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阅读理解-阅读单选(约510词) | 较难(0.4) |
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文章大意:本文是一篇说明文。文章介绍了光污染的问题及其对人类和自然界的影响。人类通过设计照明来改变夜晚的黑暗状态,导致了光污染,影响了包括人类在内的许多生命形式已经适应的光线水平和光节律,改变了很多动物的行为和生物节律,甚至让人类忘记了自己在宇宙中存在的真实尺度。

1 . If humans were truly at home under the light of the moon and stars, we would go in darkness happily, the midnight world as visible to us as it is to the vast number of nocturnal (夜间活动的) species on this planet. Instead, we are diurnal creatures, with eyes adapted to living in the sun’s light. This is a basic evolutionary fact, even though most of us don’t think of ourselves as diurnal beings. Yet it’s the only way to explain what we’ve done to the night: We’ve engineered it to receive us by filling it with light.

The benefits of this kind of engineering come with consequence called light pollution whose effects scientists are only now beginning to study. Light pollution is largely the result of bad lighting design, which allows artificial light to shine outward and upward into the sky. Ill-designed lighting washes out the darkness of night and completely changes the light levels and light rhythms to which many forms of life, including ourselves, have adapted. Wherever human light spills into the natural world, some aspect of life is affected.

In most cities the sky looks as though it has been emptied of stars, leaving behind a vacant haze (霾) that mirrors our fear of the dark. We’ve grown so used to this orange haze that the original glory of an unlit night—dark enough for the planet Venus to throw shadow on Earth—is wholly beyond our experience, beyond memory almost.

We’ve lit up the night as if it were an unoccupied country, when nothing could be further from the truth. Among mammals alone, the number of nocturnal species is astonishing. Light is a powerful biological force, and on many species it acts as a magnet. The effect is so powerful that scientists speak of songbirds and seabirds being “captured” by searchlights on land or by the light from gas flares on marine oil platforms. Migrating at night, birds tend to collide with brightly lit tall buildings.

Frogs living near brightly lit highways suffer nocturnal light levels that are as much as a million times brighter than normal, throwing nearly every aspect of their behavior out of joint, including their nighttime breeding choruses. Humans are no less trapped by light pollution than the frogs. Like most other creatures, we do need darkness. Darkness is as essential to our biological welfare, to our internal clockwork, as light itself.

Living in a glare of our making, we have cut ourselves off from our evolutionary and cultural heritage—the light of the stars and the rhythms of day and night. In a very real sense light pollution causes us to lose sight of our true place in the universe, to forget the scale of our being, which is best measured against the dimensions of a deep night with the Milky Way—the edge of our galaxy—arching overhead.

1. According to the passage, human being ________.
A.are used to living in the daylightB.prefer to live in the darkness
C.were curious about the midnight worldD.had to stay at home with the light of the moon
2. The writer mentions birds and frogs to ________.
A.show how light pollution affects animals
B.provide examples of animal protection
C.compare the living habits of both species
D.explain why the number of certain species has declined
3. It is implied in the passage that ________.
A.human beings are curious about the outer space
B.human beings should reflect on their position in the universe
C.light pollution does harm to the eyesight of animals
D.light pollution has destroyed some of the world heritages
4. What might be the best title for the passage?
A.The Magic LightB.The Orange Haze
C.The Disappearing NightD.The Rhythms of Nature
阅读理解-七选五(约260词) | 较难(0.4) |
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文章大意:这是一篇说明文。文章主要讨论了人类提高生活水平与环境污染之间的关系。

2 . Humankind has tried to improve its standard of living since the very beginning of civilization (文明). Back then, and today, providing food was the basic task for a person.     1     People feel the need for not only some primary things, such as bread and shelters, but also for various facilities and luxuries. Providing humanity (人类) with these things is connected to the use of natural resources, which requires energy. In turn, the common sources of energy we use today cause pollution, so economic growth is almost inevitably connected with environmental damage.

    2     The first of these is the fact that in order to produce more goods and products, at a faster rate, the construction of large industrial plants is required. These plants produce a lot of waste, which may cause negative long-term health effects to nearby populations of animals, or people.

