cellular perturbation reactions, CellOT can predict how individual cells will respond to perturbations that have not been measured in the laboratory. This capability opens up new avenues for targeted and personalized treatments.
While CellOT holds immense promise, comprehensive clinical trials are still required before the approach can be used in a hospital setting. Nevertheless, the development of this method marks a significant step towards a more nuanced (细腻的) understanding of individual cell responses to drugs. It fuels the hope for more effective cancer treatments and advances in precision medicine.
1. The underlined word “this” in Paragraph 3 refers to _______.| A．various responses of a cell population to drugs |
| B．the average reaction of a cell population to drugs |
| C．the resistance from a group of cancer cells to drugs |
| D．the survival of a population of cancer cells to drugs |
| A．has proved efficient in some Zurich hospitals |
| B．can cause perturbations inside a human body |
| C．may bring about better treatments for various diseases |
| D．focuses on monitoring the development of cancer cells |
| A．The limitations of CellOT. |
| B．Suggestions for CellOT improvement. |
| C．An explanation of further research. |
| D．Future implications of CellOT. |
| A．A Groundbreaking Medicine for Cancer |
| B．Precision Medicine is Around the Corner |
| C．How Machine Learning Helps Zurich Doctors |
| D．CellOT: Advancing Precision Cancer Treatment |
3 . Nancy, a 7-year old girl helped her mother wash the windows of their house after school to get a reward promised by her mother, a purple
The next day, Nancy asked if she could
The following day, while looking up another
So the next week, Nancy’s family loaded up their car and took all the dolls to the playroom at the
Nancy’s parents took a lot of memorable pictures to cherish the wonderful moments. Nancy thanked her parent and told them she would never forget what she got on this special day and that she had a lot of
| A．ball | B．doll | C．bear | D．dog |
| A．check | B．inform | C．refuse | D．stop |
| A．stated | B．drew | C．clicked | D．described |
| A．suggestions | B．wonders | C．worries | D．problems |
| A．before | B．ago | C．earlier | D．later |
| A．hand | B．cart | C．room | D．drawer |
| A．ongoing | B．failing | C．strange | D．online |
| A．on display | B．for sale | C．on sale | D．on the way |
| A．cancel | B．consider | C．take | D．sell |
| A．rewards | B．gifts | C．packages | D．toys |
| A．advised | B．forbade | C．disliked | D．minded |
| A．deserted | B．local | C．nearby | D．remote |
| A．pleased | B．excited | C．depressed | D．frightened |
| A．put up | B．picked up | C．put away | D．opened up |
| A．rest | B．fun | C．homework | D．pressure |
| A．Make a phone call. | B．Go on the Internet. | C．Take a train trip. |
5 . Scientists have already applied robots like Roomba to work in the agriculture (农业). A Roomba works because it has wheels that function well on flat ground. However, fields are full of rough and rocky environments, which means it is difficult for robots to work in the fields. Luckily, scientists thought of centipedes (蜈蚣). With tens to hundreds of legs, they can move on any places without stopping. If they stop moving their body parts and feet, they basically stop moving instantly.
A team led by Chong developed a theory that proposes that adding leg pairs to the robot increases its ability to move firmly over challenging environments.
To test this, Juntao conducted a series of experiments where he and Daniel Soto built models to simulate (模拟) different natural environments. He then tested the robot by increasing its number of legs by two each time, starting with six and finally increasing to 16. As the leg count increased, the robot could more easily move across the surfaces, even without sensors. Finally, they tested the robot outdoors on real environments, where it was able to move in a variety of environments.
The researchers are applying their discoveries to farming. Goldman has co-founded a company that wants to use these robots to weed (除草) farmland where weedkillers are ineffective. “It’s truly impressive to see the multilegged robot easily moves on both lab-based and outdoor environments,” Juntao said. “Now we are deciding the most suitable number of legs to achieve motion. In the future, we hope to apply them for space exploration, and even search and rescue.”
1. What can we learn about Roomba?| A．It can move on any places without stopping. |
| B．It can not work well in the rough farmlands. |
| C．It was newly invented and still in its early age. |
| D．It was inspired when scientists saw centipedes |
| A．Unpractical. | B．Amusing. | C．Ineffective. | D．Promising. |
| A．It will reach consumers soon. | B．It will increase farm production. |
| C．It will be used in many other fields. | D．It will take the place of weedkillers. |
| A．Centipedes Inspire Multilegged Robots’ Invention |
| B．Scientists Get a Huge Step in Studying Centipedes |
| C．Scientists Solved Challenges in Robots’ Creation |
| D．Multilegged Robots Brought Benefits to Farming |
Friends play an important part in everyone’s life. Friendship usually
Those friends that you make as a student can usually last long. Friends influence your development, maturity and sense of
Yet these days, the modern tools that keep us connected are eating away at the meaning of friendship. We may be able to make many friends online, but these
True friends are difficult
7 . Here is a list of four upcoming book festivals. Registration is either just opening or hasn’t quite opened up yet and not all of the festivals have finalized their attendee lists, but it’s never too early to plan which ones you’d like to attend!
