A new generation of opioids (阿片类药物) with fewer side effects is being explored by an Australian and Chinese research team.
Professor Maree Smith from the University of Queensland will present research on oliceridine being developed internationally, as well as results of her team’s CYX-6 research project on Saturday at a meeting to be held by Faculty of Pain Medicine (FPM) of the Australian and New Zealand College of Anaesthetists during October 19-21 in Cairns.
Professor Smith’s laboratory is exploring the new opioid, together with the Chinese researcher, Professor Li Tingyou from Nanjing Medical University. She stressed that while the research project was still in its early stages and would consume much more time and energy, laboratory tests had found that a newly discovered compound (复合物), CYX-6, spared laboratory rats from some of the more common side effects of opioids. Strong opioids that are now used for pain relief can have serious and sometimes deadly side effects, such as breathing problems.
“We’ve seen that in the US there are many people who are dying as a result of taking too many opioids because they stop breathing,” Professor Smith explained. “Though it’s difficult, we are focusing on discovery of new opioid alternatives with a reduced risk of breathing difficulty. It is a hot topic in the research world at present. Our application of the compound would be a very positive step.”
Dr. Meredith Craigie, Dean of FPM, said opioid alternatives with fewer side effects like the one that is being investigated by Professor Smith required thorough study, and research into the possible unknown side effects of new opioids was an especially significant step in the development of potential new treatments for pain.
1. What is oliceridine?A.An effective treatment. | B.A new opioid. |
C.A kind of operation. | D.A piece of equipment. |
A.It is found in the body of rats. | B.It is a compound used for pain relief. |
C.It prevents some side effects of opioids. | D.It is newly invented by Professor Smith. |
A.Expensive. | B.Promising. | C.Popular. | D.Risky. |
A.Testing the side effects of new opioids. | B.Inventing opioids with better effects. |
C.Developing new treatments for pain. | D.Using medicine for breathing difficulty. |
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【推荐1】A Wisconsin man made international headlines this week after a dog lick led to a rare infection resulting in the loss of part of his legs and arms. Greg Manteufel, 48, was diagnosed with a blood infection from capnocytophaga canimorsus, a bacterium found in dog and cat mouths. Doctors believe Manteufel became infected after his body was touched by a dog’s tongue. Manteufel’s case was serious.
Capnocytophaga is a bacterium found in the mouths of dogs, cats and even humans, and is considered normal, according to the CDC. Up to 74 percent of dogs and 57 percent of cats have some form of capnocytophaga in their mouths. There are many species of capnocytophaga. One of those species—capnocytophaga canimorsus, commonly found in dog and cat mouths—can potentially cause serious infection when passed on to humans.
It’s possible to test pets for the presence of the bacteria, but an animal might have the bacteria one day but not have it the next, according to the CDC. And it’s not practical to treat animals with medicine to get rid of the bacteria because it’s a normal part of their biology.
People are typically infected with capnocytophaga canimorsus from an animal bite, usually a dog bite. Some people, like Manteufel, become infected without a bite, if an animal carrying the bacteria licks them and the saliva touches an open area on the skin, like a cut.
The bacterium is common, but becoming seriously ill from an infection is not. “It’s just really, really, really rare,” said Scott Weese, a professor at Ontario Veterinary College’s Centre for Public Health and Zoonoses. “The risk caused by a dog is really low. Most dogs are carrying this bacterium in their mouth, but few people get sick.” Experts don’t know exactly how many people get infected with capnocytophaga annually because there’s no centralized record of cases. But all agree that serious infections happen once in a blue moon.
1. What happened to Greg Manteufel?A.He got bitten by a dog. | B.He fell seriously ill after kissing a dog. |
C.He got an infection after a severe injury. | D.He was seriously infected by a dog’s lick. |
A.Dogs and cats can be dangerous. | B.Capnocytophaga can spread very fast. |
C.Capnocytophaga is a common bacterium. | D.Dogs and cats can avoid capnocytophaga. |
A.It can save their life. | B.It makes no difference. |
C.It’s commonly performed. | D.It can help avoid the bacteria. |
A.It can put dogs in danger. | B.It is usually not easy to find. |
C.Severe infections of it are very rare. | D.Completely getting rid of it is possible. |
【推荐2】For years, doctors have given blood to patients who need it to survive. These “transfusions (输血)” usually involve giving red blood cells to patients.
Blood transfusions aren’t as simple as taking blood from one person and giving it to someone else. There are several different blood types, and they don’t all mix well. If someone gets a transfusion of the wrong kind of blood, their body will reject the blood cells, causing problems.
A new trial is being carried out in the United Kingdom. What’s new in the experiment is that people are being given red blood cells that were created in a laboratory. The scientists used stem cells from a blood sample to grow billions of brand new red blood cells. So the red blood cells in the experiment never actually existed inside anyone.
There are several reasons why this could be even better than a regular blood transfusion. For one thing, the red blood cells that are created can be adjusted for people with different blood types. That will be extremely helpful for people with rare blood types.
Also, the red blood cells created are brand new, meaning they last longer. Red blood cells live for about 120 days. A normal transfusion has red blood cells of all different ages. That means only a part of them are brand new. If the lab-created red blood cells last longer, it could mean that patients will need fewer transfusions.