The traditional energy sources, which are commonly used nowadays, are considered to be the greatest polluters to the environment. There also exist so-called eco-friendly sources of energy.     3     Of course, during this time people have to make some sacrifices to support these undertakings (企业) .

In order to produce practical energy, a transformation of the natural site is often inevitable (不可避免的).     4     Application of wind energy would block airflow’s natural speed. Consequently, the pressure balance that is brought about by this current will be affected, and it is important to remember that the environment and weather conditions are directly affected by atmospheric pressure.     5     This is the embarrassment mankind has to deal with. A good balance between economic development and sustainability is forever what humankind has to keep in mind

A.There are certain aspects of economic growth which affect the environment.
B.Clean energy has always been on the priority list for a better environment.
C.For these reasons, bringing about economic growth without any resulting environmental damage is impossible.
D.However, nowadays the range of required goods has expanded significantly.
E.So humankind began to make exploration to satisfy themselves economically and mentally.
F.They are sometimes preferred but replacing the traditional sources with them also requires time.
G.This is expensive and, has harmful effects on the environment.
2024-05-31更新 | 78次组卷 | 1卷引用:北京师范大学附属实验中学2023-2024学年高一下学期期中英语试题
完形填空(约250词) | 较难(0.4) |
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文章大意:本文是一篇记叙文。文章讲述了作者在埃塞俄比亚露营期间,一个苏尔马族男孩请求拍照的故事。尽管作者疲惫不堪,但男孩的坚持和渴望让他决定帮助男孩拍照。在多次尝试失败后,作者放弃并试图安慰男孩,但男孩的真诚和喜悦让他意外捕捉到了更美好的瞬间。这次经历让作者意识到,有时候放下自己的预设,才能发现更真实的情感和价值。

3 . See Me

The sun prepared to rest for the evening. Saying goodbye to the clan (家族), I headed back to camp. I looked forward to setting my _______ aside for an evening to reflect on my time in Ethiopia.

“Photo, photo”, a voice behind me called. A young Surma boy followed closely at my heels as I breathed a tired sigh. Over the past four days, many in the camp had wanted their photograph _______. I had no energy left after this long day, but the boy kept appealing, “Photo, photo.” He managed to catch my gaze. With eyes full of _______, he asked me once more: “photo?”

As I looked at him, an idea flashed before me. I knelt in the cornfield and instructed the boy how to _______ . Suddenly, he became shy, losing his _______. No matter how I instructed him, I couldn’t capture the shot. Frustrated, I _______. I looked at the boy, who seemed _______.

In an effort to cheer him, I said, “You were great.” Others from his clan gathered around, cheering and clapping. The boy’s face broke into a smile. I intuitively took shots of the moment. That photograph turned out to be better than the arrangement I’d imagined because it was _______.

Reflecting on my experience, I realized I had been caught up in my own ideas and wants. When I agreed to take the shot, I was looking for a particular end _______ for myself. But all the boy had really wanted was to be __________. That was the moment that needed to be captured.

1.
A.cameraB.walletC.luggageD.plan
2.
A.printedB.takenC.framedD.developed
3.
A.doubtB.joyC.hopeD.despair
4.
A.poseB.moveC.operateD.stand
5.
A.patienceB.enthusiasmC.temperD.control
6.
A.gave upB.looked upC.spoke upD.cheered up
7.
A.angryB.amusedC.shockedD.upset
8.
A.personalB.naturalC.gracefulD.skillful
9.
A.requestB.reminderC.resultD.review
10.
A.admiredB.heardC.understoodD.seen
2024-05-15更新 | 65次组卷 | 1卷引用:北京市中国人民大学附属中学2023-2024学年高一下学期期中练习英语试题
阅读理解-阅读单选(约540词) | 较难(0.4) |
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文章大意:本文是一篇议论文。文章主要讨论了对话标签在小说创作中的应用。作者认为,尽管在创作时应该鼓励使用强有力的动词,但在对话标签中应避免使用过于创意的词汇,如“尖叫”、“低语”等,因为这些标签可能掩盖对话本身的光芒。对话应该是故事中的“钻石”,通过角色的语气、动作等自然表达情感,而不是通过对话标签。

4 . During a judging period for a recent short story contest, I started thinking a lot about dialogue tags. Because in many submissions characters didn’t “say” a thing. They shouted, they inquired, they assumed. Some characters screamed while others murmured. But no one “said” anything. And I started wondering why.

