Scientists have developed a blood test to diagnose Alzheimer’s disease without the need for expensive brain imaging or a painful lumbar puncture, where a sample of cerebrospinal (脑脊髓的) fluid (CSF) is drawn from the lower back.
Current guidelines recommend detection of three distinct markers: abnormal accumulations of amyloid (淀粉样蛋白) and tau proteins, as well as neurodegeneration—the slow and progressive loss of neuronal cells (神经元细胞) in specified regions of the brain. This can be done through a combination of brain imaging and CSF analysis. However, a lumbar puncture can be painful and people may experience headaches or back pain after the procedure, while brain imaging is expensive and takes a long time to schedule. Thomas Karikari at the University of Pittsburgh, who was involved in the study, said,” A lot of patients, even in the US, don’t have access to MRI and PET scanners. Accessibility is a major issue.”
The development of a reliable blood test would be an important step forwards. “A blood test is cheaper, safer and easier to conduct, and it can improve clinical confidence in diagnosing Alzheimer’s and selecting participants for clinical trial and disease monitoring,” Karikari said.
Although current blood tests can accurately detect abnormalities in amyloid and tau proteins, detecting markers of nerve cell damage that are specific to the brain has been harder. Karikari and his colleagues around the world focused on developing an antibody-based blood test that would detect a particular form of tau protein called brain-derived tau,which is specific to Alzheimer’s disease.
They tested it in 600 patients at various stages of Alzheimer’s and found that levels of the protein correlated well with levels of tau in the CSF,and could reliably distinguish Alzheimer’s from other neurodegenerative diseases.
The next step will be to validate the test in a broader range of patients, including those from varied racial backgrounds, and those suffering from different stages of memory loss or other potential dementia symptoms.
1. What does Paragraph 2 mainly talk about concerning the current detection method?A.Its reliability | B.Its importance | C.Its complexity. | D.Its disadvantages |
A.They created a blood test to detect brain-derived tau. |
B.They developed a medicine to cure Alzheimer’s disease. |
C.They found a way to safely draw CSF from patients’back. |
D.They discovered protein to help diagnose Alzheimer’s disease. |
A.Invent. | B.Confirm | C.Forecast. | D.Prohibit. |
A.To raise people’s awareness of Alzheimer’s disease. |
B.To question a common view about Alzheimer’s disease. |
C.To introduce an approach to detecting Alzheimer’s disease. |
D.To provide evidence for the symptoms of Alzheimer’s disease. |
相似题推荐
【推荐1】X-rays are high energy waves that are invisible.
X-rays are valuable in medicine because then can see through certain parts of the body. Doctors can take pictures to see which bones are broken or to find out which teeth have holes. The X-rays are strong enough to pass through the skin and muscles,but they cannot pass through hard objects like bones. In the picture,hard objects like bones are white area
There are some situations in which X-rays cannot give you a clear picture. Some organs,for example,may prevent X-rays from showing a broken bone. For this reason,computed tomography(CT)was invented. A person is put inside a scanner,which is a large tube-shaped machine.
A.Then the person is X-rayed from all sides. |
B.Objects that X-rays go through appear dark. |
C.In mathematics,X means something unknown. |
D.An X-ray machine is used to take these pictures. |
E.X-rays,however,can also do harm to your body. |
F.However,they can be an essential tool for finding out what's wrong with you. |
G.They are useful because they can pass through many things that normal light cannot. |
【推荐2】Health chiefs are to use artificial intelligence to screen and treat people at risk of hepatitis C (丙型肝炎) under plans to wipe out the life-threatening disease by 2030.
The National Health Service (NHS) scheme, due to start within weeks in England, aims to identify thousands of patients unaware that they have the virus so that treatment can be given before it is too late. Staff will use AI to comb through patient health records and look for significant risk factors, such as historical blood transfusions (输血) or an HIV diagnosis. Hepatitis C often has no noticeable symptoms until the liver is severely damaged, which means the infected party may not know they are living with a potential killer. It can be cured with modern treatments.
Anyone identified by the AI software will be invited for a consultation by their doctors and, if necessary, will experience further screening for hepatitis C. Patients who test positive for the virus — which can be caught from contact with the blood of an infected person, such as by sharing a needle — will be offered antiviral medicines after NHS England struck a deal with three drug companies. Professor Graham Foster, the national clinical chairman for NHS England’s hepatitis C elimination (消灭) programmes, described the scheme as “a significant step forward” in the fight to eliminate the virus.
Hepatitis C deaths fell by 35 percent in the five years to 2020, from 482 to 314, according to the latest data from the UK Health Security Agency. The fall in deaths was thanks to earlier detection of the virus and improved access to treatments, health experts said.
NHS staff will also visit at-risk communities in specially equipped vans (货车), to test for the virus and carry out liver health checks, in a bid to wipe out the virus in England before the 2030 goal set by the World Health Organization.