To test the safety of the lab-grown red blood cells, researchers have given a couple of teaspoons of lab-created blood to two healthy people. Both people seem to be doing just fine after the transfusions. In all, the red blood cells from the lab will be tested on 10 people, and compared to normal transfusions.
The new process isn’t expected to replace normal blood transfusions, which will remain hugely important. Though the technology level has improved, growing red blood cells in a lab is extremely expensive. And a lot of work and testing still need to be done.
But if it’s successful, in the future the process could make life much easier for patients who often need transfusions—even those with rare blood types.
1. What does paragraph 2 mainly talked about?A.The process of blood transfusions. |
B.The concept of blood transfusions. |
C.The importance of blood transfusions. |
D.The possible problems in blood transfusions. |
A.They can live longer. |
B.They can convey more oxygen. |
C.The majority of them are brand new. |
D.They are targeted at those with rare blood. |
A.The high risk. |
B.Their high cost. |
C.The technology level. |
D.The lack of qualified labs. |
A.Artificial Blood Will Catch on |
B.Regular Blood Transfusion Will Be Safer |
C.Scientists Test Blood Grown in a Laboratory |
D.Patients Are Benefiting from Newly-Created Blood |
【推荐3】Dr. Sara McLin thought she made the right choice by going to an in-network emergency room near her Florida home after her 4-year-old burned his hand on a stove last Memorial Day weekend.
Her family is insured through her husband’s employer, HCA Healthcare, a Nashville-based health system that operates more hospitals than any other system in the nation. So McLin knew that a nearby stand-alone emergency room, HCA Florida Lutz Emergency, would be in their plan’s provider network.
But McLin said a doctor there told her she couldn’t treat her son, Keeling, because he had second- and third-degree burns that needed a higher level of care. The doctor referred them to the burn center at HCA Florida Blake Hospital, about a 90-minute drive away.
McLin, who is a dentist, said the doctor told her the stand-alone ER would not charge for the visit because they did not provide treatment.
“I don’t remember exactly how she phrased it, but something along the lines of--we won’t even call this a visit, because we can’t do anything. ” McLin said.
At Blake Hospital, a doctor diagnosed Keeling with a second-degree burn, bandaged his hand, and sent them home with instructions on how to care for the wound.
“I didn’t think anything more of it. ” McLin said.
Then the bills came.
Total Bill: For the emergency room visit, Envision Physician Services billed $829 to insurance and about $72 to the family. HCA Florida Trinity Hospital billed Keeling about $129, noting it had applied an “uninsured discount”. A list showed the original charge had been nearly $1, 509 before adjustments and discounts.
She said she called her insurer, United Healthcare, and a representative told her not to pay the bill.
After being contacted by KHN, Aliese Polk, an Envision spokesperson, said in an email that Envision would give up the debt, apologizing to Keeling’s family “for the misunderstanding. ”
1. What does Paragraph 3 focus on?A.A doctor’s suggestion. | B.Mclin’s anxiety. |
C.Treatment to Mclin’s son. | D.The location of Bcahe hospital. |
A.Fee from insurance service. |
B.Original charge from hospital bill. |
C.Family fee from insurance service. |
D.A share from insurance and discounts from hospital bill. |
A.The doctor at the emergency room healed Keeling’s burn. |
B.Alises Polk’s dealing with the bill can be satisfying to Mclin’s family. |
C.The doctor at Blake Hospital was impatient, treating Mclin’s lovely son. |
D.Mclin’s little son was burned on a stove but the hospital simply refused him. |
A.A treatment accident. | B.A scientific report. |
C.A medical bill. | D.An interview report. |
【推荐1】In the 1970s, chemist James Lovelock and microbiologist Lynn Margulis developed the Gaia hypothesis(盖亚假说): all organic and inorganic components on the planet are part of one self-regulating system, working to maintain life on earth. Scientists agree that we need take significant action to control emissions(排放). But where scientists and popular movements have thus far failed to convince the world to act, it seems that Mother Earth may have succeeded, with the never-before-seen COVID-19.
COVID-19 is estimated to have reduced carbon dioxide emission in China by a quarter. It caused factories to shut down, and slowed construction activities. Recent analysis shows a 70 percent drop in flights in February compared with January. And even getting into a car and going to a restaurant, shopping mall, or concert poses a risk of infection, which means that many people are choosing to stay at home and are consuming less, resulting in a significant reduction of their carbon footprints.
Of course, China and the rest of the world will hope to restart normal production and consumption as soon as the virus is under control. However, some positive measures have already been taken as a result of COVID-19. As the virus is thought to originate from wildlife, Chinese authorities are revising laws and regulations regarding the country's massive wildlife trade in order to prevent future epidemics(流行病)—a win for biodiversity.
The deaths of thousands of people worldwide should also serve as a lasting reminder of the fragility of life. We humans frequently ignore or repress uncomfortable thoughts of death and extinction. We would rather get on with our lives as usual, thinking everything will somehow work out in the end. Only in the face of suffering and death are we forced to view the bigger, longer-term perspective—and this is what is needed in order to react appropriately to climate change. COVID-19 has sent alarm bells ringing throughout the world.