Why do we tell beginner writers to avoid creative dialogue tags in the first place? Why do we insist that characters should stick to “said,” “asked,” and the occasional “sighed?” And, if the advice is so of-repeated, why are writers still unable to resist the siren call of weep, scream, snap, or laugh?

The more I thought about it, the more I understood the temptation. We’re always encouraged to use strong, actionable verbs in our prose. Why walk when you can skip or wander? Why cry when you can sob or weep? Why wouldn’t we reach for exciting verbs instead of mild-boring dull-blah said? Why couldn’t each verb be a tiny sparkling gem in its own right?

The problem, I think, is that every jewel needs a setting to become something more than the sum of its parts. Without something to provide structure, a collection of the world’s most glorious diamonds would still only amount to a heap of rocks.

And a dialogue tag should never, ever be the diamond in any given sentence.

Dialogue is your diamond, friends. When we read your work, your dialogue should be so bright, so sparkling, so lifelike, so wonderfully realistic that our brains “hear” each line instead of merely reading it. We don’t need to be told a character is shouting — we can sense it in the way they spit out words, clench fists, or storm from the room.

A dialogue tag is a mere signpost along the narrative journey, gently indicating who said what. It’s part of a story’s experience, but it’s not part of the story itself, nor should it be treated as such. Dialogue tags are similar to lighting in a Broadway play: without it, the audience would have no idea what was going on, but it usually strives to shine without calling too much attention to itself.

What’s more, readers may not initially imagine a particular line being “sobbed.” When we reach the end of a sentence and find out our leading lady has actually sobbed instead of whispered, it pulls us right out of the story. We pause. We reread the line. We adjust our understanding and begin again. But that wonderful momentum when we’re fully immersed in the scene, holding our breath to find out what our heroine says next, is lost.

Creating a successful work of fiction is about giving the reader all the materials they need to build your fictional world in their mind and not a scrap more. Readers need believable dialogue. They need voices so compelling that they pop right off the page and into our ears. And if you’ve created dynamic characters who speak words we can really hear, you will never need to tell us how something was said.

Senior Editor

1. According to the Senior Editor, the beginner writers are tempted to ______.
A.replace a dull “said” with exciting verbs
B.omit what the character said in a dialogue
C.resist the warning against strong emotions
D.overuse the word “said” in their submissions
2. The Senior Editor compares dialogue tags to ______
A.glorious diamondsB.heaps of rocks
C.tiny, sparkling gemsD.Broadway play lighting
3. What can we learn from the passage?
A.Dialogue tags are said to be the most important aspect of storytelling.
B.Without dialogue tags, readers have to reread to adjust understanding.
C.Creative dialogue tags may interrupt readers’ wonderful reading flow.
D.Effective dialogue tags should describe characters’ emotions directly.
4. The writer most probably agrees that ______.
A.good works of fiction give as many materials as possible
B.readers cannot imagine a line without the dialogue tags
C.what was said should be prioritized over how it was said
D.writers should choose powerful words for dialogue tags
2024-05-13更新 | 91次组卷 | 1卷引用:北京市中国人民大学附属中学2023-2024学年高一下学期期中练习英语试题
阅读理解-阅读单选(约460词) | 较难(0.4) |
文章大意:本文为一篇说明文,说明了大脑并不是独立存在的,它对科学和医疗保健都有重要影响。

5 . For decades, scientists thought of the brain as the most closely guarded organ. Locked safely behind a biological barrier, away from the disorder of the rest of the body, it was broadly free of destruction of germs (病菌) and the battles started by the immune system.

Then, 20-odd years ago, some researchers began to ask a question: is the brain really so separate? The answer, according to a growing body of evidence, is no — and has important effects on both science and health care.

The list of brain conditions that have been associated with changes elsewhere in the body is long and growing. Changes in the make-up of the microorganisms resident in the gut (肠道), for example, have been linked to disorders like Parkinson’s disease. Some researchers think that certain infections could provoke Alzheimer’s disease and some could lead to emotional disorder in babies.