1. What is the purpose of the NHS scheme?A.To make the most of artificial intelligence. |
B.To record the blood transfusions in the history. |
C.To diagnose the patients with serious unnoticeable symptoms. |
D.To pick out the potential patients to provide timely treatments. |
A.NHS scheme can be helpful in removing the hepatitis C virus. |
B.Hepatitis C can be spread through contact with blood of patients. |
C.All the patients have to be re-examined again for the hepatitis C. |
D.Related consulting service will be arranged by the doctor for free. |
A.Because the related figure was updated on time. |
B.Because the liver healthy check-ups were scheduled. |
C.Because the virus was discovered earlier and better treatments were available. |
D.Because the virus was tested in advance and communities were well-equipped. |
A.Hepatitis C is a life-threatening disease. |
B.Hepatitis C deaths in the UK have declined. |
C.NHS scheme helps to kill the hepatitis C virus. |
D.AI is a new weapon against deadly hepatitis C. |
【推荐3】William Cary said he has learned to appreciate small victories with his 17-year-old son Ben, who has autism and doesn’t speak, so he choked up while describing how proud he was when Ben buttoned his pants for the very first time after going to the bathroom. But one victory that Ben achieved long ago was surfing. Since the age of six, he has been participating in Surfers Healing surf camps for children with autism.
The annual event returned recently to Tourmaline Surf Park in California. More than 150 children took turns riding the waves with 15 professional surfers as well as a small group of volunteers. Ben could hardly wait to get in the water with surfer Graham. Within minutes of hitting the sand, Ben mounted a long board (冲浪板) and Graham gently pushed him out into the thigh-high surf. Graham, who has an 11-year-old son with autism, said he’s seen firsthand how children immediately transform when they’re rolling in the ocean waves.
Surfers Healing was started 20 years ago by surfer Izzy Paskowitz and his wife, Danielle. One day while in Hawaii, their son Isaiah had a meltdown (情绪失控) on the beach and Izzy tried to distract the boy by tossing him into the waves. Suddenly, the boy’s anger was replaced by smiles and wonder, and Surfers Healing was born. Each year, the foundation hosts 25 camps around the world serving more than 5,000 autistic children, ranging in age from 3 to 25. About half of the group participating recently was new to the sport.
Paskowitz said the ocean has a healing power on people with autism. The rhythm of the waves calms them, and the sounds, sights, textures and temperatures create such a sensory overload (负荷) that it forces the mind to focus. Many of the children arriving at the beach initially covered their ears from the crash of the waves, but gradually these sensitivities disappeared. One teen camper who traveled with her mom from Arizona wouldn’t get out of the car for more than an hour. Finally, she was coaxed (哄骗) to take a brief ten-minute ride in the knee-high waves on a body board. As she returned to shore, a volunteer awarded her a small trophy for participation.
1. What was most probably the reason why Cary choked up?A.He was proud that his son was a good surfer. |
B.He achieved a small victory. |
C.He took pride in his autistic son learning to take care of himself. |
D.He was too surprised to see his autistic son button his own pants. |
A.Ben has suffered from autism since he was six. |
B.Around 150 people took part in the recent surfing event in Tourmaline Surf Park. |
C.Autistic people usually range in age from 3 to 25. |
D.Surfing is so stimulating to our senses that it forces autistic children to focus. |
A.It was initiated 20 years ago by a foundation. |
B.A boy went crazy on the beach of Hawaii two decades ago. |
C.Surfer Izzy Paskowitz and his wife realized the healing effects of surfing 20 years ago. |
D.Surfer Izzy Paskowitz’s son was cured of autism by surfing two decades ago. |
A.From Chaos to Peace | B.Surfing Washes Away Autism Symptoms |
C.The Surfers’ Club | D.Transforming Powers of Surfing |
【推荐1】Home Laundry Automatic Dryer Product
Full Two Year Warranty(保修)
Limited Five Year Warranty on Cabinet(机箱)
Warranty Provides for:
FIRST TWO YEARS Amana will repair or replace any faulty part free of charge.
THIRD THRU FIFTH YEARS Amana will provide a free replacement part for any cabinet which proves faulty due to rust (生锈) .
Warranty Limitations:
• Warranty begins at date of original purchase.
• Applies only to product used within the United States or in Canada if product is approved by Canadian Standards Association when shipped from factory.
• Products used on a commercial or rental basis are not covered by this warranty.
• Service must be performed by an Amana servicer.
• Adjustments covered during first year only.
Warranty Docs Not Cover It If :
• Product has damage due to product alteration, connection to an improper electrical supply, shipping and handling, accident, fire, floods, lightning or other conditions beyond the control of Amana.
• Product is improperly installed or applied.
Owner’s Responsibilities:
• Provide sales receipt.
• Normal care and maintenance.
• Having the product reasonably accessible for service.
• Pay for service calls related to product installation or usage instructions.
• Pay for extra service costs, over normal service charges, if servicer is requested to perform service outside servicer’s normal business hours.
• In no event shall Amana be responsible for consequential damages.