1. What does the author mention the Gaia hypothesis for?A.To tell the main idea of the text. |
B.To introduce the topic for discussion. |
C.To show the need to protect the planet. |
D.To stress the importance of self-regulating system. |
A.The unexpected benefit of COVID-19. |
B.The economic influence of COVID-19. |
C.The preventive measures for COVID-19. |
D.The possible causes of COVID-19. |
A.Control. | B.Hold. |
C.Vary. | D.Test. |
A.It's urgent to fight the virus. |
B.The virus has caused many deaths. |
C.Life is fragile in face of disasters. |
D.Action is needed for climate change. |
【推荐2】Feeding bread to the ducks is a fond pastime for many of us, reminding us of our happy childhood trips to the local park. But did you know that bread actually poses a danger to birds, as well as the environment? Eating it can cause our feathered friends to develop a condition called Angel Wing, which is when too much bread makes birds’ feathers grow too quickly. This additional weight puts a strain on their muscles, causing their wings to twist and drop open, and if not treated fast, they can lose the ability to fly.
“Angel Wing can be remedied if we reach birds before it has developed too severely,” says Caroline Simpson, a trustee of UK charity Swan Lifeline, which has rescued and treated more than 30,000 birds over the last 20 years. “Otherwise the consequence can be awful—such as amputations of the wing.” Adult swans can also develop gut and heart disease, so it’s important we do our bit to prevent this by feeding wild birds with the right kind of food.
Bread can also cause harmful changes to the natural ecosystem. Rotting bread at the bottom of rivers and lakes allows bacteria to breed, spreading disease and attracting rats and other vermin to our waterways. It can result in algal blooms and the presence of a mould called Aspergillus too, which has the potential to kill waterfowl and other wildlife if it gets into their lungs.
But this doesn’t mean we have to stop fun trips to feed the ducks. Giving birds the right food—like frozen peas, sweetcorn and lettuce leaves—is good for both them and the environment. So, next time you visit your local park, take a healthier alternative with you and do your bit to protect our precious wildlife.
1. The underlined word “remedied” in Paragraph 2 probably means ________.A.reduced | B.expected | C.caused | D.corrected |
A.Harmful creatures will be drawn to waterways. |
B.Water birds will be overfed and risk losing their bodily functions. |
C.The water will be enriched thanks to the nutrients in bread. |
D.The eco-balance at the bottom of rivers or lakes will be disturbed. |
A.stop people from feeding waterfowl. |
B.instruct people how to raise waterfowl. |
C.warn people of the danger threatening waterfowl. |
D.promote a safe and healthy way to feed waterfowl. |
【推荐3】 We know that every person has its own words or expressions to express his ideas and feelings. Some of these words and expressions are commonly used for many years. Others are popular for just a short time. One such American expression is “Where’s the beef ?” It is used when something is not as good as it is said to be. In the early 1980’ s “Where’s the beef ?” was one of the most popular expressions in the United States. It seemed as if everyone using it at the time.
Beef, of course, is the meat from a cow, and probably no food is more popular in America than a hamburger made from beef. In the 1960s a businessman named Ray Kroc began building small restaurants that sold hamburgers at a low price. Kroc called his restaurant “McDonald's”. Kroc cooked hamburgers quickly so people in a hurry could buy and eat them without waiting. By the end of the 1960s the McDonald's Company had been selling hamburgers in hundreds of restaurants from California to Maine. Not surprisingly, Ray Kroc became one of the richest businessmen in America.
Other business people watched his success. Some of them opened their own hamburgers restaurants. One company, called “Wendy's”, began to compete with McDonald's. Wendy' s said its hamburgers were bigger than those sold by McDonald's or anyone else. The Wendy's hamburgers were the biggest. It produced a television advertisement to sell this idea. The Wendy's television advertisement showed three old women eating hamburgers. The bread that covered the meat was very big, but inside there was only a tiny bit of meat. One of the women said she would not eat a hamburger with such a little piece of beef. “Where's the beef?” She shouted in a funny voice. These advertisements for Wendy's hamburger restaurants were a success from the first day they appeared on television. As we said, it seemed that everyone began using the expression “Where's the beef?”
It was one of the most popular expressions in the United States.
1. McDonald is a restaurant .A.which sells fast food |
B.which sells cheap beef |
C.where people can eat whatever they like |
D.where people must eat in a hurry |
A.all over the world | B.all over America |
C.from east to west | D.from north to south |
A.try to find the best beef |
B.the beef can't be found |
C.the beef is not as good as it is said to be |
D.something is not as good as described |
A.McDonald | B.Wendy |
C.a rich businessman | D.Ray Kroc |
A.Some others wanted to open hamburger restaurants because hamburgers are easy to make. |
B.Some others wanted to open hamburger restaurants because they wanted to make a lot of money. |
C.Some others wanted to open hamburger restaurants because they could sell hamburgers from California to Maine. |
D.Some others wanted to open hamburger restaurants because they thought hamburgers are good to eat. |