The effect is two-way. There is a lengthening list of symptoms (症状) not typically viewed as disorders of the nervous system in which the brain and the neural processes that connect it to the body play a large part. For example, the development of a fever is influenced by a population of neurons (神经元) that control body temperature and appetite. The effect of brain on body is underlined by the finding that stimulating a particular brain region in mice can ‘remind’ the body of previous inflammation (炎症) — and reproduce them.

These findings and others mark a complete shift in our view of the interconnectedness of brain and body, and could help us both understand and treat illness. If some brain conditions start outside the brain, then perhaps cures for them could also reach in from outside. Treatments that take effect through the digestive system, heart or other organs, for instance, would be much easier and less striking to give than those that must cross the blood-brain barrier, the brain’s first line of defence.

In the opposite direction, the effects of our emotions or mood on our capacity to recover from illness could also be used. There is an opening work under way testing whether stimulating certain areas of the brain that respond to reward and produce feelings of positivity could enhance recovery from conditions such as heart attacks. Perhaps even more exciting is the possibility that making changes to our behaviour — to reduce stress, say — could have similar benefits.

For neuroscientists, it’s time to look beyond the brain. And clinicians treating the body mustn’t assume the brain is above getting involved — its activity could be influencing a wide range of conditions, from mild infections to long-time fatness.

1. The author writes paragraph 1 mainly to ______.
A.evaluate an argument
B.present an assumption
C.summarize the structure
D.provide the background
2. What does the underlined word “provoke” mean in Paragraph 3?
A.Delay.B.Cure.C.Cause.D.Disturb.
3. What can we learn from the passage?
A.Treatments that cross brain-blood barrier are less used.
B.Previous diseases could cause the production of new ones.
C.Emotions could affect the capacity to fight against diseases.
D.Treatment of the brain takes priority over other treatments.
4. Which of the following shows the development of ideas in the passage?
I: Introduction P: Point Sp: Sub-point (次要点) C: Conclusion
A.B.
C.D.
2024-05-06更新 | 196次组卷 | 1卷引用:2024届北京市顺义区高三下学期二模英语试题
阅读理解-阅读表达(约330词) | 较难(0.4) |
文章大意:本文是一篇说明文。文章主要介绍了在充满了不确定性的生活当中,我们应该怎样应对这种不确定性。不要让担忧剥夺了对当下的享受削弱了自己能量,我们应该采取行动解决能解决的问题,过好当下。
6 . 阅读下面短文,根据题目要求用英文回答问题。

Uncertainty is all around us, never more so than today. Whether it concerns your health or relationships, much of what lies ahead in life remains uncertain.

We’re all different in how much uncertainty we can tolerate in life. Some people seem to enjoy taking risks and living unpredictable lives, while others find the randomness of life deeply annoying. But all of us have a limit. If you feel controlled by uncertainty and worry, it’s important to know that you’re not alone; many of us are in the same boat.

To cope with all this uncertainty, many of us use worrying as a tool for trying to predict the future and avoid unpleasant surprises. Worrying can make it seem like you have some control over uncertain circumstances. You may also believe that it will help you find a solution to your problems or prepare you for the worst. Unfortunately, long-term worrying just robs you of enjoyment in the present and weakens your energy. But there are healthier ways to cope with uncertainty.

Identify your uncertainty trigger (诱发因素). A lot of uncertainty tends to be self-generated. However, some can be generated by external sources, such as reading media stories that focus on bad news, or simply communicating with anxious friends. By recognizing your triggers, you can take action to avoid or reduce your exposure to them.

Shift your attention. Focus on solvable worries, taking action on those aspects of a problem that you can control, or simply go back to what you were doing. When the feelings of uncertainty return, refocus your mind on the present moment and your own breathing.