• This warranty gives you specific legal rights, and you may have others which vary from state to state. For example, some states do not allow the exclusion or limitation of consequential damages, so this exclusion may not apply to you. (268 words)
1. According to Warranty Limitations, a product can be under warranty if __________.
A.shipped from a Canadian factory | B.rented for home use |
C.repaired by the user himself | D.used in the U.S.A. |
A.the loss of the sales receipt | B.a servicer’s overtime work |
C.the product installation | D.a mechanic’s transportation |
A.Consequential damages are excluded across America. |
B.A product damaged in a natural disaster is covered by the warranty. |
C.A faulty cabinet due to rust can be replaced free in the second year. |
D.Free repair is available for a product used improperly in the first year. |
【推荐2】People trained to detect lies often rely on multiple signs, such as eye contact, length of responses and the details in what people say, but studies have shown that assessing a wide range of behavioral information can make it harder to decide if someone is lying. Bruno Verschuere at the University of Amsterdam and his colleagues wondered whether solely focusing on the detail of statements could provide more consistent results.
To test this idea, researchers asked 44 students to go for a walk or steal from a mock(模仿的)crime. Students were instructed to lie if they committed the fake theft.
Next, the researchers recruited 171 people to watch six truthful and six deceptive(欺骗的) interviews from these recordings, ranking interviewees’ eye contact and detail level. The results revealed that both truth-tellers and liars averted (转移) their gaze a similar amount, but truthful statements were substantially more detailed than deceptive ones, suggesting the latter is a more useful way to tell that someone is lying.
The researchers then asked 405 people to judge the true nature of six truthful and six deceptive statements randomly chosen from the interviews. Around half of the participants used multiple cues to identify liars. The remaining participants solely ranked the level of detail in answers on a scale of 1 to 10, with l a 6 or above counting as truthful. Those using multiple cues distinguished lies from the truth 59% of the time, while those relying solely on detail achieved 66%.
“Our take is that using just one cue can provide a simpler way to judge lies from the truth,” says Verschuere. Nevertheless, in the real world, you would probably need to confirm the accuracy of statements through extra further investigations or follow-up questions, he says.
1. Bruno Verschuere and his colleagues conducted the research to confirm that__________.A.behavioral information played a vital role in finding out the truth |
B.it’s relatively easier to identify liars by relying only on the detail of statements |
C.truhtellers and liars shared something in common when performing the task |
D.people should be trained to detect lies by referring to multiple cues |
A.Truthful statements included considerably more details than deceptive ones. |
B.Liars turned away their eyes more often than truth—tellers. |
C.It’s difficult for participants to detect liars by using multiple cues like eye contact. |
D.Participants who relied on one cue pan distinguish lies from the truth faultlessly. |
A.It had no potential market | B.It made no sense. |
C.It could be perfectly applied. | D.It had some limitations. |
A.To introduce readers to the classification of fies. |
B.To encourage readers to apply the results in real life. |
C.To inform readers of scientific findings on detecting liars. |
D.To warn readers of psychological harm of telling a lie. |
【推荐3】A research team led by UCLA materials scientists has shown ways to make super white paint that reflects as much as 98% of incoming heat from the sun. The advance shows practical pathways for designing paints that, if used on rooftops and other parts of a building, could greatly reduce cooling costs, beyond what standard white cool-roof paints can achieve.
“When you wear a white T-shirt on a hot sunny day, you feel cooler than if you wear one that’s darker in color — that’s because the white shirt reflects more sunlight and it’s the same concept for buildings,” said Aaswath Raman, a researcher of the study. “A roof painted white will be cooler inside than one in a darker shade by rejecting heat at infrared (红外线的) wavelengths, which we humans cannot see with our eyes. This super white paint could allow buildings to cool down even more by radiative(辐射的) cooling.”
The best performing white paints now available typically reflect around 85% of incoming sun heat. The remainder is absorbed by the chemical makeup of the paint. The researchers showed that simple changes in a paint's ingredients could offer a big jump, reflecting as much as 98% of incoming radiation. The potential cooling benefits this super white paint can achieve may be realized in the near future because the changes suggested are within the abilities of the paint and coatings industry.
Many cities and governments, including the state of California and New York City, have started to encourage cool-roof technologies for new buildings. “We hope that the work will inspire future creativity in super-white coatings for not only energy savings in buildings, but also lessening the heat island effects of cities, and perhaps even showing a practical way that, if applied globally, could affect climate change,” said Raman, who has studied cooling paint technologies for several years, “This would require experts in diverse fields to work together.”
1. What’s the function of the super white paint?A.Reflecting all the sun heat. | B.Lowering building costs. |
C.Keeping buildings cool. | D.Absorbing heat quickly. |
A.By telling a story. | B.By listing scientific data. |
C.By conducting all experiment. | D.By making a similar comparison. |
A.It is completely chemical free. | B.It is still unavailable in the market. |
C.Its ingredients still need improving. | D.Is effects have been greatly improved. |
A.He has high expectations of it. | B.He urges greater attention to it. |
C.He believes it can stop climate change. | D.He thinks it’s easy to carry out worldwide. |