4 . While some allergies (过敏症) disappear over time or with treatment, others last a lifetime. For decades, scientists have been searching for the source of these lifetime allergies.

Recently, researchers found that memory B cells may be involved. These cells produce a different class of antibodies known as IgG, which ward off viral infections. But no one had identified exactly which of those cells were recalling allergens or how they switched to making the IgE antibodies responsible for allergies. To uncover the mysterious cells, two research teams took a deep dive into the immune (免疫的) cells of people with allergies and some without.

Immunologist Joshua Koenig and colleagues examined more than 90, 000 memory B cells from six people with birch allergies, four people allergic to dust mites and five people with no allergies. Using a technique called RNA sequencing, the team identified specific memory B cells, which they named MBC2s that make antibodies and proteins associated with the immune response that causes allergies.

In another experiment, Koenig and colleagues used a peanut protein to go fishing for memory B cells from people with peanut allergies. The team pulled out the same type of cells found in people with birch and dust mite allergies. In people with peanut allergies, those cells increased in number and produced IgE antibodies as the people started treatment to desensitize them to peanut allergens.

Another group led by Maria Curotto de Lafaille, an immunologist at the Icahn School of Medicine at Mount Sinai in New York City, also found that similar cells were more plentiful in 58 children allergic to peanuts than in 13 kids without allergies. The team found that the cells are ready to switch from making protective IgG antibodies to allergy-causing IgE antibodies. Even before the switch, the cells were making RNA for IgE but didn’t produce the protein. Making that RNA enables the cells to switch the type of antibodies they make when they encounter allergens. The signal to switch partially depends on a protein called JAK, the group discovered. “Stopping JAK from sending the signal could help prevent the memory cells from switching to IgE production,” Lafaille says. She also predicts that allergists may be able to examine aspects of these memory cells to forecast whether a patient's allergy is likely to last or disappear with time or treatment.

“Knowing which population of cells store allergies in long-term memory may eventually help scientists identify other ways to kill the allergy cells,” says Cecilia Berin, an immunologist at Northwestern University Feinberg School of Medicine. “You could potentially get rid of not only your peanut allergy but also all of your allergies.”

6 . Being bored is no fun, especially at work. However, a recent study from the Research School of Management at the Australian National University suggests that boredom may have an unexpected benefit.

In a study, 52 participants (参与者) were given a boring task of separating red from green beans for 30 minutes, while another group of 49 participants was asked to create art projects with paper, beans, and glue. Then both groups were instructed to spend five minutes on a creative task. Surprisingly, the group that had performed the boring task produced a higher quantity and quality of creative ideas than the group that had taken part in the art project.

“Boredom is not necessarily terrible based on my research,” says the study’s lead author, Guihyun Park. “People want to get out of a boring state, so they tend to find novelty, which can lead to unique thinking and bring out creativity.” Moreover, it’s also worth noting that studies have found that not everyone experiences the same level of creative benefits from boredom. Researchers have discovered in one experiment that participants who are open to new experiences and driven to achieve specific goals are more likely to see positive effects from being bored.

Finally, Park admits that not every type of job allows a state of boredom, and it really can be detrimental to some important work. “I would say at safety jobs where you need to stay alert (警惕的) all the time, like police or safety guards, boredom will keep your mind wandering, which is really bad,” says Park. “Also, those jobs require less creativity but much attention to details instead; boredom won’t help much there.”

But for designers and anyone in a creative field, boredom is not something to fear, but to embrace (欣然接受). J.K. Rowling, the author of the Harry Potter series, has shared how she would spend hours sitting on trains, letting her mind wander and coming up with new ideas for her stories. This boredom allowed her to tap into her creativity and imagination, leading to one of the most beloved book series ever.