1. How are people different in tolerating uncertainty in life?
___________________________________________________________________________________________
2. Why do many people use worrying as a tool to deal with uncertainty?
___________________________________________________________________________________________
3. Please decide which part is false in the following statement, then underline it and explain why.
Knowing the triggers of your uncertainty, you can learn to expose yourself to them.
___________________________________________________________________________________________
4. What are you most uncertain about right now? How will you deal with it? (In about 40 words)
___________________________________________________________________________________________
2024-05-05更新 | 127次组卷 | 1卷引用:2024届北京市顺义区高三下学期二模英语试题
阅读理解-阅读单选(约450词) | 较难(0.4) |
文章大意:这是一篇说明文。文章主要讲科学家首次证明大脑电活动可解码并用于重构音乐,他们还期望该研究成果能助失语症患者恢复说话能力,未来需克服一些障碍才能将此技术应用于患者。

7 . Researchers hope brain implants will one day help people with aphasia(失语症) to get their voice back—and maybe even to sing. Now, for the first time, scientists have demonstrated that the brain’s electrical activity can be decoded and used to reconstruct music.

A new study analyzed data from 29 people monitored for epileptic seizures(癫痫发作), using electrodes(电极) on the surface of their brain. As participants listened to a selected song, electrodes captured brain activity related to musical elements, such as tone, rhythm, and lyrics. Employing machine learning, Robert Knight from UC Berkeley and his colleagues reconstructed what the participants were hearing and published their study results. The paper is the first to suggest that scientists can “listen secretly to” the brain to synthesize(合成) music.

To turn brain activity data into musical sound, researchers trained an artificial intelligence (AI)model to decode data captured from thousands of electrodes that were attached to the participants as they listened to the song while undergoing surgery. Once the brain data were fed through the model, the music returned. The model also revealed some brain parts responding to different musical features of the song.

Although the findings focused on music, the researchers expect their results to be most useful for translating brain waves into human speech. Ludovic Bellier, the study’s lead author, explains that speech, regardless of language, has small melodic differences—tempo, stress, accents, and intonation—known as prosody(韵律). These elements carry meaning that we can’t communicate with words alone. He hopes the model will improve brain-computer interfaces (BCI), assistive devices that record speech-associated brain waves and use algorithms to reconstruct intended messages. This technology, still in its infancy, could help people who have lost the ability to speak because of aphasia.

Future research should investigate whether these models can be expanded from music that participants have heard to imagined internal speech. If a brain-computer interface could recreate someone’s speech with the prosody and emotional weight found in music, it could offer a richer communication experience beyond mere words.

Several barriers remain before we can put this technology in the hands—or brains— of patients. The current model relies on surgical implants. As recording techniques improve, the hope is to gather data non-invasively, possibly using ultrasensitive electrodes. However, under current technologies, this approach might result in a lower speed of decoding into natural speech. The researchers also hope to improve the playback clarity by packing the electrodes closer together on the brain’s surface, enabling an even more detailed look at the electrical symphony the brain produces.

1. What can we learn from the study?
A.Electrodes can analyze musical elements.
B.The decoding of brain data helps recreate music.
C.Machine learning greatly enhances brain activity.
D.The AI model monitors music-responsive brain regions.
2. What hopefully makes it possible to expand the model to speech?
A.The prosody of speech.B.The collection of brain waves.
C.The emotional weight of music.D.The reconstruction of information.
3. Which of the following would be the best title for the passage?
A.Unlocking the Secrets of Melodic MindB.Brain Symphony: Synthesized Human Speech
C.BCI Brings Hope to People with AphasiaD.Remarkable Journey: Decoding Brain with AI
2024-04-26更新 | 437次组卷 | 1卷引用:2024届北京市海淀区高三下学期一模英语试题
阅读理解-阅读单选(约470词) | 较难(0.4) |
文章大意:这是一篇说明文。文章主要讲述了谦逊的好处。

8 . Have we reached the peak of the culture war? Looking at my social media feeds, it seems that polarised thinking and misinformation have never been more common. How am I supposed to feel when users I once admired now draw on questionable evidence to support their beliefs?

Perhaps it is time for us all to adopt a little “existential humility”. I came across this idea in a paper by Jeffrey Greenat Virginia from Common Wealth University and his colleagues. They build on a decade of research examining the benefits of “intellectual humility” more generally — our ability to recognise the errors in our judgement and remain aware of the limits of our knowledge.

You can get a flavour of this research by rating your agreement with the following statements, ranging from 1 (not at all like me) to 5 (very like me): I question my own opinions because they could be wrong; I recognise the value in opinions that are different from my own; in the face of conflicting evidence, I am open to changing my opinions.