THE IMAGINARIUM BOOK FESTIVAL Washington D. C.
The Imaginarium Book Festival celebrates all things fantasy. science fiction, paranormal (超自然的) and fantastical. In addition to a lecture where authors will answer your questions, you’ll get to meet and acquire signed books from your favorite authors.
BOOK BONANZA Grapevine, Texas
Book Bonanza, started by Colleen Hoover and her sisters, is a celebration of books. It attracts a huge list of incredible author attendees. What makes Book Bonanza stand out is its charitable focus. All the incomes are donated to charitable causes.
NORTH TEXAS TEEN BOOK FESTIVAL Irving, Texas
The North Texas Teen Book Festival brings authors and readers together to celebrate teen literature and inspire lifelong readers. They have not announced their author attendees yet, since the deadline for submission of the authors has not yet arrived.
SAVANNAH BOOK FESTIVAL Savannah, Georgia
The Savannah Book Festival hosts national, regional, and local authors for author presentations and book signings at seven places across three historic squares in downtown Savannah. But the author lineup has not been shown yet.
1. What can people do at the Imaginarium Book Festival?| A．Buy books signed by hosts. | B．Give a lecture about writing novels. |
| C．Watch science fiction movies. | D．Ask authors some questions. |
| A．It’s celebrated by many directors | B．It invites few famous authors. |
| C．It focuses on charity work. | D．It was founded by two sisters. |
| A．They haven’t published the list of authors. | B．They haven’t decided on the place yet. |
| C．They provide the book signing service | D．They celebrate the youth literature. |
1. How old is the man?
| A．17. | B．27. | C．30. |
| A．Brother and sister. |
| B．Photographer and model. |
| C．Charity worker and client. |
| A．Some money. | B．A car. | C．A photograph. |
1. In which country do people note at beer?
| A．Brazil. | B．Japan. | C．India. |
| A．Wearing slippers in the bathroom. |
| B．Wearing purple clothes to a funeral. |
| C．Giving an umbrella to a friend as a gift. |
| A．A travel to a new country. |
| B．Taboos in different countries. |
| C．Social behavior that is allowed. |
10 . Like reading? Interested in Chinese classical novels? Have a look at the following four books which are we known to most Chinese as Four Masterpieces.
The Water Margin
The Water Margin, also known as All Men Are Brothers in Pearl Buck’s translation, Shui Hu Zhuan in Chinese, is along chapter novel with the Song Jiang Uprising in the late Northern Song Dynasty as the main background and type of heroic legend. It is an immortal (不朽的) novel and has inspired many storytellers. The author of the novel is generally regarded as Shi Nai’an (1296~1371).
Romance of the Three Kingdoms
Romance of the Three Kingdoms is the first full-length historical romance novel in China. Its author is Luo Guan zhong (about 1330~1400), a famous novelist in the late Yuan Dynasty and the early Ming Dynasty. Characters such as Liu Bei, Cao Cao, Guan Yu, Zhang Fei and Zhuge Liang have become household names among the Chinese.
Journey to the West
Journey to the West is the first romantic chapter novel about gods and devils in ancient China. There are 100 copies of Journey to the Westin the existing Ming Publications without the author’s signature. Wu Yuxuan, a scholar of the Qing Dynasty, first proposed that the author of Journey to the West was Wu Cheng’en (1500~1582) of the Ming Dynasty.
The Dream of the Red Chamber
The Dream of the Red Chamber, also called The Story of the Stone, is said to be the greatest masterpiece of Chinese fiction. It is generally believed to be written by Cao Xueqin (about 1715~1763), a writer of the Qing Dynasty. With hundreds of persons and their stories, the story is very complex but also very interesting for its encyclopedic character(百科全书式的人物).
1. Which book should people read if they want to know something about the character Song Jiang?| A．The Water Margin. | B．Romance of the Three Kingdoms. |
| C．Journey to the West. | D．The Dream of the Red Chamber. |
| A．Shi Nai’an. | B．Luo Guanzhong. | C．Wu Cheng’en. | D．Cao Xueqin. |
| A．Health. | B．Literature. | C．Sports. | D．Science. |