People who score highly on this assessment are less likely to form knee-jerk reactions on a topic, and they find it easier to consider the strengths or weaknesses of a logical argument. They are less likely to be influenced by misinformation, since they tend to read the article in full, investigate the sources of a news story and compare its reporting to other statements, before coming to a strong conclusion about its truth.

Developing “intellectual humility” would be an excellent idea in all fields, but certain situations may make it particularly difficult to achieve. Greenat points out that some beliefs are so central to our identity that any challenge can activate an existential crisis, as if our whole world view and meaning in life are under threat. As a result, we become more insistent in our opinions and seek any way to protect them. This may reduce some of our feelings of uncertainty, but it comes at the cost of more analytical thinking.

For these reasons, Greenat defines “existential humility” as the capacity to entertain the thought of another world view without becoming so defensive and closed-minded. So how could we achieve it? This will be the subject of future research, but the emotion of awe (a feeling of great respect and admiration) may offer one possibility. One study found that watching awe-inspiring videos about space and the universe led to humbler thinking, including a greater capacity to admit weaknesses.

Perhaps we could all benefit from interrupting our despair with awe-inspiring content. At the very least, we can try to question our preconceptions before offering our views on social media and be a little less ready to criticize when others disagree.

1. Regarding the culture war on social media, the author is _______.
A.embarrassedB.concernedC.panickedD.stressed
2. What can be inferred from the passage?
A.Existential humility reduces the threat to identity.
B.People with intellectual humility tend to jump to conclusions.
C.Awe could promote existential humility by encouraging modest thinking.
D.The higher you score on the assessment, the more you stick to your values.
3. Which would be the best title for the passage?
A.Overcome an Existential CrisisB.Show a Little Humility
C.The Path to Screening InformationD.The Approach to Achieving Humility
2024-04-19更新 | 267次组卷 | 1卷引用:2024届北京市朝阳区高三下学期一模考试英语试题
阅读理解-阅读单选(约460词) | 较难(0.4) |
文章大意:本文是一篇说明文,主要讲的是作者对于同行评议不完美的原因的分析。

9 . When I teach research methods, a major focus is peer review. As a process, peer review evaluates academic papers for their quality, integrity and impact on a field, largely shaping what scientists accept as “knowledge”- By instinct, any academic follows up a new idea with the question, “Was that peer reviewed?”

Although I believe in the importance of peer review and I help do peer reviews for several academic journals-I know how vulnerable the process can be.

I had my first encounter with peer review during my first year as a Ph. D student. One day, my adviser handed me an essay and told me to have my -written review back to him in a week. But at the time, I certainly was not a “peer”-I was too new in my field. Manipulated data (不实的数据) or substandard methods could easily have gone undetected. Knowledge is not self-evident. Only experts would be able to notice them, and even then, experts do not always agree on what they notice.

Let’s say in my life I only see white swans. Maybe I write an essay, concluding that all swans are white. And a “peer” says, “Wait a minute, I’ve seen black swans.” I would have to refine my knowledge.

The peer plays a key role evaluating observations with the overall goal of advancing knowledge. For example, if the above story were reversed, and peer reviewers who all believed that all swans were white came across the first study observing a black swan, the study would receive a lot of attention.

So why was a first-year graduate student getting to stand in for an expert? Why would my review count the same as an expert’s review? One answer: The process relies almost entirely on unpaid labor.

Despite the fact that peers are professionals, peer review is not a profession. As a result, the same over-worked scholars often receive masses of the peer review requests. Besides the labor inequity, a small pool of experts can lead to a narrowed process of what is publishable or what counts as knowledge, directly threatening diversity of perspectives and scholars. Without a large enough reviewer pool, the process can easily fall victim to biases, arising from a small community recognizing each other’s work and compromising conflicts of interest.

Despite these challenges, I still tell my students that peer review offers the best method for evaluating studies aird advancing knowledge. As a process, peer review theoretically works. The question is whether the issues with peer review can be addressed by professionalizing the field.

1. What can we learn about peer review in the first paragraph?
A.It generates knowledge.B.It is commonly practiced.
C.It is a major research method.D.It is questioned by some scientists.
2. What can be inferred about the example of swans?
A.Complexity of peer review ensures its reliability.
B.Contradictions between scientists may be balanced.
C.Individuals can be limited by personal experiences.
D.Experts should detect unscientific observation methods.
3. What is the author’s major concern about peer review?
A.Workload for scholars.B.Toughness of the process.
C.Diversification of publications.D.Financial support to reviewers.
4. The passage is mainly about ______.
A.what fuels peer reviewB.why peer review is imperfect
C.how new hands advance peer reviewD.whether peer reviewers are underrated
2024-04-16更新 | 365次组卷 | 2卷引用:2024届北京市东城区高三下学期综合练习(一)(一模)英语试题
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文章大意:这是一篇说明文,本文主要讲述两个研究小组为了揭示与发生过敏有关的细胞进行研究,最终确定了特定的记忆B细胞。

10 . While some allergies (过敏症) disappear over time or with treatment, others last a lifetime. For decades, scientists have been searching for the source of these lifetime allergies.

Recently, researchers found that memory B cells may be involved. These cells produce a different class of antibodies known as IgG, which ward off viral infections. But no one had identified exactly which of those cells were recalling allergens or how they switched to making the IgE antibodies responsible for allergies. To uncover the mysterious cells, two research teams took a deep dive into the immune (免疫的) cells of people with allergies and some without.

Immunologist Joshua Koenig and colleagues examined more than 90, 000 memory B cells from six people with birch allergies, four people allergic to dust mites and five people with no allergies. Using a technique called RNA sequencing, the team identified specific memory B cells, which they named MBC2s that make antibodies and proteins associated with the immune response that causes allergies.

In another experiment, Koenig and colleagues used a peanut protein to go fishing for memory B cells from people with peanut allergies. The team pulled out the same type of cells found in people with birch and dust mite allergies. In people with peanut allergies, those cells increased in number and produced IgE antibodies as the people started treatment to desensitize them to peanut allergens.

Another group led by Maria Curotto de Lafaille, an immunologist at the Icahn School of Medicine at Mount Sinai in New York City, also found that similar cells were more plentiful in 58 children allergic to peanuts than in 13 kids without allergies. The team found that the cells are ready to switch from making protective IgG antibodies to allergy-causing IgE antibodies. Even before the switch, the cells were making RNA for IgE but didn’t produce the protein. Making that RNA enables the cells to switch the type of antibodies they make when they encounter allergens. The signal to switch partially depends on a protein called JAK, the group discovered. “Stopping JAK from sending the signal could help prevent the memory cells from switching to IgE production,” Lafaille says. She also predicts that allergists may be able to examine aspects of these memory cells to forecast whether a patient's allergy is likely to last or disappear with time or treatment.

“Knowing which population of cells store allergies in long-term memory may eventually help scientists identify other ways to kill the allergy cells,” says Cecilia Berin, an immunologist at Northwestern University Feinberg School of Medicine. “You could potentially get rid of not only your peanut allergy but also all of your allergies.”

1. Why did scientists investigate the immune cells of individuals with and without allergies?
A.To explore the distinctions between IgG and IgE.
B.To uncover new antibodies known as IgG and IgE.
C.To identify cells responsible for defending against allergies.
D.To reveal cells associated with the development of allergies.
2. What does the word “desensitize” underlined in Paragraph 4 most probably mean?
A.Make. . . less destructive.B.Make. . . less responsive.
C.Make. . . less protective.D.Make. . . less effective.
3. What can we learn from the two research teams’ work?
A.MBC2s make antibodies and proteins that prevent allergies.
B.Memory B cells generate both RNA for IgE and the corresponding protein.
C.JAK plays a role in controlling antibody production when exposed to allergens.
D.Allergists are capable of predicting whether an allergy will last or disappear.
4. Which could be the best title for the passage?
A.RNA Sequencing Is Applied in Immunology Research
B.Specific Cells Related to Peanut Allergies Are Identified
C.Unmasking Cells’ Identities Helps Diagnose and Treat Allergies
D.Newfound Immune Cells Are Responsible for Long-lasting Allergies
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